INT37838

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Context Info
Confidence 0.27
First Reported 1987
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.67
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp27b1) oxidoreductase activity (Cyp27b1) aging (Cyp27b1)
cytoplasm (Cyp27b1)
Anatomy Link Frequency
liver 1
Cyp27b1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 8 99.42 Very High Very High Very High
opioid receptor 4 96.12 Very High Very High Very High
narcan 2 95.20 Very High Very High Very High
Morphine 6 92.72 High High
Opioid 4 75.00 Quite High
Antinociceptive 4 69.04 Quite High
Potency 4 67.76 Quite High
headache 1 47.92 Quite Low
agonist 16 42.36 Quite Low
nociceptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 36 98.68 Very High Very High Very High
Nicotine Addiction 16 59.60 Quite High
Headache 1 47.92 Quite Low
Gastrointestinal Disease 1 47.40 Quite Low
Obesity 6 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 4 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicated that rutaecarpine was a CYP1A inducer and showed potent inductive effects on both CYP1A1 and CYP1A2 in the liver.
Regulation (effects) of CYP1A1 in liver
1) Confidence 0.27 Published 2001 Journal Life Sci. Section Abstract Doc Link 11787945 Disease Relevance 0 Pain Relevance 0
In the evaluation of their inhibitory effects to enkephalin-degrading enzymes, the IC50 values of H-Tyr-D-Arg-Phe-Gly-OH, H-Tyr-D-Arg-Phe-Sar-OH and H-Tyr-D-Ala-Phe-Gly-OH were 5.4, 14.5 and more than 50.0 microM, respectively (bestatin = 0.1 microM) against aminopeptidase and 1.18, 1.40 and more than 50.0 microM, respectively (captopril = 0.38 and D-Phe-2S-, 3R-3-amino-2-hydroxy-4-phenylbutanoic acid = more than 100 microM) against the cleaving enzymes of enkephalin at its Gly3-Phe4 bond.
Regulation (values) of H-Tyr-D-Arg-Phe-Sar-OH associated with enkephalin
2) Confidence 0.14 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3612556 Disease Relevance 0 Pain Relevance 0.81
In the evaluation of their inhibitory effects to enkephalin-degrading enzymes, the IC50 values of H-Tyr-D-Arg-Phe-Gly-OH, H-Tyr-D-Arg-Phe-Sar-OH and H-Tyr-D-Ala-Phe-Gly-OH were 5.4, 14.5 and more than 50.0 microM, respectively (bestatin = 0.1 microM) against aminopeptidase and 1.18, 1.40 and more than 50.0 microM, respectively (captopril = 0.38 and D-Phe-2S-, 3R-3-amino-2-hydroxy-4-phenylbutanoic acid = more than 100 microM) against the cleaving enzymes of enkephalin at its Gly3-Phe4 bond.
Regulation (values) of H-Tyr-D-Arg-Phe-Gly-OH associated with enkephalin
3) Confidence 0.14 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3612556 Disease Relevance 0 Pain Relevance 0.80
For example, Mattingly et al. (2001) generated transgenic zebrafish that express green fluorescent protein (GFP) under the control of the human CYP1A1 promoter/enhancer.
Regulation (control) of CYP1A1 associated with targeted disruption
4) Confidence 0.04 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.34 Pain Relevance 0
For example, Mattingly et al. (2001) generated transgenic zebrafish that express green fluorescent protein (GFP) under the control of the human CYP1A1 promoter/enhancer.
Regulation (control) of CYP1A1 associated with targeted disruption
5) Confidence 0.04 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.34 Pain Relevance 0

General Comments

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