INT37800

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Context Info
Confidence 0.18
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 11.01
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apob) transport (Apob) extracellular space (Apob)
extracellular region (Apob) endoplasmic reticulum (Apob) enzyme binding (Apob)
Anatomy Link Frequency
coronary artery 1
liver 1
skeletal muscle 1
heart 1
Apob (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 4 96.00 Very High Very High Very High
cINOD 6 92.20 High High
Clonidine 1 87.24 High High
Inflammation 36 84.48 Quite High
alcohol 2 58.76 Quite High
Angina 1 47.32 Quite Low
cva 41 5.00 Very Low Very Low Very Low
Pain 22 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
spinal inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 126 100.00 Very High Very High Very High
Overweight 6 99.84 Very High Very High Very High
Coronary Artery Disease 18 99.78 Very High Very High Very High
Cardiovascular Disease 55 99.68 Very High Very High Very High
Abdominal Obesity 3 99.60 Very High Very High Very High
Obesity 24 99.28 Very High Very High Very High
Myocardial Infarction 27 98.96 Very High Very High Very High
Insulin Resistance 66 98.92 Very High Very High Very High
Hypertriglyceridemia 1 98.78 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 28 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When pure F was used instead of HFCS, no postprandial HTG was observed for oral intakes up to approximately 50 g/d.17 HTG and fasting ApoB was, however, increased in overweight or obese women.18 Fasting increased levels of TG, VLDL-TAG and leptin without inducing insulin resistance or ectopic fat deposition in healthy males after four weeks of HF administration.19 More recently, however, the same group reported that just one week of HF administration increased ectopic fat deposition in the liver and skeletal muscle, with a greater effect seen in the offspring of diabetic parents than in healthy controls.20
Positive_regulation (increased) of ApoB in liver associated with diabetes mellitus, obesity, insulin resistance and overweight
1) Confidence 0.18 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910863 Disease Relevance 1.01 Pain Relevance 0
These patients are at increased risk for premature coronary artery disease (CAD) and have elevated apo B levels [13••].
Positive_regulation (elevated) of apo B in coronary artery associated with coronary artery disease and cardiovascular disease
2) Confidence 0.16 Published 2010 Journal Curr Diab Rep Section Body Doc Link PMC2890983 Disease Relevance 1.64 Pain Relevance 0
We conclude that part of the known relationship between parental history of myocardial infarction and coronary heart disease could be mediated by an increased APOB level.
Positive_regulation (increased) of APOB in heart associated with coronary artery disease and myocardial infarction
3) Confidence 0.09 Published 1987 Journal Circulation Section Abstract Doc Link 3608115 Disease Relevance 0.99 Pain Relevance 0.03
When pure F was used instead of HFCS, no postprandial HTG was observed for oral intakes up to approximately 50 g/d.17 HTG and fasting ApoB was, however, increased in overweight or obese women.18 Fasting increased levels of TG, VLDL-TAG and leptin without inducing insulin resistance or ectopic fat deposition in healthy males after four weeks of HF administration.19 More recently, however, the same group reported that just one week of HF administration increased ectopic fat deposition in the liver and skeletal muscle, with a greater effect seen in the offspring of diabetic parents than in healthy controls.20
Positive_regulation (increased) of ApoB in skeletal muscle associated with diabetes mellitus, obesity, insulin resistance and overweight
4) Confidence 0.06 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910863 Disease Relevance 1.01 Pain Relevance 0
When compared to controls (n = 29), proteinuric patients before treatment showed increased levels of total cholesterol, very-low and low-density lipoprotein (VLDL+LDL) cholesterol, triglycerides and apolipoprotein B (apoB), while high-density lipoprotein (HDL) HDL cholesterol was lower.
Positive_regulation (increased) of apolipoprotein B associated with disorder of lipid metabolism
5) Confidence 0.05 Published 1994 Journal Nephrol. Dial. Transplant. Section Abstract Doc Link 8052429 Disease Relevance 1.04 Pain Relevance 0.34
Results showed a significant increase in total cholesterol (p 0.05), LDL-C (p < 0.01) and apolipoprotein B levels (p = 0.05) after 16 weeks of treatment.
Positive_regulation (increase) of apolipoprotein B associated with disorder of lipid metabolism
6) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503653 Disease Relevance 1.50 Pain Relevance 0
Exposure to exemestane resulted in a significant increase of the atherogenic ratios LDL-C/HDL-C and apolipoprotein B/apolipoprotein A1, compared to anastrozole and letrozole.
Positive_regulation (increase) of apolipoprotein B associated with disorder of lipid metabolism
7) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503653 Disease Relevance 0.76 Pain Relevance 0
MetS describes a constellation of cardiovascular risk factors such as atherogenic dyslipidemia (increased free fatty acids, elevated triglycerides, low high-density lipoprotein [HDL] cholesterol levels, and increased small dense low-density lipoprotein [LDL] and apolipoprotein B levels), central obesity, insulin resistance, disturbed glucose metabolism (T2DM, impaired glucose tolerance, and impaired fasting glycemia), and hypertension [3].
Positive_regulation (increased) of apolipoprotein B associated with diabetes mellitus, metabolic syndrome, insulin resistance, impaired glucose tolerance, hypertriglyceridemia, abdominal obesity, hypertension, tolerance and disorder of lipid metabolism
8) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483433 Disease Relevance 2.63 Pain Relevance 0.12

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