INT37715

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Context Info
Confidence 0.48
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 34
Total Number 34
Disease Relevance 10.52
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MSC) DNA binding (MSC)
Anatomy Link Frequency
chondrocytes 2
hepatocytes 2
bone marrow 2
stem cell 2
smooth muscle 1
MSC (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 73 99.12 Very High Very High Very High
Morphine 5 98.74 Very High Very High Very High
cytokine 52 98.48 Very High Very High Very High
Inflammation 79 98.08 Very High Very High Very High
Arthritis 35 96.48 Very High Very High Very High
Osteoarthritis 39 96.32 Very High Very High Very High
Fibrositis 3 96.04 Very High Very High Very High
Dopamine 4 96.00 Very High Very High Very High
Neurotransmitter 12 94.36 High High
fibrosis 41 91.52 High High
Disease Link Frequency Relevance Heat
Adhesions 61 99.96 Very High Very High Very High
Muscle Disease 1 99.92 Very High Very High Very High
Injury 101 99.76 Very High Very High Very High
Myocardial Infarction 83 99.72 Very High Very High Very High
Obesity 168 99.64 Very High Very High Very High
Graft Vs Host Disease 22 99.20 Very High Very High Very High
Arthralgia 26 99.12 Very High Very High Very High
Malignant Neoplastic Disease 1 98.24 Very High Very High Very High
INFLAMMATION 96 98.08 Very High Very High Very High
Autoimmune Disease 9 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The T1/2 elimination of the two morphine preparations was similar, demonstrating insignificant risk of MSC accumulation.
Positive_regulation (accumulation) of MSC associated with morphine
1) Confidence 0.48 Published 1987 Journal J. Clin. Oncol. Section Abstract Doc Link 3585450 Disease Relevance 0.25 Pain Relevance 0.60
MSC are an increasing health concern in France, growing in importance on the public health agenda.
Positive_regulation (increasing) of MSC
2) Confidence 0.43 Published 2003 Journal J Rheumatol Suppl Section Abstract Doc Link 12926653 Disease Relevance 0.32 Pain Relevance 0.12
Several methods could be used to increase MSC population and its osteogenic differentiation in the pathological area:
Positive_regulation (increase) of MSC
3) Confidence 0.37 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2964482 Disease Relevance 0.54 Pain Relevance 0
This increased prevalence of MSC in women, is a pattern recognised in many chronic musculoskeletal conditions including RA, OA and fibromyalgia[19,23].
Positive_regulation (increased) of MSC associated with fibrositis, osteoarthritis and arthritis
4) Confidence 0.36 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2830178 Disease Relevance 1.02 Pain Relevance 0.57
It is recognised that MSC increase in prevalence and severity with age[20].
Positive_regulation (increase) of MSC
5) Confidence 0.36 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2830178 Disease Relevance 0.50 Pain Relevance 0.29
It is notable that the average age of the clinic attendees was 8.5 years older than the background population and it may be that an increase in MSC could be expected in an older population.
Positive_regulation (increase) of MSC
6) Confidence 0.36 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2830178 Disease Relevance 0.45 Pain Relevance 0.07
After the cultivation of MSC from the mononuclear cell fraction (passage 0) and at the end of each individual passage, the MSC were analyzed by flow cytometry to monitor the surface marker profile during their ex vivo expansion.
Positive_regulation (cultivation) of MSC in mononuclear cell
7) Confidence 0.30 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.10 Pain Relevance 0
Large-scale gene expression profiling of MSC during ex vivo expansion
Positive_regulation (profiling) of MSC
8) Confidence 0.30 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.06 Pain Relevance 0
Large-scale gene expression profiling of MSC during osteogenesis
Positive_regulation (profiling) of MSC
9) Confidence 0.30 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.05 Pain Relevance 0
For the induction of osteogenesis MSC were seeded at a density of 104 cells/cm2 in expansion medium.
Positive_regulation (induction) of MSC
10) Confidence 0.27 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.10 Pain Relevance 0.08
This observation could be confirmed by the comparison of the morphology of the two cell types: Human osteoblasts isolated from hipbone represented non-mineralized osteoblasts with fibroblast-like phenotype, morphologically similar to induced MSC on day seven after induction.


Positive_regulation (induced) of MSC in fibroblast
11) Confidence 0.27 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.07 Pain Relevance 0
Human MSC from three different donors (Nr. 9–11) were cultured until their fourth passage and were induced to osteogenic differentiation at a confluence of 70–80%.
Positive_regulation (induced) of MSC
12) Confidence 0.27 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.35 Pain Relevance 0.07
Using similar neurogenic medium (NPMM or Neurobasal), MSC expressed dopaminergic specific genes (En1, En2, LMx1a, Wnt1, Ptx3, and Nuur1 and were positive to GFAP, MAP-2 and NSE but continued to express the neural stem cell marker nestin.
Positive_regulation (positive) of MSC in stem cell
13) Confidence 0.24 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.08 Pain Relevance 0.24
BM-MSC were differentiated in neuron-like cells under specific induction (NPBM + cAMP + IBMX + NGF + Insulin).
Positive_regulation (induction) of BM-MSC in neuron
14) Confidence 0.24 Published 2008 Journal BMC Genomics Section Abstract Doc Link PMC2358905 Disease Relevance 0.16 Pain Relevance 0.04
In our experiments, induction of hepatocyte-specific genes in MSC failed by using previously reported culture conditions [14], [8], [22].
Positive_regulation (induction) of MSC in hepatocyte
15) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.39 Pain Relevance 0
Engrafted MSC in liver express alpha smooth muscle actin and their localization merges with collagen deposition
Positive_regulation (Engrafted) of MSC in smooth muscle
16) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.09 Pain Relevance 0.05
Adult MSC and pMSC could be differentiated into adipocytes as shown by oil-red-O staining of lipid droplets (Fig. 1C), into chondrocytes as shown by Masson's trichrome and immunohistochemistry for collagen type II (Fig. 1D) and into osteoblasts expressing alkaline phosphatase activity (Fig. 1E).
Positive_regulation (Adult) of MSC in chondrocytes associated with obesity
17) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.20 Pain Relevance 0
Adipogenic, chondrogenic and osteogenic differentiation of adult and pediatric MSC
Positive_regulation (pediatric) of MSC
18) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.20 Pain Relevance 0
However, the fact that we did not detect albumin at protein levels suggest that there might only be a small population of MSC differentiating towards hepatocytes.
Positive_regulation (population) of MSC in hepatocytes
19) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.13 Pain Relevance 0
Contamination of underlying MSC with Huh-7 cells from the upper compartment (transwell) was excluded by performing experiments in an inverted cell-setting.
Positive_regulation (underlying) of MSC in upper
20) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.27 Pain Relevance 0

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