INT37834

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Context Info
Confidence 0.58
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 6.22
Pain Relevance 5.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
leukocyte 2
brain 2
head 2
neural 2
CPP (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 315 100.00 Very High Very High Very High
Morphine 35 100.00 Very High Very High Very High
narcan 2 99.84 Very High Very High Very High
adenocard 5 99.16 Very High Very High Very High
Central grey 9 97.92 Very High Very High Very High
Neurotransmitter 12 97.20 Very High Very High Very High
Ventral tegmentum 8 97.20 Very High Very High Very High
Raphe 2 96.32 Very High Very High Very High
anesthesia 9 94.36 High High
Nucleus accumbens 2 93.00 High High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 299 100.00 Very High Very High Very High
Brain Injury 35 100.00 Very High Very High Very High
Bacterial Meningitis 21 98.72 Very High Very High Very High
Hypocapnia 2 98.56 Very High Very High Very High
Cv General 4 Under Development 21 98.24 Very High Very High Very High
Hemorrhage 13 98.08 Very High Very High Very High
Urological Neuroanatomy 10 97.92 Very High Very High Very High
Brain Tumor 3 97.16 Very High Very High Very High
INFLAMMATION 27 91.92 High High
Meningitis 27 88.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that MK-801 not only blocks the development of morphine-induced CPP but is also able to block the expression of a conditioned response that has been acquired before.
Negative_regulation (blocks) of Positive_regulation (induced) of CPP associated with morphine
1) Confidence 0.58 Published 1997 Journal Behav. Brain Res. Section Abstract Doc Link 9079776 Disease Relevance 0 Pain Relevance 0.90
Furthermore, pregabalin blocked the maintenance of morphine-induced CPP.
Negative_regulation (blocked) of Positive_regulation (induced) of CPP
2) Confidence 0.51 Published 2001 Journal Psychopharmacology (Berl.) Section Body Doc Link 11605097 Disease Relevance 0 Pain Relevance 0
In a second experiment, it was found that pregabalin (injected once, 24 h after CPP had been demonstrated) was able to reverse morphine-induced CPP.
Negative_regulation (reverse) of Positive_regulation (induced) of CPP
3) Confidence 0.51 Published 2001 Journal Psychopharmacology (Berl.) Section Body Doc Link 11605097 Disease Relevance 0 Pain Relevance 0
This study examined the neural substrates underlying the development of a conditioned place preference (CPP) to morphine (2 mg/kg x 3 pairings) by testing whether lesions of 7 different neural sites block a morphine-induced CPP.
Spec (whether) Negative_regulation (block) of Spec (whether) Positive_regulation (induced) of CPP in neural associated with morphine
4) Confidence 0.45 Published 1997 Journal Behav. Neurosci. Section Abstract Doc Link 9438800 Disease Relevance 0.27 Pain Relevance 0.68
RESULTS: Pretreatment with either gabapentin (10-100 mg/kg p.o.) or pregabalin (3-30 mg/kg p.o.) attenuated CPP induced by a submaximal dose of morphine (0.75 mg/kg).
Negative_regulation (attenuated) of Positive_regulation (induced) of CPP
5) Confidence 0.37 Published 2001 Journal Psychopharmacology (Berl.) Section Body Doc Link 11605097 Disease Relevance 0 Pain Relevance 0
The CPP was either increased in 10-torr increments using norepinephrine or decreased by a combination of adenosine triphosphate and hemorrhage in subgroups.
Negative_regulation (decreased) of Positive_regulation (increased) of CPP associated with adenocard and cva
6) Confidence 0.32 Published 1987 Journal J. Neurosurg. Section Abstract Doc Link 3612269 Disease Relevance 0.10 Pain Relevance 0.27
Ranolazine (10 microM) significantly reduced the PC-induced increase in LVEDP by 72 +/- 6% (n = 6, p < 0.001), reduced left ventricular wall stiffness, and attenuated the PC-induced increase of CPP by 53 +/- 10% (n = 6-7, p < 0.05).
Negative_regulation (attenuated) of Positive_regulation (increase) of CPP
7) Confidence 0.12 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19403851 Disease Relevance 0.07 Pain Relevance 0.18
TTX (2 microM) significantly (p < 0.05) reduced PC-induced increases of CPP and LVEDP.
Negative_regulation (reduced) of Positive_regulation (increases) of CPP
8) Confidence 0.12 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19403851 Disease Relevance 0.07 Pain Relevance 0.16
In the present study, HTS infusion significantly decreased lactate level and leukocyte count in the CSF, and increased CPP in the newborn piglet model of bacterial meningitis.
Negative_regulation (decreased) of Positive_regulation (increased) of CPP in leukocyte associated with bacterial meningitis
9) Confidence 0.08 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779288 Disease Relevance 1.10 Pain Relevance 0.25
The CPP induced by systemic morphine (4 mg/kg x 1 pairing) was blocked by naloxone methiodide (NM) injected (2 nmol in 0.5 microl) into the VTA.
Negative_regulation (blocked) of Positive_regulation (induced) of CPP associated with ventral tegmentum, narcan and morphine
10) Confidence 0.07 Published 1997 Journal Behav. Neurosci. Section Abstract Doc Link 9438801 Disease Relevance 0.61 Pain Relevance 1.29
Suarez et al. [48] reported a significant decrease of ICP and increase of CPP in these patients, when application of mannitol had been previously unsuccessful.
Negative_regulation (decrease) of Positive_regulation (increase) of CPP associated with cva
11) Confidence 0.07 Published 2005 Journal Crit Care Section Body Doc Link PMC1297608 Disease Relevance 1.45 Pain Relevance 0.46
Suarez et al. [48] reported a significant decrease of ICP and increase of CPP in these patients, when application of mannitol had been previously unsuccessful.
Negative_regulation (decrease) of Positive_regulation (increase) of CPP associated with cva
12) Confidence 0.05 Published 2005 Journal Crit Care Section Body Doc Link PMC1297608 Disease Relevance 1.45 Pain Relevance 0.46
He found, in rats with induced head injury, a similar positive effect on ICP with regards to the amount and duration of the decrease, but a higher CPP in the rats receiving mannitol.
Negative_regulation (effect) of Positive_regulation (induced) of CPP in head associated with cva and brain injury
13) Confidence 0.05 Published 2005 Journal Crit Care Section Body Doc Link PMC1297608 Disease Relevance 0.85 Pain Relevance 0.27
The increase of acetylcholine in the brain of ache mutants causes a decrease in amphetamine-induced CPP [13].
Negative_regulation (decrease) of Positive_regulation (induced) of CPP in brain
14) Confidence 0.02 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2919542 Disease Relevance 0 Pain Relevance 0.50
Hypocapnia did not change eCPP or ZFP in the propofol group, but it significantly decreased eCPP and increased ZFP in the sevoflurane group.
Negative_regulation (decreased) of Positive_regulation (increased) of eCPP associated with hypocapnia
15) Confidence 0.01 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15728076 Disease Relevance 0.26 Pain Relevance 0.26

General Comments

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