INT37799

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Context Info
Confidence 0.56
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 10.59
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apob) transport (Apob) extracellular space (Apob)
extracellular region (Apob) endoplasmic reticulum (Apob) enzyme binding (Apob)
Anatomy Link Frequency
liver 4
plasma 1
body 1
Apob (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 147 99.58 Very High Very High Very High
alcohol 3 97.96 Very High Very High Very High
Inflammation 134 88.08 High High
Angina 2 84.48 Quite High
Pain 12 58.24 Quite High
Inflammatory response 49 47.44 Quite Low
Dismenorea 3 19.88 Low Low
cva 22 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 131 100.00 Very High Very High Very High
Myocardial Infarction 30 99.76 Very High Very High Very High
Familial Combined Hyperlipidemia 4 99.04 Very High Very High Very High
Obesity 283 98.62 Very High Very High Very High
Chronic Disease 7 96.96 Very High Very High Very High
Metabolic Syndrome 8 96.72 Very High Very High Very High
Hypercholesterolemia 22 95.98 Very High Very High Very High
Breast Cancer 25 94.00 High High
Heart Disease 6 93.60 High High
Cardiovascular Disease 25 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The overtrained and recovered groups showed diminished apoB protein expression (p < 0.05) compared with the control group.
Gene_expression (expression) of apoB protein
1) Confidence 0.56 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2959201 Disease Relevance 0.30 Pain Relevance 0.09
Furthermore, increased plasma TAG was accompanied by reduced apoB protein expression in the liver, possibly inducing hepatic steatosis, leading the organism to chronic disease.
Gene_expression (expression) of apoB protein in plasma associated with chronic disease
2) Confidence 0.56 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2959201 Disease Relevance 0.77 Pain Relevance 0.17
Figure 2 shows hepatic apoB (Figure 2a) and TLR-4 (Figure 2b) protein expression.
Gene_expression (expression) of apoB
3) Confidence 0.49 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2959201 Disease Relevance 0.30 Pain Relevance 0.09
In addition, we found increased liver and serum TAG, along with reduced apoB protein expression and IL-6 and IL-10 levels in the of R in relation to the control and trained groups.


Gene_expression (expression) of apoB protein in liver
4) Confidence 0.44 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2959201 Disease Relevance 0.55 Pain Relevance 0.19
Furthermore, we analysed plasma lipid profile, insulin, testosterone, corticosterone and endotoxin levels, and liver triacylglycerol, cytokine content, as well as apolipoprotein B (apoB) and TLR4 expression in the liver.


Gene_expression (expression) of apolipoprotein B in liver associated with disorder of lipid metabolism and cytokine
5) Confidence 0.44 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2959201 Disease Relevance 0.63 Pain Relevance 0.30
Furthermore, we analysed plasma lipid profile, insulin, testosterone, corticosterone and endotoxin levels, and liver triacylglycerol, cytokine content, as well as apolipoprotein B (apoB) and TLR4 expression in the liver.


Gene_expression (expression) of apoB in liver associated with disorder of lipid metabolism and cytokine
6) Confidence 0.44 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2959201 Disease Relevance 0.63 Pain Relevance 0.30
The results also revealed that both IL-6 and IL-10 concentration was reduced in the liver, accompanied by lower apoB protein expression and resulting TAG accumulation (steatosis).
Gene_expression (expression) of apoB protein in liver
7) Confidence 0.44 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2959201 Disease Relevance 0.21 Pain Relevance 0.03
These patients generally have normal levels of LDL-C and apo B levels and can have low levels of HDL-C [12, 13••].
Gene_expression (levels) of apo B associated with disorder of lipid metabolism
8) Confidence 0.26 Published 2010 Journal Curr Diab Rep Section Body Doc Link PMC2890983 Disease Relevance 1.28 Pain Relevance 0
Familial combined hyperlipidemia is also an autosomal-dominant disorder with an overproduction of apo B-100 particles [13••].
Gene_expression (overproduction) of apo B associated with familial combined hyperlipidemia
9) Confidence 0.23 Published 2010 Journal Curr Diab Rep Section Body Doc Link PMC2890983 Disease Relevance 1.37 Pain Relevance 0
After adjustment for age, cigarette consumption, alcohol consumption, and body mass index, subjects with parental history of myocardial infarction had higher levels of total cholesterol (p less than .01), low-density lipoprotein (LDL) cholesterol (p less than .01), and apoprotein B (APOB) (p less than .0001) and a lower level of high-density lipoprotein (HDL) cholesterol (p less than .05) than subjects with no parental history of myocardial infarction.
Gene_expression (levels) of APOB in body associated with obesity, disorder of lipid metabolism, myocardial infarction and alcohol
10) Confidence 0.09 Published 1987 Journal Circulation Section Abstract Doc Link 3608115 Disease Relevance 1.27 Pain Relevance 0.13
Pijlman et al reported that only 21% of the patients with heterozygous hypercholesterolemia in the Netherlands achieved the treatment goal, which required new medical options to be combined with current treatments.53 Mipomersen, a second-generation antisense oligonucleotide, can inhibit the synthesis of apolipoprotein B-100, which is an essential component of all atherogenic lipoproteins such as LDL and has been used to lower cholesterol level in patients with hypercholesterolemia.54 In a multicenter, randomized, double-blind, placebo-controlled trial, Raal et al used mipomersen to treat patients with homozygous familial hypercholesterolemia older than 12 years who were already receiving maximum tolerated doses of lipid-lowering drugs.55 They injected 200 mg mipomersen subcutaneously every week for 26 weeks to a treatment group and compared them with those who received placebo.
Gene_expression (synthesis) of apolipoprotein B-100 associated with hyperlipoproteinemia type ii, disorder of lipid metabolism and hypercholesterolemia
11) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC3004511 Disease Relevance 0.54 Pain Relevance 0
Anastrozole induced no significant change of serum levels of apolipoprotein A1, apolipoprotein B, triglycerides, total cholesterol, HDL-C, and LDL-C.
Gene_expression (levels) of apolipoprotein B associated with disorder of lipid metabolism
12) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503653 Disease Relevance 1.79 Pain Relevance 0
Data on the LDL cholesterol–to-PON concentration ratio or levels of LDL cholesterol, triglycerides, and apolipoprotein B were not available for this study.
Gene_expression (levels) of apolipoprotein B associated with disorder of lipid metabolism
13) Confidence 0.01 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494642 Disease Relevance 0.55 Pain Relevance 0.06

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