INT37745

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Context Info
Confidence 0.60
First Reported 1983
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 22
Total Number 24
Disease Relevance 5.15
Pain Relevance 6.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Sdcbp) cytoplasm (Sdcbp)
Anatomy Link Frequency
liver 4
muscle 4
spinal cord 4
kidney 2
nerve 2
Sdcbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 16 99.98 Very High Very High Very High
cerebral cortex 12 99.84 Very High Very High Very High
Codeine 12 99.78 Very High Very High Very High
cocaine 9 99.72 Very High Very High Very High
Hippocampus 12 99.16 Very High Very High Very High
Morphine 12 99.10 Very High Very High Very High
Spinal cord 13 98.64 Very High Very High Very High
ischemia 35 98.40 Very High Very High Very High
Sciatic nerve 7 96.28 Very High Very High Very High
Action potential 2 94.84 High High
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 3 98.84 Very High Very High Very High
Wound Healing 21 97.76 Very High Very High Very High
Pleurisy 39 96.08 Very High Very High Very High
Cv Unclassified Under Development 35 95.24 Very High Very High Very High
Stress 63 94.72 High High
Injury 101 93.56 High High
Adult Respiratory Distress Syndrome 7 93.28 High High
Renal Failure 1 92.04 High High
Pressure And Volume Under Development 14 91.92 High High
Lung Injury 2 89.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The apparent antioxidative nature of morphine sulfate was also observed in its effects on induced and noninduced MDA production, both cocaine hydrochloride and codeine phosphate stimulated MDA production by about 20% in the absence of any inducers.
Positive_regulation (induced) of Gene_expression (production) of MDA associated with codeine, cocaine and morphine
1) Confidence 0.60 Published 1987 Journal Biochem. Med. Metab. Biol. Section Abstract Doc Link 3593597 Disease Relevance 0 Pain Relevance 0.71
The apparent antioxidative nature of morphine sulfate was also observed in its effects on induced and noninduced MDA production, both cocaine hydrochloride and codeine phosphate stimulated MDA production by about 20% in the absence of any inducers.
Positive_regulation (stimulated) of Gene_expression (production) of MDA associated with codeine, cocaine and morphine
2) Confidence 0.60 Published 1987 Journal Biochem. Med. Metab. Biol. Section Abstract Doc Link 3593597 Disease Relevance 0 Pain Relevance 0.70
The apparent antioxidative nature of morphine sulfate was also observed in its effects on induced and noninduced MDA production, both cocaine hydrochloride and codeine phosphate stimulated MDA production by about 20% in the absence of any inducers.
Positive_regulation (noninduced) of Gene_expression (production) of MDA associated with codeine, cocaine and morphine
3) Confidence 0.43 Published 1987 Journal Biochem. Med. Metab. Biol. Section Abstract Doc Link 3593597 Disease Relevance 0 Pain Relevance 0.71
Neither single HBO(2) therapy nor five sequential daily treatments enhanced MDA production in lung tissue or serum.
Neg (Neither) Positive_regulation (enhanced) of Gene_expression (production) of MDA in lung
4) Confidence 0.12 Published 2004 Journal Shock Section Abstract Doc Link 15179139 Disease Relevance 0.38 Pain Relevance 0.06
The results showed that MDA levels increased significantly (P < 0.05) in nerve tissues, while GSH levels markedly decreased (P < 0.05) in a time-dependent manner.
Positive_regulation (increased) of Gene_expression (levels) of MDA in nerve
5) Confidence 0.12 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18470611 Disease Relevance 0.09 Pain Relevance 0.45
However, the levels of MDA, AST and ALT were obviously increased by ?
Positive_regulation (increased) of Gene_expression (levels) of MDA
6) Confidence 0.09 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994374 Disease Relevance 0 Pain Relevance 0
However, the levels of MDA, AST and ALT were significantly increased by ?
Positive_regulation (increased) of Gene_expression (levels) of MDA
7) Confidence 0.09 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994374 Disease Relevance 0 Pain Relevance 0
Ozkan et al. (2009) detected severe increases in the tissue levels of MDA and NO in rats subjected to intestinal ischemia (60 min) and subsequent reperfusion (60 min) [25].
