INT37722

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Context Info
Confidence 0.75
First Reported 1987
Last Reported 2011
Negated 15
Speculated 1
Reported most in Body
Documents 103
Total Number 104
Disease Relevance 81.57
Pain Relevance 14.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (NCAM1) cell adhesion (NCAM1) plasma membrane (NCAM1)
Anatomy Link Frequency
neural 14
NK cells 10
T cells 10
lymphocytes 3
leukocytes 3
NCAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 7 100.00 Very High Very High Very High
Enkephalin 7 100.00 Very High Very High Very High
Neuropeptide 6 100.00 Very High Very High Very High
substance P 6 100.00 Very High Very High Very High
medulla 157 99.98 Very High Very High Very High
chemokine 65 99.80 Very High Very High Very High
Spinal cord 24 99.72 Very High Very High Very High
Serotonin 19 99.68 Very High Very High Very High
Hippocampus 92 99.64 Very High Very High Very High
Raphe 60 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 117 100.00 Very High Very High Very High
Pancreatic Cancer 32 99.84 Very High Very High Very High
Cancer 1203 99.76 Very High Very High Very High
Lymphatic System Cancer 77 99.72 Very High Very High Very High
Chondrosarcoma 8 99.56 Very High Very High Very High
Infection 534 99.44 Very High Very High Very High
Enteropathy 2 99.30 Very High Very High Very High
Hepatitis C Virus Infection 820 99.10 Very High Very High Very High
Endometriosis 452 99.00 Very High Very High Very High
Rheumatoid Arthritis 110 98.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expressions of CD3(+), CD3(+)CD4(+), CD3(+)CD8(+), CD3(-)CD16(+)CD56(+), and CD3(+)CD25(+) were measured as percentages of total lymphocytes by flow cytometer at 5 time points.
Gene_expression (Expressions) of CD56 in lymphocytes
1) Confidence 0.75 Published 2006 Journal Clin. Chim. Acta Section Body Doc Link 16487501 Disease Relevance 0.08 Pain Relevance 0
Both cellular components expressed non-polysialylated neural cell adhesion molecule (NCAM)-L species, and several overlapping areas of synaptophysin and GFAP immunoreactivity were present.
Gene_expression (expressed) of NCAM in neural associated with adhesions
2) Confidence 0.74 Published 2006 Journal Pathol. Res. Pract. Section Abstract Doc Link 16413693 Disease Relevance 1.22 Pain Relevance 0.11
Immunocytochemical techniques was used to compare the proportion of neurons expressing various neurotransmitters (tyrosine hydroxylase, choline acetyltransferase and gamma-aminobutyric acid), neuropeptides (Leu-enkephalin and substance P) and neural cell adhesion molecules (NCAM) in the hippocampus, frontal (area 10) and occipital (area 17) cortices of neurologically normal elderly humans to that of age-matched Alzheimer disease (AD) patients.
Gene_expression (expressing) of NCAM in neural associated with neurotransmitter, alzheimer's dementia, neuropeptide, hippocampus, enkephalin, adhesions and substance p
3) Confidence 0.73 Published 1999 Journal Exp. Gerontol. Section Abstract Doc Link 10197733 Disease Relevance 0.58 Pain Relevance 0.38
The diagnosis of peripheral T-cell lymphoma, unspecified (WHO classification) with CD56 expression, was established based on the results of lymph node biopsy and pleural effusion cytology.
Gene_expression (expression) of CD56 in unspecified associated with pleural effusion and lymphatic system cancer
4) Confidence 0.72 Published 2006 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 17233392 Disease Relevance 0.83 Pain Relevance 0.20
It has been shown that the rat raphe serotonin neurons do not express PSA-NCAM [56].
Neg (not) Gene_expression (express) of PSA-NCAM in serotonin neurons associated with serotonin and raphe
5) Confidence 0.71 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2612005 Disease Relevance 0.17 Pain Relevance 0.28
In the rat solitary tract nucleus, the overall PSA-NCAM expression decreases during the first two postnatal weeks and persists only at synapses in the adult [40].
Gene_expression (expression) of PSA-NCAM in solitary tract nucleus
6) Confidence 0.71 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2612005 Disease Relevance 0.34 Pain Relevance 0.21
The highest expression of PSA-NCAM occurs in the developing nervous system, where it is generally considered a promoter of neural plasticity, allowing migration of neural and nonneural precursors and facilitating axonal pathfinding and synaptogenesis [4,5].
Gene_expression (expression) of PSA-NCAM in neural
7) Confidence 0.71 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2612005 Disease Relevance 0.19 Pain Relevance 0.03
The localization of PSA-NCAM to the caudal part of the trigeminal spinal sensory nucleus and its changes with age are consistent with data on the rat dorsal horn spinal cord showing that PSA-NCAM is more widely expressed during embryonic and early postnatal than in adult life, when it is confined to the superficial laminae [42,43].
