INT37747

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Context Info
Confidence 0.69
First Reported 1987
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.91
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Gusb) endoplasmic reticulum (Gusb) carbohydrate metabolic process (Gusb)
lysosome (Gusb)
Anatomy Link Frequency
mast cells 1
Gusb (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 3 98.12 Very High Very High Very High
Inflammation 46 97.72 Very High Very High Very High
substance P 3 97.52 Very High Very High Very High
Serotonin 1 92.44 High High
cINOD 2 89.12 High High
rheumatoid arthritis 3 87.00 High High
Neuritis 1 78.40 Quite High
qutenza 1 70.64 Quite High
Inflammatory stimuli 1 40.04 Quite Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 50 97.72 Very High Very High Very High
Osteoarthritis 1 94.72 High High
Pressure And Volume Under Development 7 93.96 High High
Rheumatoid Arthritis 3 87.00 High High
Sprains And Strains 2 87.00 High High
Arthritis 2 82.48 Quite High
Laryngitis 1 79.04 Quite High
Neuritis 1 78.40 Quite High
Constipation 1 78.00 Quite High
Fever 1 77.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Detection of the neomycin phosphotransferase gene, the presence of high levels of beta-glucuronidase (GUS) transcripts and enzyme activity, and the histochemical localization of GUS confirmed the genetic transformation of S. buergeriana.
Localization (localization) of GUS
1) Confidence 0.69 Published 2003 Journal Plant Cell Rep. Section Abstract Doc Link 12910369 Disease Relevance 0.40 Pain Relevance 0.08
Two other transcripts were found downstream of COMP1: Gus (beta-glucoronidase) and elp3.
Localization (found) of Gus
2) Confidence 0.59 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.36 Pain Relevance 0.08
In isolated rat peritoneal mast cell preparations, norathyriol produced a dose-dependent inhibition of histamine and beta-glucuronidase release from mast cells challenged by compound 48/80, bradykinin and substance P.
Localization (release) of beta-glucuronidase in mast cells associated with bradykinin and substance p
3) Confidence 0.42 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7511107 Disease Relevance 0.64 Pain Relevance 0.43
Mean concentrations in both groups correlated strongly with the level of beta-glucuronidase activity as a measure of lysosomal enzyme release (r = 0.71, p less than 0.0001).
Localization (release) of beta-glucuronidase
4) Confidence 0.34 Published 1987 Journal Clin. Chim. Acta Section Abstract Doc Link 3594915 Disease Relevance 0.51 Pain Relevance 0.24

General Comments

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