INT3777

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Context Info
Confidence 0.56
First Reported 1977
Last Reported 2010
Negated 5
Speculated 4
Reported most in Body
Documents 256
Total Number 267
Disease Relevance 302.43
Pain Relevance 25.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
eyes 52
blood 11
optic 7
plasma 4
meshwork 4
NARFL (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 1224 99.98 Very High Very High Very High
agonist 375 99.96 Very High Very High Very High
Pain 412 99.90 Very High Very High Very High
Central nervous system 413 99.86 Very High Very High Very High
corticosteroid 198 99.72 Very High Very High Very High
ketamine 47 99.68 Very High Very High Very High
ischemia 361 99.66 Very High Very High Very High
fluoxetine 119 99.66 Very High Very High Very High
antagonist 370 99.64 Very High Very High Very High
Migraine 145 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ocular Hypertension 16283 100.00 Very High Very High Very High
Open-angle Glaucoma 198 99.94 Very High Very High Very High
Glaucoma 6346 99.90 Very High Very High Very High
Pain 407 99.90 Very High Very High Very High
Optic Disorders 448 99.88 Very High Very High Very High
Hypertension 271 99.88 Very High Very High Very High
Retina Disease 502 99.84 Very High Very High Very High
Disease Progression 78 99.82 Very High Very High Very High
Cv Unclassified Under Development 556 99.66 Very High Very High Very High
Low Tension Glaucoma 237 99.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this prospective study of patients treated with IVTA injections, we report our findings on the elevated IOP levels and the development of secondary chronic open angle glaucoma.
Positive_regulation (elevated) of IOP associated with open-angle glaucoma and ocular hypertension
1) Confidence 0.56 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 1.02 Pain Relevance 0.04
The significant increase in IOP levels observed in the first hour in our cases was probably due to the volume-effect of the injected IVTA; only 8.8% of the eyes showed a moderately elevated IOP in the first hour postinjection.
Positive_regulation (elevated) of IOP in eyes associated with ocular hypertension
2) Confidence 0.56 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 1.27 Pain Relevance 0
A recent study reported that increases in IOP levels were mostly seen in relatively young patients with uveitis who had received a high dose of IVTA (Jonas 2007).
Positive_regulation (increases) of IOP associated with uveitis and ocular hypertension
3) Confidence 0.56 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 1.18 Pain Relevance 0
Armaly reported that 5% of adult patients were high-responders (increases in IOP >15 mm Hg), and as many as 3% of steroid responders may experience persistent and irreversible IOP elevation (Skuta 1996; Jones 2006).
Positive_regulation (increases) of IOP associated with ocular hypertension
4) Confidence 0.56 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 0.94 Pain Relevance 0.07
The significant increase in IOP levels observed in the first hour in our cases was probably due to the volume-effect of the injected IVTA; only 8.8% of the eyes showed a moderately elevated IOP in the first hour postinjection.
Positive_regulation (increase) of IOP in eyes associated with ocular hypertension
5) Confidence 0.56 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 1.22 Pain Relevance 0
Gillies and colleagues (2006) reported an incidence of IOP elevation (increased by >5 mm Hg) of 68%, significantly higher than observed in previous studies, and rates of topical treatment and glaucoma surgery of 44% and 6%, respectively.
Positive_regulation (elevation) of IOP associated with glaucoma and ocular hypertension
6) Confidence 0.56 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 1.21 Pain Relevance 0
In other studies, approximately a third to a half of all patients receiving IVTA treatment experienced an increase in IOP to above 21 mm Hg (Wingate 1999; Bakri et al 2003; Smithen et al 2004; Jonas et al 2006; Kocabora et al 2007).
Positive_regulation (increase) of IOP associated with ocular hypertension
7) Confidence 0.56 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 1.03 Pain Relevance 0
Corticosteroids are known to elevate the IOP by all routes of administration, but topical use of potent steroids causes IOP elevation in one-third of all eyes treated (Skuta 1996).
