INT37835

Context Info Confidence 0.51 First Reported 1987 Last Reported 2010 Negated 1 Speculated 2 Reported most in Abstract Documents 61 Total Number 64 Disease Relevance 31.34 Pain Relevance 18.57

Anatomy Link Frequency brain 6 CSF 3 leukocyte 2 blood 1 spinal 1 CPP (Homo sapiens)

Pain Link Frequency Relevance Heat cva 1177 100.00 Morphine 69 100.00 Pain 36 100.00 anesthesia 75 99.98 ischemia 120 99.88 narcan 7 99.84 Central grey 15 99.56 Clonidine 5 99.46 Inflammatory response 92 99.44 rapifen 27 99.38

Disease Link Frequency Relevance Heat Cv General 3 Under Development 1079 100.00 Pain 31 100.00 Cv General 4 Under Development 148 99.88 Endotoxemia 12 99.82 Cerebral Hypoxia 30 99.56 Urological Neuroanatomy 17 99.56 Stupor 2 99.38 Brain Death 10 99.28 INFLAMMATION 175 99.24 Pneumoperitoneum 16 99.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In a second experiment, it was found that pregabalin (injected once, 24 h after CPP had been demonstrated) was able to reverse morphine-induced CPP.

Negative_regulation (reverse) of CPP

1) Confidence 0.51 Published 2001 Journal Psychopharmacology (Berl.) Section Body Doc Link 11605097 Disease Relevance 0 Pain Relevance 0

CONCLUSIONS: The results of this study suggest that interstitial cystitis is an etiology of CPP in young women.

Negative_regulation (etiology) of CPP

2) Confidence 0.42 Published 2009 Journal J Pediatr Adolesc Gynecol Section Body Doc Link 19539205 Disease Relevance 0 Pain Relevance 0

At same times, a significant (P<0.01) decrease in severity of CPP and deep dyspareunia was observed in both groups with no difference between them.

Negative_regulation (decrease) of CPP

3) Confidence 0.39 Published 2006 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Body Doc Link 16442203 Disease Relevance 0.07 Pain Relevance 0

Buprenorphine CPP was also blocked by coadministration of naltrindole (3.16 mg/kg IP), nor-binaltorphimine (4.64 mg/kg SC), and naloxonebenzoylhydrazone (0.464 mg/kg SC).

Negative_regulation (blocked) of CPP

4) Confidence 0.37 Published 2004 Journal Psychopharmacology (Berl.) Section Body Doc Link 14615874 Disease Relevance 0 Pain Relevance 0

RESULTS: Pretreatment with either gabapentin (10-100 mg/kg p.o.) or pregabalin (3-30 mg/kg p.o.) attenuated CPP induced by a submaximal dose of morphine (0.75 mg/kg).

Negative_regulation (attenuated) of CPP

5) Confidence 0.37 Published 2001 Journal Psychopharmacology (Berl.) Section Body Doc Link 11605097 Disease Relevance 0 Pain Relevance 0

A first group of low ti-pO2 episodes was clearly related to an insufficient CPP level (n = 13), comprising 4 cases of parallel decrease in CPP and ti-pO2 until brain death, and 9 cases in which ti-pO2 was restored along with a significant increase in CPP (p < 0.001).

Negative_regulation (decrease) of CPP in brain associated with brain death

6) Confidence 0.37 Published 1998 Journal Neurol. Res. Section Abstract Doc Link 9584925 Disease Relevance 0.53 Pain Relevance 0.08

Infusion of diprivan at the initial stage of narcosis in a dose of 2 mg/kg led to a decrease in arterial pressure, mean arterial pressure, CPP, and ICP.

Negative_regulation (decrease) of CPP associated with stupor

7) Confidence 0.37 Published 2001 Journal Anesteziol Reanimatol Section Abstract Doc Link 11494900 Disease Relevance 0.29 Pain Relevance 0.17

With sevoflurane, decreased Vmca was accompanied by decreased CPP and unchanged CVRe at 0.5 MAC, and unchanged CPP and increased CVRe at 1.0 and 1.5 MAC.

