INT37758

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Context Info
Confidence 0.75
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 7.09
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GC) extracellular space (GC) small molecule metabolic process (GC)
extracellular region (GC)
Anatomy Link Frequency
parenchymal cells 2
nipple 2
joint 1
cerebrospinal fluid 1
GC (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 6 99.38 Very High Very High Very High
Multiple sclerosis 72 96.80 Very High Very High Very High
imagery 5 95.56 Very High Very High Very High
Inflammation 46 92.44 High High
Inflammatory response 2 89.00 High High
Paracetamol 3 87.76 High High
Pain 1 85.60 High High
Inflammatory mediators 3 84.80 Quite High
Central nervous system 11 84.52 Quite High
rheumatoid arthritis 42 71.00 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 30 99.36 Very High Very High Very High
Cancer 215 98.68 Very High Very High Very High
Neuromyelitis Optica 162 96.96 Very High Very High Very High
Demyelinating Disease 79 96.80 Very High Very High Very High
Necrosis 7 96.00 Very High Very High Very High
INFLAMMATION 52 92.44 High High
Poisoning 1 90.64 High High
Neurodegenerative Disease 2 90.00 High High
Breast Cancer 20 89.68 High High
Disease 64 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clonidine administration decreased SBP, DBP and NE levels in PreMW, in PeriMW and in PeriMWE without any difference between the groups (F = 1.2, p = NS; F = 0.5, p = NS and F = 1.3, P = NS respectively).
Gene_expression (levels) of DBP associated with clonidine
1) Confidence 0.75 Published 1997 Journal J. Endocrinol. Invest. Section Abstract Doc Link 9438918 Disease Relevance 0.06 Pain Relevance 0.52
It is also called vitamin D-binding protein (DBP).
Gene_expression (called) of DBP
2) Confidence 0.65 Published 2008 Journal Postepy Hig Med Dosw (Online) Section Abstract Doc Link 19002085 Disease Relevance 0.51 Pain Relevance 0.14
Elevated urinary levels of vitamin D-binding protein in the inhabitants of a cadmium polluted area, Jinzu River basin, Japan.
Gene_expression (levels) of vitamin D-binding protein
3) Confidence 0.57 Published 2007 Journal Tohoku J. Exp. Med. Section Title Doc Link 17347552 Disease Relevance 0.61 Pain Relevance 0.09
CSF: cerebrospinal fluid; DBP: GC-globulin/Vitamin D-binding protein; EDSS: Expanded Disability Status Scale; GSN: gelsolin; MS: multiple sclerosis; MRI: Magnetic resonance imaging; QAlb: albumin CSF/serum quotient; SDS: sodium dodecyl sulfate.


Gene_expression (/) of GC-globulin in cerebrospinal fluid associated with multiple sclerosis and imagery
4) Confidence 0.48 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.96 Pain Relevance 0.40
Alpha2-HS-glycoprotein was under-expressed in nipple aspirate fluid from tumor-bearing breasts, while lipophilin B, beta-globin, hemopexin, and vitamin D-binding protein precursor were over-expressed [10].


Gene_expression (-) of vitamin D-binding protein precursor in nipple associated with cancer
5) Confidence 0.17 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 0.95 Pain Relevance 0
Alpha2-HS-glycoprotein was under-expressed in nipple aspirate fluid from tumor-bearing breasts, while lipophilin B, beta-globin, hemopexin, and vitamin D-binding protein precursor were over-expressed [10].


Gene_expression (expressed) of vitamin D-binding protein precursor in nipple associated with cancer
6) Confidence 0.17 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 0.95 Pain Relevance 0
Increased complexing of circulating group-specific component (Gc, vitamin D-binding protein) has been found in humans under conditions of presumed increased actin release, and particularly fulminant hepatic necrosis (FHN).
Gene_expression (found) of vitamin D-binding protein associated with necrosis
7) Confidence 0.15 Published 1987 Journal J. Lab. Clin. Med. Section Abstract Doc Link 3598340 Disease Relevance 0.62 Pain Relevance 0.09
DBP, also known as group-specific component globulin (Gc-globulin), is synthesized predominantly by hepatic parenchymal cells [34].
Gene_expression (synthesized) of globulin in parenchymal cells
8) Confidence 0.11 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2730746 Disease Relevance 0.97 Pain Relevance 0.17
DBP, also known as group-specific component globulin (Gc-globulin), is synthesized predominantly by hepatic parenchymal cells [34].
Gene_expression (synthesized) of Gc-globulin in parenchymal cells
9) Confidence 0.11 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2730746 Disease Relevance 0.97 Pain Relevance 0.17
Gc-globulin, another component of the extracellular actin-scavenging system, has also been shown to be present in SF [43], suggesting a system for extracellular actin removal in the inflamed joint.
Gene_expression (present) of Gc-globulin in joint
10) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592804 Disease Relevance 0.48 Pain Relevance 0.17

General Comments

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