INT37866

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Context Info
Confidence 0.35
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 3.17
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alad) extracellular space (Alad) lyase activity (Alad)
Anatomy Link Frequency
liver 2
Alad (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 1 99.80 Very High Very High Very High
Paracetamol 16 99.38 Very High Very High Very High
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 1 99.80 Very High Very High Very High
Coronary Artery Disease 6 99.20 Very High Very High Very High
Anaemia 6 96.28 Very High Very High Very High
Hepatotoxicity 10 94.12 High High
Myocardial Infarction 1 92.36 High High
Heart Rate Under Development 2 84.08 Quite High
Toxicity 10 82.92 Quite High
Death 2 81.40 Quite High
Lead Poisoning 4 80.72 Quite High
Poisoning 6 80.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Paracetamol (1,000 mg kg(-1)) drastically depleted total glutathione levels and decreased glutathione peroxidase and delta-aminolevulinate dehydratase activity in the liver, such effects not being prevented by pretreatment with W. paludosa.
Negative_regulation (decreased) of delta-aminolevulinate dehydratase in liver associated with paracetamol
1) Confidence 0.35 Published 2006 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 16393474 Disease Relevance 0.62 Pain Relevance 0.65
Paracetamol (1,000 mg kg(-1)) drastically depleted total glutathione levels and decreased glutathione peroxidase and delta-aminolevulinate dehydratase activity in the liver, such effects not being prevented by pretreatment with W. paludosa.
Negative_regulation (depleted) of delta-aminolevulinate dehydratase in liver associated with paracetamol
2) Confidence 0.35 Published 2006 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 16393474 Disease Relevance 0.62 Pain Relevance 0.66
Farant and Wigfield[16] reported that inhibition of ALAD, a cytosolic sulfydryl enzyme and ferrochelatase by lead resulted in depressed heme synthesis that ultimately led to anemia.
Negative_regulation (inhibition) of ALAD associated with anaemia
3) Confidence 0.34 Published 2010 Journal Toxicology International Section Body Doc Link PMC2964740 Disease Relevance 0.64 Pain Relevance 0
Further, Ratcliff[17], Monterio et al.,[1819] and Hermes-lima et al.[20–22] explained that ALAD inactivation may lead to the accumulation of delta- aminoleuvulinic acid that can cause overproduction of ROS, which could lead to lead-induced oxidative damage in the cell and result in anemia.
Negative_regulation (inactivation) of ALAD associated with anaemia
4) Confidence 0.34 Published 2010 Journal Toxicology International Section Body Doc Link PMC2964740 Disease Relevance 0.64 Pain Relevance 0
In the mid seventies it could be shown by RKG-RCG, in 15 IHD patients with angina pectoris that the decrease of the basal LV-EF during ergometric load reflected the severity of IHD, compared with the increasing LV-EF tendency of 15 normal subjects.
Negative_regulation (decrease) of LV-EF associated with angina and coronary artery disease
5) Confidence 0.02 Published 1987 Journal Acta Physiol Hung Section Abstract Doc Link 3618251 Disease Relevance 0.65 Pain Relevance 0.10

General Comments

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