Positive_regulation (increases) of Gene_expression (levels) of MDA associated with cv general 4 under development and ischemia
8) Confidence 0.07 Published 2010 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2913934 Disease Relevance 0.44 Pain Relevance 0.17
CS(2) exposure was found to markedly increase ROS and MDA levels in cerebral cortex, hippocampus, spinal cord and serum of rats in both time and symptom-dependent manners.
Positive_regulation (increase) of Gene_expression (levels) of MDA in spinal cord associated with hippocampus, cerebral cortex and spinal cord
9) Confidence 0.07 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19070609 Disease Relevance 0.21 Pain Relevance 0.41
The level of MDA was obviously increased by ?
Positive_regulation (increased) of Gene_expression (level) of MDA
10) Confidence 0.07 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994374 Disease Relevance 0.12 Pain Relevance 0.03
Also, the renal tissue from the cisplatin-treated rats showed significant decreases in the kidney glutathione (GSH) content and superoxide dismustase (SOD) activity and a significant increase in malondialdehyde (MDA) production in comparison to the values at 0 h (p < 0.05).
Positive_regulation (increase) of Gene_expression (production) of MDA in kidney
11) Confidence 0.06 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16141530 Disease Relevance 0.45 Pain Relevance 0.55
Irradiation of rats significantly increased intestinal epithelial damage, MPO activity, and MDA levels in comparison to the control group in a time-dependent fashion.
Positive_regulation (increased) of Gene_expression (levels) of MDA
12) Confidence 0.06 Published 2006 Journal J. Surg. Res. Section Body Doc Link 16780881 Disease Relevance 0.05 Pain Relevance 0
The significant alteration in the antioxidant profile accompanied by the elevated levels of MDA, a marker of free radical damage, may be attributed to impaired wound healing in immunocompromised rats (31).
Positive_regulation (elevated) of Gene_expression (levels) of MDA associated with wound healing
13) Confidence 0.05 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2249741 Disease Relevance 0.61 Pain Relevance 0
On the other hand, the aspecific stimulation of the cytochrome P-450-mediated paracetamol activation due to acetone addition further increases GSH depletion as well as MDA production.
Positive_regulation (increases) of Gene_expression (production) of MDA associated with paracetamol
14) Confidence 0.05 Published 1983 Journal Chem. Biol. Interact. Section Abstract Doc Link 6652811 Disease Relevance 0 Pain Relevance 0.49
We found that MDA levels in Cg-injected animals were increased by NOS inhibitors.
Positive_regulation (increased) of Gene_expression (levels) of MDA
15) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2879545 Disease Relevance 0.78 Pain Relevance 0.07
Acute estradiol injection caused a significant increase in both MDA levels and GPx activity in liver tissue when compared to the controls, (p <0.05 and p <0.02; respectively).
Positive_regulation (increase) of Gene_expression (levels) of MDA in liver
16) Confidence 0.04 Published 1999 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 10954129 Disease Relevance 0 Pain Relevance 0.09
The MDA levels in the Cg (P < .01), Cg + AE-ITU (P < .01) and Cg + L-NNA groups (P < .01) were significantly increased as compared to the control group (Figure 6).
Positive_regulation (increased) of Gene_expression (levels) of MDA
17) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2879545 Disease Relevance 0.30 Pain Relevance 0.12
Acetaminophen produced striking elevations of serum ALT, high MDA levels and a profound decrease in the liver iNOS.
Positive_regulation (elevations) of Gene_expression (produced) of MDA in liver associated with paracetamol
18) Confidence 0.04 Published 2003 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 15686124 Disease Relevance 0.34 Pain Relevance 0.51
However, in TA muscle, the HCE was effective in reducing lipid peroxidation only 48 h after acute exercise; the levels of MDA were still elevated 6 h after acute exercise (Fig. 3C).
Positive_regulation (elevated) of Gene_expression (levels) of MDA in muscle
19) Confidence 0.04 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC1192789 Disease Relevance 0.05 Pain Relevance 0
MDA levels in the Cg + AE-ITU and Cg + L-NNA groups were increased as compared to that of the Cg group (both P < .01).
Positive_regulation (increased) of Gene_expression (levels) of MDA
20) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2879545 Disease Relevance 0.28 Pain Relevance 0.11

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