INT37803

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Context Info
Confidence 0.68
First Reported 1987
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 14.21
Pain Relevance 13.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bdkrb2) plasma membrane (Bdkrb2) signal transducer activity (Bdkrb2)
Anatomy Link Frequency
DRG 2
nociceptors 2
blood 1
joint 1
trigeminal ganglia 1
Bdkrb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 570 100.00 Very High Very High Very High
B1 receptor 108 100.00 Very High Very High Very High
b2 receptor 103 100.00 Very High Very High Very High
agonist 153 99.96 Very High Very High Very High
dorsal root ganglion 377 99.84 Very High Very High Very High
Inflammation 300 99.70 Very High Very High Very High
Arthritis 344 99.56 Very High Very High Very High
Neuropeptide 23 98.76 Very High Very High Very High
Pain 147 98.36 Very High Very High Very High
nociceptor 20 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 12 99.96 Very High Very High Very High
INFLAMMATION 292 99.70 Very High Very High Very High
Arthritis 384 99.56 Very High Very High Very High
Ganglion Cysts 384 99.36 Very High Very High Very High
Cancer 101 99.26 Very High Very High Very High
Pain 133 98.36 Very High Very High Very High
Obesity 38 98.22 Very High Very High Very High
Arthralgia 6 97.60 Very High Very High Very High
Hyperalgesia 85 95.88 Very High Very High Very High
Neuropathic Pain 70 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One such neuropeptide, bradykinin (BK), is an important inflammatory mediator that activates the type-2 BK receptor (B2R) on the terminal endings of specialized pain-sensing neurons known as nociceptors.
Positive_regulation (activates) of type-2 BK receptor in nociceptors associated with pain, inflammation, nociceptor, neuropeptide and bradykinin
1) Confidence 0.68 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16515556 Disease Relevance 0.27 Pain Relevance 0.60
One such neuropeptide, bradykinin (BK), is an important inflammatory mediator that activates the type-2 BK receptor (B2R) on the terminal endings of specialized pain-sensing neurons known as nociceptors.
Positive_regulation (activates) of B2R in nociceptors associated with pain, inflammation, nociceptor, neuropeptide and bradykinin
2) Confidence 0.68 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16515556 Disease Relevance 0.27 Pain Relevance 0.60
Furthermore, the treatment of primary cultures of trigeminal ganglia with inhibitors of EP24.15/16 led to the potentiation of several bradykinin-induced events that occur downstream of B2R activation.
Positive_regulation (activation) of B2R in trigeminal ganglia associated with bradykinin
3) Confidence 0.68 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16515556 Disease Relevance 0.21 Pain Relevance 0.57
EP24.15/16 inhibition by N-[1(R,S)-carboxy-3-phenylpropyl]-Ala-AlalTyr-p-aminobenzoate (cFP) resulted in a 1000-fold increase in B2R sensitivity to BK as measured by inositol phosphate accumulation.
Positive_regulation (increase) of B2R associated with bradykinin
4) Confidence 0.59 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16515556 Disease Relevance 0.20 Pain Relevance 0.54
These results suggest that BK may play a role through the activation of a B2-receptor type in a spinal sensory pathway subserving pain.
Positive_regulation (activation) of B2-receptor in spinal associated with pain and bradykinin
5) Confidence 0.59 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3609147 Disease Relevance 0.17 Pain Relevance 1.00
We conclude that B1 and B2 receptor mRNA are differentially expressed in the hypothalamus of SHR and may play different roles in the pathogenesis of hypertension: upregulation of B2 receptor mRNA from early age may participate in the pathogenesis of hypertension, whereas an upregulation of B1 receptor mRNA in the established phase of hypertension may reflect an epiphenomenon in essential hypertension.
Positive_regulation (upregulation) of B2 receptor in hypothalamus associated with b1 receptor, hypertension and b2 receptor
6) Confidence 0.55 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 12025958 Disease Relevance 1.09 Pain Relevance 0.39
In DRG, B1R and B2R binding sites were significantly increased at 2 days (ipsilateral) and 14 days on both sides.
