INT3770

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Context Info
Confidence 0.43
First Reported 1977
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 3.55
Pain Relevance 12.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Nrm) nucleus (Nrm)
Anatomy Link Frequency
neurons 5
POAH 1
neuronal 1
tail 1
brain 1
Nrm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Raphe magnus 126 100.00 Very High Very High Very High
Pain 40 100.00 Very High Very High Very High
tail-flick 17 99.68 Very High Very High Very High
Opioid 36 99.52 Very High Very High Very High
lidocaine 13 99.44 Very High Very High Very High
Morphine 106 99.40 Very High Very High Very High
Hyperalgesia 7 98.64 Very High Very High Very High
tolerance 21 98.40 Very High Very High Very High
depression 3 98.16 Very High Very High Very High
Antinociceptive 3 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 34 100.00 Very High Very High Very High
Hyperalgesia 8 98.64 Very High Very High Very High
Nociception 14 98.40 Very High Very High Very High
Depression 3 98.16 Very High Very High Very High
Low Back Pain 4 96.48 Very High Very High Very High
Headache 5 95.40 Very High Very High Very High
Hypoalagesia 2 86.92 High High
Urological Neuroanatomy 4 80.52 Quite High
Shock 1 76.80 Quite High
Paralysis 1 73.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lidocaine microinjections into the NRM effectively blocked NRM stimulation-produced inhibition of the TF reflex (prelidocaine stimulation thresholds were increased two to three times), but did not affect stimulation-produced inhibition from the LC. 3.
Negative_regulation (inhibition) of NRM associated with raphe magnus, locus ceruleus, tail-flick and lidocaine
1) Confidence 0.43 Published 1987 Journal J. Neurophysiol. Section Abstract Doc Link 3612222 Disease Relevance 0.23 Pain Relevance 1.20
The decrement in antinociceptive effect and hyperalgesia produced by higher doses of R(+)-BAC may result from a presynaptic inhibition of excitatory inputs to the NRM and NGCp alpha, postsynaptic hyperpolarization of neurons in these nuclei or the unmasking of a descending facilitatory pathway originating from the NRM, NGCp alpha and NGC.
Negative_regulation (inhibition) of NRM in neurons associated with raphe magnus, hyperalgesia and antinociceptive
2) Confidence 0.43 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562560 Disease Relevance 0.25 Pain Relevance 0.77
Therefore, suppression of neural activity in the NRM should reduce thermoregulatory responses to peripheral thermal challenges, but not affect responses elicited by manipulation of POAH temperature.
Negative_regulation (suppression) of NRM in POAH associated with raphe magnus
3) Confidence 0.38 Published 1999 Journal Brain Res. Section Abstract Doc Link 10411995 Disease Relevance 0 Pain Relevance 0.50
Activity of neurons in the NRM was inhibited by these stimuli.
Negative_regulation (inhibited) of NRM in neurons associated with raphe magnus
4) Confidence 0.37 Published 2008 Journal Cephalalgia Section Abstract Doc Link 18454788 Disease Relevance 0.62 Pain Relevance 0.89
In these animals, morphine suppressed the neuronal nociceptive activity to the same extent as seen with morphine alone and did not affect the NRM inhibition.
Negative_regulation (inhibition) of NRM in neuronal associated with nociception, raphe magnus and morphine
5) Confidence 0.37 Published 1987 Journal Gen. Pharmacol. Section Abstract Doc Link 3032736 Disease Relevance 0.18 Pain Relevance 1.25
These data also suggest that the hyperalgesia produced by high doses of baclofen does not result from disinhibition of a serotonergic pain facilitatory pathway, but rather from direct inhibition of tonically-active pain inhibitory neurons in the NRM and NGCpalpha.
Negative_regulation (inhibition) of NRM in neurons associated with raphe magnus, pain and hyperalgesia
6) Confidence 0.37 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9572593 Disease Relevance 0.49 Pain Relevance 1.01
The results do not support the hypothesis that NRM stimulation-produced inhibition is mediated by 5-HT release.
Negative_regulation (inhibition) of NRM associated with raphe magnus
7) Confidence 0.37 Published 1988 Journal Gen. Pharmacol. Section Abstract Doc Link 3258264 Disease Relevance 0 Pain Relevance 0.60
The relative phasic activity of on-cell and off-cell in NRM was decreased or lost when TF was inhibited by brain stimulation and morphine analgesia.
Negative_regulation (decreased) of NRM in brain associated with raphe magnus, analgesia and morphine
8) Confidence 0.34 Published 1990 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 2125873 Disease Relevance 0.08 Pain Relevance 0.75
The neural block of the NRM or NRPG with lidocaine also did not change significantly the latency for the tail flick reflex.
Negative_regulation (block) of NRM in tail associated with raphe magnus, tail-flick and lidocaine
9) Confidence 0.34 Published 1999 Journal Brain Res. Section Abstract Doc Link 10320704 Disease Relevance 0.30 Pain Relevance 0.99
NRM induced inhibition is probably mediated by a direct projection via the dorsolateral funiculus to spinal dorsal horn laminae I, II, V and VI.
Negative_regulation (inhibition) of NRM in dorsal horn associated with raphe magnus and spinal dorsal horn
10) Confidence 0.34 Published 1977 Journal Brain Res. Section Abstract Doc Link 861731 Disease Relevance 0 Pain Relevance 0.54
More specifically, NA projections to NRM neurons appear to be inhibitory since iontophoretically applied norepinephrine (NE) inhibits the activity of NRM neurons.
Negative_regulation (inhibits) of NRM in neurons associated with raphe magnus
11) Confidence 0.33 Published 1985 Journal Brain Res. Section Abstract Doc Link 2859092 Disease Relevance 0.40 Pain Relevance 1.01
Thus, the NA input to the NRM appears to increase pain sensitivity by tonically inhibiting NRM neurons.
Negative_regulation (inhibiting) of NRM in neurons associated with pain and raphe magnus
12) Confidence 0.29 Published 1985 Journal Brain Res. Section Abstract Doc Link 2859092 Disease Relevance 0.46 Pain Relevance 1.17
Extensive evidence has shown that some NRM cells inhibited by ?
Negative_regulation (inhibited) of NRM associated with raphe magnus
13) Confidence 0.25 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074357 Disease Relevance 0.55 Pain Relevance 2.15

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