INT37869

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Context Info
Confidence 0.34
First Reported 1987
Last Reported 2009
Negated 2
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 3.03
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ACPP) plasma membrane (ACPP) intracellular (ACPP)
Anatomy Link Frequency
T cells 1
ACPP (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 1 97.40 Very High Very High Very High
Pain 1 80.24 Quite High
Angina 1 78.48 Quite High
Dysuria 1 68.48 Quite High
ischemia 1 63.80 Quite High
Inflammation 5 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 7 99.78 Very High Very High Very High
Prostate Or Kidney Disorder 2 99.04 Very High Very High Very High
Prostate Cancer 49 92.40 High High
Benign Prostatic Hypertrophy 115 90.56 High High
Metastasis 5 87.48 High High
Cancer 8 84.04 Quite High
Fatigue 2 82.32 Quite High
Pain 1 80.24 Quite High
Myalgia 1 80.00 Quite High
Bone Cancer 1 79.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Histologically, two types of adenocarcinoma were involved in both primary prostate and metastatic sites: one was a poorly differentiated adenocarcinoma positive for PSA and PAP but not CEA or CA19-9, and the other one was a less differentiated adenocarcinoma partially positive for CEA and CA19-9 but not for PSA or PAP.
Neg (not) Spec (partially) Regulation (positive) of PAP associated with adenocarcinoma
1) Confidence 0.34 Published 1999 Journal Urol. Int. Section Abstract Doc Link 10738193 Disease Relevance 1.14 Pain Relevance 0.08
Injections of PA2024 did not influence the reactivity of T cells against PAP and GM-CSF.
Neg (not) Regulation (influence) of PAP in T cells
2) Confidence 0.32 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10873066 Disease Relevance 0.61 Pain Relevance 0.13
Moreover, serum values of PAP and PA also decreased to the normal range.
Regulation (values) of PAP
3) Confidence 0.27 Published 1987 Journal Hinyokika Kiyo Section Abstract Doc Link 3618415 Disease Relevance 0.65 Pain Relevance 0.07
These included the up-regulated genes ACPP, CXCL5, FGFBP1, FKBP11, KLK11, PTGDS, and TIMP1.
Regulation (regulated) of ACPP
4) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 0.62 Pain Relevance 0.03

General Comments

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