Positive_regulation (increased) of B2R in DRG
7) Confidence 0.47 Published 2008 Journal Int. Immunopharmacol. Section Abstract Doc Link 18182225 Disease Relevance 0.81 Pain Relevance 1.03
As seen in the case of blood Gd-DTPA concentration curves, the degree of increase in half-life of Gd-DTPA in the extravascular tumor space correlated with the metabolic stability of bradykinin B2 agonist (Figure, 5A through 5E).
Positive_regulation (stability) of bradykinin B2 in blood associated with cancer, agonist and bradykinin
8) Confidence 0.45 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 1.17 Pain Relevance 0.10
The B2R is widely and constitutively expressed in central and peripheral tissues and is activated by its preferential agonists bradykinin (BK) and Lys-BK.
Positive_regulation (activated) of B2R associated with agonist and bradykinin
9) Confidence 0.29 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 2.16 Pain Relevance 1.43
We recently reported that both neurokinin 1 receptors and bradykinin 2 receptors are upregulated in dorsal root ganglion (DRG) neurones (the cell bodies of sensory fibres) in the course of acute and chronic antigen-induced arthritis in the rat.
Positive_regulation (upregulated) of bradykinin 2 in DRG associated with ganglion cysts, dorsal root ganglion, bradykinin and arthritis
10) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860064 Disease Relevance 0.84 Pain Relevance 0.65
Upregulation of neurokinin 1 receptors but not of bradykinin 2 and TRPV1 receptors was also observed when only the supernatant of FLS cells from acutely inflamed joint was added to DRG neurones.
Positive_regulation (Upregulation) of bradykinin 2 in joint associated with dorsal root ganglion and bradykinin
11) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860064 Disease Relevance 1.20 Pain Relevance 0.89
This depended on the B2 receptor, PLC activation, and inositol triphosphate-mediated Ca2+ release.
Positive_regulation (depended) of B2 receptor associated with b2 receptor
12) Confidence 0.16 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17485565 Disease Relevance 0.38 Pain Relevance 0.67
This depended on the B2 receptor, PLC activation, and inositol triphosphate-mediated Ca2+ release.
Positive_regulation (activation) of B2 receptor associated with b2 receptor
13) Confidence 0.16 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17485565 Disease Relevance 0.38 Pain Relevance 0.67
Only the B2 receptor, not the B1 receptor, was upregulated.
Positive_regulation (upregulated) of B2 receptor associated with b1 receptor and b2 receptor
14) Confidence 0.14 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17819 Disease Relevance 1.35 Pain Relevance 1.45
Thirdly, and unexpectedly, only the B2 receptor, not the B1 receptor, was upregulated.
Positive_regulation (upregulated) of B2 receptor associated with b1 receptor and b2 receptor
15) Confidence 0.14 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17819 Disease Relevance 1.56 Pain Relevance 1.49
We therefore conclude that the increased expression of BK receptors in AIA is entirely due to an upregulation of the B2 receptor.


Positive_regulation (upregulation) of B2 receptor associated with b2 receptor, bradykinin and arthritis
16) Confidence 0.14 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17819 Disease Relevance 0.93 Pain Relevance 1.27
The algesic effects of the venom are entirely due to direct B2 receptor activation.
Positive_regulation (activation) of B2 receptor associated with b2 receptor
17) Confidence 0.09 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9698210 Disease Relevance 0.47 Pain Relevance 0.47
In a similar independent study, it was found that Omapatrilat, a vasopeptidase inhibitor, induced insulin sensitization and increased myocardial glucose uptake in obese Zucker rats and that the effect of Omapatrilat was greater than Ramipril in part due to stimulation of the B2 receptor [45].
Positive_regulation (stimulation) of B2 receptor associated with obesity and b2 receptor
18) Confidence 0.07 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2933895 Disease Relevance 0.76 Pain Relevance 0.15

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