INT37734

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Context Info
Confidence 0.46
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 9.17
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ang) extracellular space (Ang) extracellular region (Ang)
RNA binding (Ang) nucleus (Ang) nuclease activity (Ang)
Anatomy Link Frequency
kidney 2
myocytes 1
CSF 1
band 1
amniotic fluid 1
Ang (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 30 100.00 Very High Very High Very High
lidocaine 2 98.76 Very High Very High Very High
Catecholamine 5 98.24 Very High Very High Very High
antagonist 39 97.44 Very High Very High Very High
cva 7 97.40 Very High Very High Very High
chemokine 12 95.68 Very High Very High Very High
local anesthetic 1 94.80 High High
metalloproteinase 24 93.48 High High
Inflammation 96 92.24 High High
anesthesia 7 92.20 High High
Disease Link Frequency Relevance Heat
Renal Disease 116 99.92 Very High Very High Very High
Pancreatic Cancer 7 99.84 Very High Very High Very High
Volume Depletion And Dehydration 1 99.26 Very High Very High Very High
Apoptosis 51 99.16 Very High Very High Very High
Cancer 90 99.08 Very High Very High Very High
Premature Birth 40 98.40 Very High Very High Very High
Hemorrhage 5 97.40 Very High Very High Very High
Rupture 6 96.92 Very High Very High Very High
Lymphatic System Cancer 62 96.88 Very High Very High Very High
Diabetes Mellitus 115 95.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this case the increase in Ang II may compete with the ARB for the AT1 receptor [47].
Positive_regulation (increase) of Ang
1) Confidence 0.46 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.66 Pain Relevance 0
Our data implicates that the proinflammatory properties of Ang-(1–7) and the Mas receptor in the kidney are primarily stimulated by a local activation of the NF-?
Positive_regulation (stimulated) of Ang in kidney
2) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672164 Disease Relevance 0.60 Pain Relevance 0.40
Strong protein band expression was obtained in the protein lysates of pancreatic cancer surrounding tissue, and mean serum ANG concentration was increased in pancreatic cancer patients.
Positive_regulation (increased) of ANG in band associated with pancreatic cancer
3) Confidence 0.39 Published 1999 Journal Pancreas Section Abstract Doc Link 10206479 Disease Relevance 1.30 Pain Relevance 0.75
The activation of the renal renin angiotensin system (RAS), characterized by elevated ACE expression and increased local angiotensin (Ang) II production, has been found in many human kidney diseases [3].
Positive_regulation (increased) of Ang in kidney associated with renal disease
4) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672164 Disease Relevance 0.88 Pain Relevance 0.17
The microinjection of ANG II itself into sites in which lidocaine blocked ANG II pressor responses had no effect on arterial pressure but did produce drinking.
Positive_regulation (microinjection) of ANG associated with lidocaine
5) Confidence 0.39 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 3591987 Disease Relevance 0 Pain Relevance 0.29
TRPC6 up-regulation in Ang II-induced podocyte apoptosis might result from ERK activation and NF-kappaB translocation.
Positive_regulation (up-regulation) of Ang in podocyte associated with apoptosis
6) Confidence 0.32 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Title Doc Link 19546355 Disease Relevance 0.64 Pain Relevance 0.13
Pretreatment with ANP fully inhibited Ang II-stimulation of L-type Ca2+ channel activity (Fig. 2b) and had no effect on ISO-stimulation of L-type Ca2+ channel activity (Fig. 2d).Fig. 2L-type Ca2+ channel activity was analyzed in ventricular myocytes by whole-cell patch-clamp recordings.
Positive_regulation (stimulation) of Ang in myocytes
7) Confidence 0.31 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0 Pain Relevance 0
Although more research is needed, activation of the (pro)renin receptor may contribute to the pathology of renal disease by increasing local Ang II formation and by increasing the expression of profibrotic mediators.
Positive_regulation (increasing) of Ang associated with renal disease
8) Confidence 0.31 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.84 Pain Relevance 0.07
Thus, aliskiren may contribute to end organ protection by reducing the deleterious actions of Ang II and the Ang II-independent effects of (pro)renin receptor activation.
Positive_regulation (activation) of Ang
9) Confidence 0.31 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.59 Pain Relevance 0.04
Thus, aliskiren may contribute to end organ protection by reducing the deleterious actions of Ang II and the Ang II-independent effects of (pro)renin receptor activation.
Positive_regulation (activation) of Ang
10) Confidence 0.31 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.59 Pain Relevance 0.04
In conscious dogs 24 h of dehydration with sodium-rich food significantly increased ANG II concentration in the plasma (to 59.8 +/- 16.5 pg X ml-1) and CSF (to 71.8 +/- 20.1 pg X ml-1).
Positive_regulation (increased) of ANG in CSF associated with volume depletion and dehydration
11) Confidence 0.25 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 3706577 Disease Relevance 0.10 Pain Relevance 0.09
ANG II activation of the AT1R is associated with VEGF secretion and tumour angiogenesis is suppressed following AT1R blockade [23,29].
Positive_regulation (activation) of ANG associated with cancer
12) Confidence 0.22 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 1.29 Pain Relevance 0.08
Angiotensin II (ANG II) is required for unimpaired adrenal reflex secretion of catecholamines after hemorrhage in the dog.
Positive_regulation (required) of ANG associated with catecholamine and cva
13) Confidence 0.10 Published 1985 Journal Am. J. Physiol. Section Abstract Doc Link 3976910 Disease Relevance 0.16 Pain Relevance 0.32
An increase in midtrimester concentrations of amniotic fluid MMP-8, IL-6, and angiogenin are risk factors for early spontaneous preterm delivery (<32 weeks).
Positive_regulation (increase) of angiogenin in amniotic fluid associated with premature birth
14) Confidence 0.09 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.59 Pain Relevance 0.16
Pretreatment with prostaglandin E(2) (10(-5) M) resulted in a threefold increase in the ANG II-evoked response.
Positive_regulation (increase) of ANG
15) Confidence 0.06 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10762617 Disease Relevance 0 Pain Relevance 0.23
Of interest, the ability of MSC cultures of secreting high levels of angiogenic cytokines, such as VEGF, IL-8, angiogenin and CCL2, was significantly (p<0.01) enhanced by the concomitant presence of lymphoma cells.
Positive_regulation (levels) of angiogenin associated with lymphatic system cancer and cytokine
16) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 0.86 Pain Relevance 0.09
CONCLUSIONS: In patients with UA, cardiac RAS is activated, resulting in increased Ang II formation.
Positive_regulation (increased) of Ang
17) Confidence 0.03 Published 2001 Journal J. Am. Coll. Cardiol. Section Body Doc Link 11451295 Disease Relevance 0 Pain Relevance 0
RESULTS: Cardiac Ang II generation was higher in patients with UA than it was in patients with SA or in controls (p < 0.001) due to increased de novo cardiac Ang I formation and its enhanced fractional conversion rate to Ang II.
Positive_regulation (increased) of Ang
18) Confidence 0.03 Published 2001 Journal J. Am. Coll. Cardiol. Section Body Doc Link 11451295 Disease Relevance 0.07 Pain Relevance 0

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