Gene_expression (expressed) of PSA-NCAM in caudal part associated with dorsal horn and spinal cord
8) Confidence 0.71 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2612005 Disease Relevance 0.27 Pain Relevance 0.25
Furthermore, PSA-NCAM expression has been shown to be dynamically controlled by the electrical stimulation of the vagal afferents [40] and, conversely, a repetitive stimulation of afferent fibres leads to phasic and long-term plasticity in adult animals [55].
Gene_expression (expression) of PSA-NCAM
9) Confidence 0.71 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2612005 Disease Relevance 0.31 Pain Relevance 0.25
Immunohistochemically, the tumor cells were positive for synaptophysin, chromogranin A, and CD56.
Gene_expression (positive) of CD56 associated with cancer
10) Confidence 0.68 Published 2009 Journal J Chin Med Assoc Section Abstract Doc Link 19948438 Disease Relevance 1.20 Pain Relevance 0.07
production (IL-12 and IL-18) of CD56brightCD16- NK [36], therefore a possible mechanism limiting the production of these cytokines and may adversely alter the role of CD56brightCD16- NK during pathogen invasion and lysis.
Gene_expression (production) of CD56 associated with cytokine
11) Confidence 0.65 Published 2010 Journal J Transl Med Section Body Doc Link PMC2829521 Disease Relevance 0.91 Pain Relevance 0.26
-CD56/CD68 double immunohistochemistry sections were blocked in normal goat serum (NGS, one part serum, four parts PBS plus 5% BSA) and subsequently incubated overnight with a polyclonal anti-IL11R?
Gene_expression (/) of CD56
12) Confidence 0.65 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
CD56bright NK cells have the ability to produce high levels of immunoregulatory cytokines, in particular interferon (IFN)-?
Gene_expression (have) of CD56 in NK cells associated with cytokine
13) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.42 Pain Relevance 0.23
CD56brightCD16- NK preferentially expresses the chemokine receptor 7 (CCR7) and higher levels of chemokine receptor (CXCR) 3 in response to chemokines CCL19, CCL21 and CXCL10, CXCL11 respectively [27,28].
Gene_expression (expresses) of CD56 associated with chemokine
14) Confidence 0.65 Published 2010 Journal J Transl Med Section Body Doc Link PMC2829521 Disease Relevance 0.86 Pain Relevance 0.29
Both cellular components expressed non-polysialylated neural cell adhesion molecule (NCAM)-L species, and several overlapping areas of synaptophysin and GFAP immunoreactivity were present.
Gene_expression (expressed) of neural cell adhesion molecule in neural associated with adhesions
15) Confidence 0.65 Published 2006 Journal Pathol. Res. Pract. Section Abstract Doc Link 16413693 Disease Relevance 1.21 Pain Relevance 0.11
At all ages examined, PSA-NCAM is restricted to the spinal trigeminal nucleus (Figures 5, 6, 7A), where it is represented by neuronal cell bodies and processes, and is virtually absent in the principal and mesencephalic nuclei.
Neg (absent) Gene_expression (restricted) of PSA-NCAM in spinal trigeminal nucleus
16) Confidence 0.62 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2612005 Disease Relevance 0 Pain Relevance 0.16
At all ages examined, PSA-NCAM is restricted to the spinal trigeminal nucleus (Figures 5, 6, 7A), where it is represented by neuronal cell bodies and processes, and is virtually absent in the principal and mesencephalic nuclei.
Neg (absent) Gene_expression (absent) of PSA-NCAM in spinal trigeminal nucleus
17) Confidence 0.62 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2612005 Disease Relevance 0 Pain Relevance 0.21
They share several common features, such as the expression of high levels of MHC class II molecules (HLA-DR) and lack of lineage specific markers (CD3, CD14, CD16, CD19, CD20, and CD56) [13].
Gene_expression (expression) of CD56
18) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 0.59 Pain Relevance 0
Only within the part of SCC, were neuroendocrine (NE) markers (chromogranin A [CgA], NCAM, and synaptophysin [SNP]) expressed.
Gene_expression (expressed) of NCAM associated with carcinoma
19) Confidence 0.58 Published 2007 Journal Hinyokika Kiyo Section Abstract Doc Link 17702184 Disease Relevance 1.46 Pain Relevance 0.08
Immunohistochemically, the neuroendocrine areas were reactive for C-kit, epithelial membrane antigen, cytokeratin, cytokeratin 7, chromogranin A, neuron-specific enolase, CD56 and S-100 protein.
Gene_expression (reactive) of CD56 in neuron
20) Confidence 0.57 Published 2008 Journal APMIS Section Abstract Doc Link 19024610 Disease Relevance 1.17 Pain Relevance 0.08

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