INT37863

Context Info Confidence 0.61 First Reported 1983 Last Reported 2010 Negated 2 Speculated 3 Reported most in Body Documents 11 Total Number 25 Disease Relevance 3.95 Pain Relevance 4.34

cytosol (HBG2) transport (HBG2)

Anatomy Link Frequency blood 3 erythrocytes 1 HBG2 (Homo sapiens)

Pain Link Frequency Relevance Heat Paracetamol 27 100.00 local anesthetic 11 100.00 Bioavailability 2 99.90 Analgesic 21 99.72 epidural 2 99.24 anesthesia 47 98.88 tolerance 3 98.36 Pain 30 97.68 lidocaine 22 93.12 Angina 6 90.80

Disease Link Frequency Relevance Heat Nicotine Addiction 56 99.36 Syndrome 1 98.48 Ventricular Heart Septal Defects 7 97.96 Pain 31 97.68 Methemoglobinemia 138 96.44 Myocardial Infarction 2 92.72 Body Weight 17 91.92 Cv General 3 Under Development 2 90.80 Obesity 4 89.84 Heart Rate Under Development 4 89.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We studied bioavailability and changes in methemoglobin levels following topical penile exposure to 1 g of EMLA cream for 1 hour in piglets.

Regulation (changes) of methemoglobin associated with bioavailability

1) Confidence 0.61 Published 1995 Journal Biol. Neonate Section Abstract Doc Link 8835088 Disease Relevance 0.10 Pain Relevance 0.35

In the paper a thorough study of the influence of the methemoglobin levels and the occurrence of certain syndromes of clinical symptoms was made in the inhabitants living in the immediate vicinity of the large refuse dumps.

Regulation (influence) of methemoglobin associated with syndrome

2) Confidence 0.61 Published 1996 Journal Prz. Lek. Section Abstract Doc Link 8711189 Disease Relevance 0.17 Pain Relevance 0

The purpose of this study was to investigate the effect of prilocaine on serum methemoglobin levels when used as the local anesthetic in epidural anesthesia for renal transplantation, and to compare its effects with that of bupivacaine, which is the standard local anesthetic used.

Spec (investigate) Regulation (effect) of methemoglobin associated with anesthesia, epidural and local anesthetic

3) Confidence 0.60 Published 2008 Journal Middle East J Anesthesiol Section Abstract Doc Link 18637601 Disease Relevance 0 Pain Relevance 0.55

Although more than 80% of participants reported frequent use of vitamins at enrollment and during pregnancy (Table 1), vitamin use did not show a significant effect on methemoglobin levels (Tables 5 and 7).

Regulation (effect) of methemoglobin

4) Confidence 0.59 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0 Pain Relevance 0

Information about residence, primary drinking water source, water treatment devices, drinking water use patterns, smoking, use of medications that could affect methemoglobin levels such as nitrosatable drugs or anesthetics, and gastrointestinal illness within the past 24 hours was collected at each follow up.

Regulation (affect) of methemoglobin associated with nicotine addiction

5) Confidence 0.59 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0.10 Pain Relevance 0

In 3 cases methemoglobin levels were elevated by 1%, whereas in the remaining 17 cases methemoglobin values were normal.

Regulation (values) of methemoglobin

6) Confidence 0.53 Published 1987 Journal Reg Anaesth Section Abstract Doc Link 3615982 Disease Relevance 0.23 Pain Relevance 0.29

Effects of acetaminophen on methemoglobin, superoxide dismutase and Na(+)-K+ ATPase activities of human erythrocytes.

Regulation (Effects) of methemoglobin in erythrocytes associated with paracetamol

7) Confidence 0.53 Published 1995 Journal Biochem. Mol. Biol. Int. Section Title Doc Link 7627122 Disease Relevance 0 Pain Relevance 0.52

The effect of continuous infusion of intravenous nitroglycerin (NTG) on methemoglobin levels in 24 coronary care unit patients was studied.

Regulation (effect) of methemoglobin

8) Confidence 0.47 Published 1985 Journal Am. J. Cardiol. Section Abstract Doc Link 3929581 Disease Relevance 0.43 Pain Relevance 0.25

The contribution of other variables to methemoglobin variability was first explored with univariate regression by modeling individual predictor and exposure variables with baseline methemoglobin levels, and with the changes in methemoglobin over the period of gestation.

Regulation (changes) of methemoglobin

9) Confidence 0.43 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0.06 Pain Relevance 0

To evaluate the effects of sulfur dioxide and other air pollutants on methemoglobin levels during pregnancy, Mohorovic [37] measured methemoglobin levels 3 times during pregnancy at 1-month intervals in a group of women in Croatia.

Regulation (effects) of methemoglobin

10) Confidence 0.43 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0 Pain Relevance 0

Furthermore, little is known about methemoglobin levels during pregnancy and whether intake of nitrates impacts blood methemoglobin levels in pregnant women.

Regulation (known) of methemoglobin in blood

11) Confidence 0.43 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0.36 Pain Relevance 0.06

Of these, 233 (65%) used medications that could affect methemoglobin levels including those classified as "nitrosatable" drugs (i.e. a therapeutic drug that contains amides or amines).

Regulation (affect) of methemoglobin

12) Confidence 0.26 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0.31 Pain Relevance 0.17

Residual chlorine levels were not tested in the current study, therefore the potential effects of chlorination on methemoglobin levels, especially as it relates to public water systems, cannot be effectively assessed.

Regulation (effects) of methemoglobin

13) Confidence 0.26 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0 Pain Relevance 0

The objective of this study was to assess methemoglobin levels and examine how various factors affected methemoglobin levels during pregnancy.

Spec (examine) Regulation (affected) of methemoglobin

14) Confidence 0.26 Published 2010 Journal Environ Health Section Abstract Doc Link PMC2967503 Disease Relevance 0 Pain Relevance 0

We conducted a prospective investigation that incorporated individual assessment of exposure to evaluate changes in methemoglobin levels in women during pregnancy, and how various factors affected those levels, including maternal exposure to nitrates in drinking water.

Regulation (changes) of methemoglobin

15) Confidence 0.26 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0.38 Pain Relevance 0

Multi-variable regression analyses was used to evaluate the potential effects of nitrate intake from drinking water on methemoglobin levels among women who reported drinking tap water at home at the 36 weeks gestation follow up.

Regulation (effects) of methemoglobin

16) Confidence 0.26 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0.08 Pain Relevance 0

The study sought to add to the body of knowledge on methemoglobin levels and exposure to nitrates in drinking water during pregnancy by assessing methemoglobin levels (a biomarker for exposure to nitrates) in maternal blood over the period of pregnancy and evaluating the factors that could affect methemoglobin levels.

Regulation (affect) of methemoglobin in blood

17) Confidence 0.26 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0.14 Pain Relevance 0

The potential effects of vitamin rich vegetables on reducing methemoglobin level or on a woman's ability to reduce methemoglobin back to hemoglobin, is a factor also to be considered given the low levels of methemoglobin observed.

Regulation (effects) of methemoglobin

18) Confidence 0.26 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0 Pain Relevance 0

Longitudinal regression models were used to examine changes and predictors of the change in methemoglobin levels over the period of gestation.

Spec (examine) Regulation (change) of methemoglobin

19) Confidence 0.26 Published 2010 Journal Environ Health Section Abstract Doc Link PMC2967503 Disease Relevance 0 Pain Relevance 0

This trend was still evident after mean methemoglobin levels were controlled or adjusted for covariates, ?

Regulation (controlled) of methemoglobin

20) Confidence 0.23 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0 Pain Relevance 0

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