INT37865

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.27
First Reported 1987
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.13
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alad) extracellular space (Alad) lyase activity (Alad)
Anatomy Link Frequency
anterior 1
heart 1
inferior 1
Alad (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 10 97.42 Very High Very High Very High
isoflurane 3 97.20 Very High Very High Very High
alcohol 1 87.56 High High
abdominal pain 1 82.72 Quite High
fibrosis 6 77.76 Quite High
Angina 2 72.88 Quite High
ischemia 4 5.00 Very Low Very Low Very Low
Morphine 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Porphyria 5 99.12 Very High Very High Very High
Cicatrix 2 98.24 Very High Very High Very High
Coronary Heart Disease 8 97.92 Very High Very High Very High
Coronary Artery Disease 12 96.28 Very High Very High Very High
Neurologic Manifestations 1 92.80 High High
Hepatic Porphyrias 2 90.64 High High
Abdominal Pain 1 82.72 Quite High
Neuropathic Pain 3 81.56 Quite High
Disease 2 78.48 Quite High
Fibrosis 8 77.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These mice exhibit the typical biochemical characteristics of human AIP, notably, decreased hepatic Pbgd activity, increased delta-aminolevulinic acid synthase activity and massively increased urinary excretion of the heme precursor, delta-aminolevulinic acid after treatment with drugs such as phenobarbital.
Positive_regulation (increased) of delta-aminolevulinic acid synthase associated with porphyria
1) Confidence 0.27 Published 1996 Journal Nat. Genet. Section Abstract Doc Link 8563760 Disease Relevance 1.04 Pain Relevance 0.13
The effect of chronic enflurane or isoflurane anesthesia on hepatic heme regulation and the drug-metabolizing system in mice treated or not with phenobarbital (PB) was investigated. 2. delta-Aminolevulinic acid synthetase was induced 50-170% in all cases.
Positive_regulation (induced) of delta-Aminolevulinic acid synthetase associated with anesthesia and isoflurane
2) Confidence 0.24 Published 1997 Journal Gen. Pharmacol. Section Abstract Doc Link 9147027 Disease Relevance 0 Pain Relevance 0.29
All the 11 normal subjects belonged to the load-reaction group with more than 5% LV-EF increase, while the extensive anterior and inferior scar patients reacted without exception with more than 10% deficit (their basal LV-EF value was already under 45%).
Positive_regulation (increase) of LV-EF in anterior associated with cicatrix
3) Confidence 0.02 Published 1987 Journal Acta Physiol Hung Section Abstract Doc Link 3618251 Disease Relevance 0.74 Pain Relevance 0.07
With chronic LV dysfunction, LV volumes, LV mass, heart rate, and LV end diastolic pressure were increased.
Positive_regulation (increased) of With chronic LV dysfunction in heart
4) Confidence 0.01 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1654186 Disease Relevance 0.13 Pain Relevance 0.04
A systematic evaluation of contractility requires a model of LV dysfunction in which a positive inotrope is administered or a negative inotrope administered in a model with normal LV function.
Positive_regulation (requires) of model of LV dysfunction
5) Confidence 0.01 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1654186 Disease Relevance 0.47 Pain Relevance 0
All the 11 normal subjects belonged to the load-reaction group with more than 5% LV-EF increase, while the extensive anterior and inferior scar patients reacted without exception with more than 10% deficit (their basal LV-EF value was already under 45%).
Positive_regulation (increase) of LV-EF in inferior associated with cicatrix
6) Confidence 0.01 Published 1987 Journal Acta Physiol Hung Section Abstract Doc Link 3618251 Disease Relevance 0.74 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox