INT37687

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Context Info
Confidence 0.29
First Reported 1987
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.61
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PLAUR) extracellular region (PLAUR) plasma membrane (PLAUR)
enzyme binding (PLAUR)
PLAUR (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 1 87.96 High High
metalloproteinase 128 83.56 Quite High
Angina 1 82.96 Quite High
cva 18 69.76 Quite High
Inflammation 5 56.48 Quite High
Spinal cord 4 42.80 Quite Low
Pain 7 41.08 Quite Low
Arthritis 42 10.92 Low Low
cytokine 13 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hematoma 4 99.50 Very High Very High Very High
Paroxysmal Nocturnal Hemoglobinuria 158 98.38 Very High Very High Very High
Thrombophilia 5 98.24 Very High Very High Very High
Metastasis 72 98.00 Very High Very High Very High
Prostate Cancer 174 95.36 Very High Very High Very High
Thromboembolism 1 93.36 High High
Myocardial Infarction 3 90.76 High High
Hemolysis 55 84.00 Quite High
Angina 1 82.96 Quite High
Cerebral Haemorrage 2 77.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hematoma was then evacuated with urokinase irrigation.
urokinase Binding (irrigation) of associated with hematoma
1) Confidence 0.29 Published 2005 Journal J Clin Neurosci Section Abstract Doc Link 16051093 Disease Relevance 0.43 Pain Relevance 0.09
Furthermore, the shape of the oscillatory waves could be modulated by suboptimal doses of kinase and phosphatase inhibitors, indicating that the dynamic uPAR-CR4 interactions are coupled with oscillatory signal transduction machinery.
uPAR Binding (interactions) of
2) Confidence 0.25 Published 2007 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC1904449 Disease Relevance 0.11 Pain Relevance 0.03
T-PA is thought to be more important in fibrinolysis, due to its fibrin binding capacity, whilst u-PA, especially when it is bound to its specific cell surface receptor (u-PAR), is thought to be involved in tissue remodelling and cell migration processes [7].
u-PAR Binding (bound) of
3) Confidence 0.25 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.36 Pain Relevance 0.37
T-PA is thought to be more important in fibrinolysis, due to its fibrin binding capacity, whilst u-PA, especially when it is bound to its specific cell surface receptor (u-PAR), is thought to be involved in tissue remodelling and cell migration processes [7].
surface receptor Binding (bound) of
4) Confidence 0.22 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.36 Pain Relevance 0.37
Clinical experience with urokinase in intracoronary thrombolysis.
urokinase Binding (experience) of
5) Confidence 0.21 Published 1987 Journal Clin Cardiol Section Title Doc Link 3581531 Disease Relevance 0.30 Pain Relevance 0.11
The receptor (u-PAR/CD87) focuses the enzymatic activity of u-PA and allows activation of plasminogen (PG) at the cell surface, which in turn, is bound to the cell membrane by ?
u-PAR Binding (receptor) of
6) Confidence 0.05 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 0.60 Pain Relevance 0.04
An additional mechanism of thrombophilia in PNH might be the impairment of the fibrinolytic system, due to the lack of membrane-bound urokinase-type plasminogen activator receptor (uPAR), which is GPI-linked, and to the excess of its soluble form (Ninomiya et al 1997; Sloand et al 2006).
uPAR Binding (bound) of associated with thrombophilia and paroxysmal nocturnal hemoglobinuria
7) Confidence 0.04 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721357 Disease Relevance 1.12 Pain Relevance 0.03
Several other molecules interact 'constitutively' with u-PAR domains 2 and/or 3, thereby functioning as 'coreceptors'.
u-PAR Binding (interact) of
8) Confidence 0.04 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 0.34 Pain Relevance 0

General Comments

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