Negative_regulation (decreased) of CPP

8) Confidence 0.37 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9296414 Disease Relevance 0.37 Pain Relevance 0.40

With Valsalva maneuvers, the maximum CSFP produced was 13 +/- 4 mm Hg, and the CPP decreased to 50 +/- 14 mm Hg, whereas with saline, the maximum CSFP was 25 +/- 7 mm Hg, and the CPP decreased to 59 +/- 13 mm Hg.

Negative_regulation (decreased) of CPP

9) Confidence 0.37 Published 1995 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 7881234 Disease Relevance 0.14 Pain Relevance 0.31

With Valsalva maneuvers, the maximum CSFP produced was 13 +/- 4 mm Hg, and the CPP decreased to 50 +/- 14 mm Hg, whereas with saline, the maximum CSFP was 25 +/- 7 mm Hg, and the CPP decreased to 59 +/- 13 mm Hg.

Negative_regulation (decreased) of CPP

10) Confidence 0.37 Published 1995 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 7881234 Disease Relevance 0.15 Pain Relevance 0.32

During the preinduction period, clonidine had no effect on ICP or HR, but in clonidine-treated patients, MAP and CPP decreased significantly in comparison to those of the placebo group.

Negative_regulation (decreased) of CPP associated with cva and clonidine

11) Confidence 0.37 Published 1995 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 7549366 Disease Relevance 0.73 Pain Relevance 0.86

By analysis of variance with repeated measures, data demonstrated that the alfentanil trials were associated with a decline in the CPP relative to control.

Negative_regulation (decline) of CPP associated with rapifen

12) Confidence 0.37 Published 1993 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 8431667 Disease Relevance 0.42 Pain Relevance 0.52

However, because this technique can decrease the CPP excessively, we recommend that it be used only with continuous CSFP monitoring.

Negative_regulation (decrease) of CPP

13) Confidence 0.37 Published 1995 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 7881234 Disease Relevance 0.18 Pain Relevance 0.31

The CPP was significantly reduced (p < 0.05) in the alfentanil dosage trials 5 min after i.v. alfentanil injection.

Negative_regulation (reduced) of CPP associated with rapifen

14) Confidence 0.37 Published 1993 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 8431667 Disease Relevance 0.41 Pain Relevance 0.53

Our aim was to determine prevalence of CPP following LIHR and identify risk factors for its development.

Spec (determine) Negative_regulation (prevalence) of CPP associated with pain

15) Confidence 0.37 Published 2008 Journal Hernia Section Abstract Doc Link 18661098 Disease Relevance 0.62 Pain Relevance 0.36

Surviving patients have decreased ICP, increased CPP, decreased CAP Index, increased StcO2, and increased BIS.

Negative_regulation (decreased) of CPP associated with cva

16) Confidence 0.35 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.14 Pain Relevance 0.54

Key messages • Noninvasive BIS and StcO2 values are clinically relevant with severe brain injury. • ICP, BIS, and StcO2 values provide complementary information. • When ICP increases or CPP decreases, there is cerebral hypoxia and altered brain wave patterns. • Future studies will determine the therapeutic and diagnostic benefit of BIS and StcO2 monitoring. • CAP Index is a discriminate relationship between ICP and MAP that has prognostic and therapeutic implications.

Negative_regulation (decreases) of CPP in brain associated with cerebral hypoxia, cva and brain injury

17) Confidence 0.35 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.44 Pain Relevance 0.48

This study examined the neural substrates underlying the development of a conditioned place preference (CPP) to morphine (2 mg/kg x 3 pairings) by testing whether lesions of 7 different neural sites block a morphine-induced CPP.

Spec (whether) Negative_regulation (block) of CPP in neural associated with morphine

18) Confidence 0.33 Published 1997 Journal Behav. Neurosci. Section Abstract Doc Link 9438800 Disease Relevance 0.27 Pain Relevance 0.68

Relative to controls, attenuation of CPP was evident in animals exposed to 16-mg lead at 1.25 and 2.50 mg/kg morphine.

Negative_regulation (attenuation) of CPP associated with morphine

19) Confidence 0.31 Published 2003 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12873619 Disease Relevance 0 Pain Relevance 0.41

Racemic bupivacaine and R(+)-bupivacaine produced similar dose-dependent decreases in CPP.

Negative_regulation (decreases) of CPP

20) Confidence 0.31 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15728056 Disease Relevance 0 Pain Relevance 0.18

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