INT37750

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Context Info
Confidence 0.74
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.72
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein binding, bridging (ANXA1) cilium (ANXA1) protein complex (ANXA1)
lipid metabolic process (ANXA1) cytoplasm (ANXA1) signal transduction (ANXA1)
ANXA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 1 99.68 Very High Very High Very High
Inflammation 124 96.88 Very High Very High Very High
aspirin 13 83.68 Quite High
cINOD 21 75.00 Quite High
agonist 8 66.16 Quite High
rheumatoid arthritis 12 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
acular 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 28 98.28 Very High Very High Very High
INFLAMMATION 139 96.88 Very High Very High Very High
Disease 8 67.28 Quite High
Apoptosis 20 5.00 Very Low Very Low Very Low
Cancer 12 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 12 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
Bacterial Respiratory Disease 8 5.00 Very Low Very Low Very Low
Adhesions 8 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of equal importance, CMV or ALX-transfected cell incubation with 10 µM peptide Ac2-26 (4 h) did not yield any expression/release of endogenous AnxA1 (as assessed by Western blotting in cell-free supernatants), Lipoxin A4 or SAA (assessed by ELISA) (data not shown).
Localization (expression) of AnxA1 associated with cytomegalovirus infection
1) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.34 Pain Relevance 0
There was also no detectable release of AnxA1 protein from either transfected cell line (as measured by ELISA, data not shown), suggesting that there was no interference by endogenous AnxA1 protein in the transfected HEK293 cells in the subsequent microarray experiments.


Localization (release) of AnxA1 protein
2) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.30 Pain Relevance 0.03
Relationship of AnxA1 and Ac2-26 to other compounds using a gene-expression based screening approach
Localization (Relationship) of AnxA1
3) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.07 Pain Relevance 0
Of equal importance, CMV or ALX-transfected cell incubation with 10 µM peptide Ac2-26 (4 h) did not yield any expression/release of endogenous AnxA1 (as assessed by Western blotting in cell-free supernatants), Lipoxin A4 or SAA (assessed by ELISA) (data not shown).
Localization (release) of AnxA1 associated with cytomegalovirus infection
4) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.34 Pain Relevance 0
In contrast, the corticosteroids facilitate the release of lipocortin which, through inhibition of phospholipase A2 reduces arachidonic acid release.
Localization (release) of lipocortin associated with corticosteroid
5) Confidence 0.02 Published 1987 Journal Drugs Section Abstract Doc Link 3595474 Disease Relevance 0.67 Pain Relevance 0.53

General Comments

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