Positive_regulation (elevate) of IOP in eyes associated with corticosteroid and ocular hypertension
8) Confidence 0.56 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 0.78 Pain Relevance 0.05
Armaly (1963) reported 46% of glaucoma eyes increased IOP more than 16 mmHg with 0.1% dexamethasone eye drops.
Positive_regulation (increased) of IOP in eyes associated with glaucoma, ocular hypertension and dexamethasone
9) Confidence 0.43 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693970 Disease Relevance 1.29 Pain Relevance 0.05
Jonas and colleagues (2005) found that young age was the only risk factor for elevated IOP after 20 mg IVTA.
Positive_regulation (elevated) of IOP associated with ocular hypertension
10) Confidence 0.43 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693970 Disease Relevance 1.16 Pain Relevance 0
Some patients who were lost to follow up may potentially have had an increase in their IOP and thus would have altered the percentage of patients with IOP rise.
Positive_regulation (increase) of IOP associated with ocular hypertension
11) Confidence 0.43 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693970 Disease Relevance 1.23 Pain Relevance 0
Supine 2 IOP (31 +/- 2 mmHg) decreased in comparison with prone 2 IOP (P < 0.05) but was relatively elevated in comparison with supine 1 and baseline (P < 0.05).
Positive_regulation (elevated) of IOP
12) Confidence 0.40 Published 2001 Journal Anesthesiology Section Body Doc Link 11748391 Disease Relevance 0.05 Pain Relevance 0
CONCLUSIONS: Prone positioning increases IOP during anesthesia.
Positive_regulation (increases) of IOP
13) Confidence 0.40 Published 2001 Journal Anesthesiology Section Body Doc Link 11748391 Disease Relevance 0 Pain Relevance 0
Prone 2 IOP (40 +/- 2 mmHg) was measured after 320 +/- 107 min in the prone position and was significantly increased in comparison with all previous measurements (P < 0.05).
Positive_regulation (increased) of IOP
14) Confidence 0.40 Published 2001 Journal Anesthesiology Section Body Doc Link 11748391 Disease Relevance 0.06 Pain Relevance 0
We carried out trabeculectomies in 3 eyes and pars plana vitrectomies in 2 eyes all with severe IOP increases >40 mm Hg after the first month.
Positive_regulation (increases) of IOP in eyes associated with ocular hypertension
15) Confidence 0.40 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 1.15 Pain Relevance 0
The work of Armaly and Becker suggests that 5%–6% of the population will likely be high responders who develop important IOP elevations early after steroid use, apart from diabetic patients who are also known to be predisposed to IOP rises after steroid treatment (Skuta 1996).
Positive_regulation (important) of IOP associated with diabetes mellitus and ocular hypertension
16) Confidence 0.40 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 1.22 Pain Relevance 0
Topical carbonic anhydrase inhibitors (CAIs) lower IOP by decreasing aqueous production (Maus et al 1997).
Positive_regulation (lower) of IOP associated with ocular hypertension
17) Confidence 0.40 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698680 Disease Relevance 1.32 Pain Relevance 0.08
Two studies (Herse and Siu 1992; Nam et al 2006) reported transient increases in central corneal thickness following the instillation of 0.5% proparacaine hydrochloride, a development which would be expected to induce a transient increase in IOP with the non-contact tonometer (Recep et al 2001; Ko et al 2005).
Positive_regulation (increase) of IOP associated with ocular hypertension
18) Confidence 0.38 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701119 Disease Relevance 0.36 Pain Relevance 0.22
Surprisingly, the IOP levels during the first week after the injection were statistically significantly higher than the preinjection IOP, but only 2.7% of the eyes showed important IOP elevations.
Positive_regulation (elevations) of IOP in eyes associated with ocular hypertension
19) Confidence 0.37 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 1.06 Pain Relevance 0.03
In 40 eyes (27.2%), topical treatment was initiated to reduce the IOP when persistent elevation above 25 mm Hg was observed over one month in weekly examinations after the first observation of IOP ?
Positive_regulation (elevation) of IOP in eyes associated with ocular hypertension
20) Confidence 0.37 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 1.44 Pain Relevance 0

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