INT37839

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Context Info
Confidence 0.01
First Reported 1987
Last Reported 1987
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.86

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cytoplasm (Cyp27b1, Oprd1) mitochondrion (Cyp27b1) oxidoreductase activity (Cyp27b1)
aging (Cyp27b1) plasma membrane (Oprd1) signal transducer activity (Oprd1)
Cyp27b1 (Mus musculus)
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 2 100.00 Very High Very High Very High
Potency 1 99.38 Very High Very High Very High
Antinociceptive 2 99.22 Very High Very High Very High
Enkephalin 4 97.60 Very High Very High Very High
Opioid 2 88.80 High High
narcan 1 75.32 Quite High
Morphine 3 72.84 Quite High
nociceptor 1 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors suggest that the marked antinociceptive potency of H-Tyr-D-Arg-Phe-Gly-OH and H-Tyr-D-Arg-Phe-Sar-OH is mainly due to high opioid receptor affinity.
Positive_regulation (due) of H-Tyr-D-Arg-Phe-Sar-OH Binding (affinity) of opioid receptor associated with opioid receptor, antinociceptive and potency
1) Confidence 0.01 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3612556 Disease Relevance 0 Pain Relevance 0.86

General Comments

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