INT37811

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Context Info
Confidence 0.47
First Reported 1986
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 4.65
Pain Relevance 3.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SERPINB6) protein complex (SERPINB6) cytoplasm (SERPINB6)
SERPINB6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Endep 3 99.00 Very High Very High Very High
ischemia 18 98.94 Very High Very High Very High
Pain score 14 97.40 Very High Very High Very High
Pain 153 97.36 Very High Very High Very High
nociceptor 14 96.76 Very High Very High Very High
headache 6 96.60 Very High Very High Very High
Migraine 6 94.92 High High
Antinociceptive 1 94.92 High High
Serotonin 1 88.56 High High
analgesia 5 87.40 High High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 16 98.94 Very High Very High Very High
Pain 159 97.40 Very High Very High Very High
Headache 9 96.60 Very High Very High Very High
Obesity 28 87.80 High High
Metatarsalgia 189 84.80 Quite High
Parkinson's Disease 2 80.56 Quite High
Body Weight 7 78.52 Quite High
Migraine Without Aura 3 76.92 Quite High
Congenital Anomalies 1 76.08 Quite High
Peripheral Arterial Disease 21 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Replacement or changing to different-sized MPs should be considered when MP placement fails to achieve PTI and MPP reduction by insole plantar pressure measurement.
Negative_regulation (reduction) of PTI
1) Confidence 0.47 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712337 Disease Relevance 0.19 Pain Relevance 0.14
MP application decreased the maximal peak pressure (MPP) and pressure-time integral (PTI) under the second MH and also statistically improved subjective pain scores.
Negative_regulation (decreased) of PTI associated with pain score
2) Confidence 0.40 Published 2006 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC1712337 Disease Relevance 0.67 Pain Relevance 0.23
We found that the declines in the PTI and MPP under the MH after MP application correlated with significant pain improvement.
Negative_regulation (declines) of PTI associated with pain
3) Confidence 0.35 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712337 Disease Relevance 0.22 Pain Relevance 0.16
We found that the decline in the MPP and PTI after MP placement differed significantly in each outcome group (p = 0.033 and p = 0.034, respectively).
Negative_regulation (decline) of PTI
4) Confidence 0.35 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712337 Disease Relevance 0 Pain Relevance 0
Based on our findings, we suggest that the optimal treatment should be lowering the PTI under the MH as much as possible.
Spec (possible) Negative_regulation (lowering) of PTI
5) Confidence 0.35 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712337 Disease Relevance 0.56 Pain Relevance 0.60
We found that the successful decline in the PTI and MPP under the second MH after MP application was correlated to subjective pain improvement.
Negative_regulation (decline) of PTI associated with pain
6) Confidence 0.35 Published 2006 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC1712337 Disease Relevance 0.56 Pain Relevance 0.23
A significant correlation between percentage increase in RIII reflex threshold and reduction of PTI was also observed after amitriptyline treatment, indicating that pain reflex may be used for predicting treatment response in migraine.
Negative_regulation (reduction) of PTI associated with pain, migraine and endep
7) Confidence 0.30 Published 1986 Journal Funct. Neurol. Section Abstract Doc Link 3609872 Disease Relevance 1.63 Pain Relevance 1.62
After MP placement, the MPP and PTI of all the subjects decreased significantly; their values were 199.0 (95% CI, 163.3–234.8) kPa and 31.9 (95% CI, 24.3–39.5) kPa·s, respectively.
Negative_regulation (decreased) of PTI
8) Confidence 0.15 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712337 Disease Relevance 0.40 Pain Relevance 0
Although ischemia results in decreased glucose supply coinciding with reduced ptiO2 and resulting in decreased cerebral glucose levels, mitochondrial damage is accepted to deviate glucose degradation via oxidative phosphorylation to glycolysis within the cytosolic compartment even under conditions of sufficient perfusion and sufficient ptiO2.
Negative_regulation (reduced) of ptiO2 associated with ischemia
9) Confidence 0.01 Published 2010 Journal Crit Care Section Body Doc Link PMC2875528 Disease Relevance 0.19 Pain Relevance 0.10
A decrease in ptiO2 from any starting point would be expected to result in reduced glucose supply.
Negative_regulation (decrease) of ptiO2
10) Confidence 0.01 Published 2010 Journal Crit Care Section Body Doc Link PMC2875528 Disease Relevance 0.23 Pain Relevance 0.07

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