INT3784

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Context Info
Confidence 0.38
First Reported 1977
Last Reported 2004
Negated 3
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.79
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hmbs) cytoplasm (Hmbs)
Anatomy Link Frequency
RVLM 1
leucocyte 1
Hmbs (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 9 100.00 Very High Very High Very High
Rostral ventrolateral medulla 8 99.52 Very High Very High Very High
Clonidine 5 99.00 Very High Very High Very High
Nicotine 9 98.44 Very High Very High Very High
abdominal pain 1 93.52 High High
nMDA receptor 3 93.20 High High
antagonist 2 92.52 High High
lidocaine 2 84.04 Quite High
local anesthetic 1 78.72 Quite High
Serotonin 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Porphyria 19 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 8 96.92 Very High Very High Very High
Disease 4 94.60 High High
Abdominal Pain 1 93.52 High High
Vomiting 1 91.28 High High
Constipation 1 80.48 Quite High
Body Weight 1 79.00 Quite High
Respiratory Failure 1 75.28 Quite High
Hereditary Coproporphyria 3 75.00 Quite High
Congenital Anomalies 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sinoaortic baroreceptor denervation (SAD) did not affect the responses to PBG and abolished only the HR response to NIC.
Neg (not) Regulation (affect) of PBG associated with porphyria and nicotine
1) Confidence 0.38 Published 1990 Journal Am. J. Physiol. Section Abstract Doc Link 2309912 Disease Relevance 1.14 Pain Relevance 0.45
In all cases (n = 6 neurons in 6 individual rats), dizocilpine inhibited the effects of CCK, PBG, and PE on RVLM presympathetic neuronal discharge.
Regulation (effects) of PBG in RVLM associated with rostral ventrolateral medulla, porphyria and cholecystokinin
2) Confidence 0.25 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15155283 Disease Relevance 0.34 Pain Relevance 1.14
No changes in the activity of ALA-S and in the hepatic and urinary porphyrin, ALA and PBG contents were observed.
Neg (No) Regulation (changes) of PBG associated with porphyria
3) Confidence 0.22 Published 1993 Journal Arzneimittelforschung Section Abstract Doc Link 8141818 Disease Relevance 0.28 Pain Relevance 0.42
The activities of the other enzymes in the pathway, leucocyte ferrochelatase and erythrocyte delta-aminolaevulinic acid dehydratase, porphobilinogen deaminase and uroporphyrinogen decarboxylase showed no consistent change.
Neg (no) Regulation (change) of porphobilinogen deaminase in leucocyte
4) Confidence 0.01 Published 1977 Journal Q. J. Med. Section Abstract Doc Link 866576 Disease Relevance 1.03 Pain Relevance 0.09

General Comments

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