INT37889

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Context Info
Confidence 0.65
First Reported 1987
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 75
Total Number 75
Disease Relevance 26.01
Pain Relevance 23.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry2) aging (P2ry2) plasma membrane (P2ry2)
embryo development (P2ry2) lysosome (P2ry2) signal transducer activity (P2ry2)
Anatomy Link Frequency
neurons 14
microglia 9
astrocytes 5
central nervous system 2
spinal 2
P2ry2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 473 100.00 Very High Very High Very High
Central nervous system 287 99.96 Very High Very High Very High
Sciatic nerve 23 99.96 Very High Very High Very High
Pyramidal cell 25 99.92 Very High Very High Very High
dorsal root ganglion 629 99.82 Very High Very High Very High
adenocard 433 99.64 Very High Very High Very High
Root ganglion neuron 61 99.64 Very High Very High Very High
Pain 423 99.62 Very High Very High Very High
substance P 32 99.60 Very High Very High Very High
Spinal cord 334 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anaplastic Astrocytoma 44 99.86 Very High Very High Very High
Ganglion Cysts 1061 99.82 Very High Very High Very High
Pain 473 99.62 Very High Very High Very High
Nociception 245 99.56 Very High Very High Very High
Neuropathic Pain 258 99.32 Very High Very High Very High
Brain Disease 16 99.32 Very High Very High Very High
Nervous System Injury 91 98.88 Very High Very High Very High
Proliferative Vitreoretinopathy 1 98.40 Very High Very High Very High
Apoptosis 92 97.84 Very High Very High Very High
Bordatella Infection 158 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P2Y2 R ir was expressed in a minority of SP, VIP, NPY, vesicular acetylcholine transporter, and calcitonin gene-related peptide-ir varicose fibers (5-20%) and those surrounding calbindin (5-20%) neurons.
Gene_expression (expressed) of P2Y2 in neurons associated with calcitonin gene-related peptide and substance p
1) Confidence 0.65 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 14689471 Disease Relevance 0.08 Pain Relevance 0.66
Expression of P2Y1, P2Y2, and P2Y4 protein was confirmed by western blots.
Gene_expression (Expression) of P2Y2
2) Confidence 0.65 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 14689471 Disease Relevance 0.06 Pain Relevance 0.40
The expression of P2Y R immunoreactivity (ir) in nerve cell bodies was in the order of P2Y1 R > P2Y4 R >> P2Y2 R.
Gene_expression (expression) of P2Y in nerve cell
3) Confidence 0.65 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 14689471 Disease Relevance 0.09 Pain Relevance 0.85
A metabotropic ATP receptor, P2Y(12), has been shown to be expressed in spinal microglia constitutively and be involved in chemotaxis.
Gene_expression (expressed) of P2Y in spinal
4) Confidence 0.63 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18337420 Disease Relevance 0.48 Pain Relevance 0.47
Double labeling studies revealed that cells expressing increased P2Y(12) mRNA and protein after nerve injury were exclusively microglia.
Gene_expression (expressing) of P2Y in microglia associated with nervous system injury
5) Confidence 0.63 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18337420 Disease Relevance 0.85 Pain Relevance 0.89
In situ hybridization analysis revealed widespread expression of P2Y2 mRNA in sensory neurons.
Gene_expression (expression) of P2Y2 in sensory neurons
6) Confidence 0.57 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12453048 Disease Relevance 0.07 Pain Relevance 0.26
P2Y2 mRNA was expressed in neurons of all sizes, but was seen less frequently in large cells: 90% of small cells (<30 µm diameter) were positive, as were 40% of larger cells (>40 µm diameter).
Gene_expression (expressed) of P2Y2 mRNA in neurons
7) Confidence 0.57 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 1.72 Pain Relevance 0.75
The demonstration of P2Y receptor gene expression in sensory cells and the presence of functional receptors on the cell surface suggests that these receptors can play a role in the nociceptive transmission.
Gene_expression (expression) of P2Y receptor gene associated with nociception
8) Confidence 0.57 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 0.72 Pain Relevance 0.65
Co-localization of the different P2Y receptor-subtypes with markers for nociceptive neurons showed that the P2Y1 and P2Y2 receptors are typically expressed in small, nociceptive cells, whereas the P2Y4 subtype seems to be present in large neurons involved in the transmission of tactile allodynia.
Gene_expression (expressed) of P2Y2 in neurons associated with nociception and brush evoked pain
9) Confidence 0.57 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 0.77 Pain Relevance 0.71
In situ hybridization showed that 80% of adult rat DRG neurons expressed P2Y2 mRNA, but only half of these neurons responded to UTP by phosphorylating the cAMP-responsive element binding protein (CREB) [28].
Gene_expression (expressed) of P2Y2 mRNA in neurons associated with dorsal root ganglion
10) Confidence 0.57 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 1.60 Pain Relevance 0.72
A similar distribution of P2Y2 expression was observed in neurons of the rat TG [28].
Gene_expression (expression) of P2Y2 in neurons associated with trigeminal ganglion
11) Confidence 0.57 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 1.63 Pain Relevance 0.71
However, another in situ hybridization study showed that only 20% of rat DRG neurons expressed P2Y2 receptors and that a significant population of DRG neurons co-expressed P2Y2 and TRPV1 mRNA [24].
Gene_expression (expressed) of P2Y2 in neurons associated with dorsal root ganglion
12) Confidence 0.57 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 1.45 Pain Relevance 0.64
However, further experiments are needed to reliably evaluate the expression of P2Y receptors on spinal cord dorsal horn neurons (Figure 1).
Gene_expression (expression) of P2Y in spinal cord dorsal horn associated with dorsal horn neuron and spinal cord
13) Confidence 0.57 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 0.33 Pain Relevance 0.83
Spinal cord astrocytes known to play a significant role in the modulation of pain transmission also express functional P2Y1 and P2Y2 receptors.
Gene_expression (express) of P2Y2 in astrocytes associated with pain and spinal cord
14) Confidence 0.57 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 0.79 Pain Relevance 0.76
A metabotropic ATP receptor, P2Y(12), has been shown to be expressed in spinal microglia constitutively and be involved in chemotaxis.
Gene_expression (expressed) of ATP receptor in spinal
15) Confidence 0.55 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18337420 Disease Relevance 0.48 Pain Relevance 0.47
However, with P2Y1, the fast activation was followed by a slower, but almost complete inactivation of the current in the continued presence of the agonist, an effect that has previously been observed when rat P2Y2 receptors were expressed together with GIRK1/4 in Xenopus oocytes [120].
Gene_expression (expressed) of P2Y2 in oocytes associated with agonist
16) Confidence 0.52 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0.06 Pain Relevance 0.12
Pharmacological blockade of P2Y receptors
Gene_expression (receptors) of P2Y
17) Confidence 0.48 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0.10 Pain Relevance 0.04
Our description of the P2Y receptor profile diverges from the one proposed in the above article for the presence of functional P2Y1 and P2Y14 receptors, which we did not detect in our study.
Gene_expression (profile) of P2Y receptor
18) Confidence 0.48 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0 Pain Relevance 0.03
Regulation of Na+ channels via P2Y receptors
Gene_expression (receptors) of P2Y
19) Confidence 0.45 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0.09 Pain Relevance 0.49
Regulation of ligand-gated ion channels by P2Y receptors
Gene_expression (receptors) of P2Y
20) Confidence 0.45 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0 Pain Relevance 0.21

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