INT37882

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Context Info
Confidence 0.08
First Reported 1987
Last Reported 1987
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.35
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
nucleus accumbens 1
cortex 1
Penk (Rattus norvegicus)
LOC100366054 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 20 100.00 Very High Very High Very High
Enkephalin 18 100.00 Very High Very High Very High
Nucleus accumbens 6 98.04 Very High Very High Very High
Ventral tegmentum 4 75.00 Quite High
antagonist 2 59.80 Quite High
Opioid 2 59.36 Quite High
opioid receptor 2 38.44 Quite Low
Disease Link Frequency Relevance Heat
Stress 6 98.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these data indicate that footshock stress enhances the release of enkephalin into the A10 region, and that this enkephalin activates A10 DA neurons projecting to the prefrontal cortex and nucleus accumbens.
enkephalin Positive_regulation (activates) of A10 DA in nucleus accumbens associated with stress, nucleus accumbens, dopamine and enkephalin
1) Confidence 0.08 Published 1987 Journal Brain Res. Section Abstract Doc Link 3620936 Disease Relevance 0.17 Pain Relevance 0.97
Taken together, these data indicate that footshock stress enhances the release of enkephalin into the A10 region, and that this enkephalin activates A10 DA neurons projecting to the prefrontal cortex and nucleus accumbens.
enkephalin Positive_regulation (activates) of A10 DA in cortex associated with stress, nucleus accumbens, dopamine and enkephalin
2) Confidence 0.03 Published 1987 Journal Brain Res. Section Abstract Doc Link 3620936 Disease Relevance 0.17 Pain Relevance 0.97

General Comments

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