INT37895

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Context Info
Confidence 0.48
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.97
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CYSLTR1) signal transducer activity (CYSLTR1)
Anatomy Link Frequency
upper 2
epithelial cells 1
A549 1
CYSLTR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 2 88.48 High High
Inflammation 38 77.92 Quite High
aspirin 91 74.88 Quite High
COX2 2 46.60 Quite Low
cINOD 9 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 168 99.96 Very High Very High Very High
Rhinitis 20 82.20 Quite High
Chronic Sinusitis 26 80.04 Quite High
INFLAMMATION 46 77.92 Quite High
Disease 25 77.12 Quite High
Hypersensitivity 16 74.80 Quite High
Paranasal Sinus Disease 1 68.12 Quite High
Nasal Polyps 27 48.80 Quite Low
Pressure And Volume Under Development 44 5.00 Very Low Very Low Very Low
Urticaria 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A functional study using two cell lines, human T lymphocytes (Jurkat) and lung epithelial cells (A549), showed enhanced promoter activity with the ht2 [T-C-G] construct compared to the ht1 [C-A-A] construct, suggesting that this polymorphism modulates CYSLTR1 expression to increase AIA susceptibility.
Positive_regulation (increase) of in A549 Gene_expression (expression) of CYSLTR1 in epithelial cells associated with asthma
1) Confidence 0.48 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687575 Disease Relevance 0.66 Pain Relevance 0.03
These results indicate that the bronchoconstriction produced by aerosolized LTD4 in normal subjects is not mediated by cyclooxygenase products of arachidonic acid metabolism or irritant receptors in the upper airways.
Neg (not) Positive_regulation (mediated) of Gene_expression (produced) of LTD4 in upper
2) Confidence 0.40 Published 1987 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 3624684 Disease Relevance 0 Pain Relevance 0.15
CysLT1 mRNA expression was significantly increased in CRS-NP compared to CRS and controls, and CRS compared to controls, whereas CysLT2 mRNA was enhanced in both CRS groups without differences between them.
Positive_regulation (increased) of Gene_expression (expression) of CysLT1 mRNA
3) Confidence 0.31 Published 2006 Journal Respir Res Section Abstract Doc Link PMC1481584 Disease Relevance 1.02 Pain Relevance 0.11
Several SNPs in the promoter of LTC4S [19], [45] and ALOX5 [20] that encode key enzymes for CysLT synthesis also showed significant associations with AIA [13], [46].
Positive_regulation (enzymes) of Gene_expression (synthesis) of CysLT associated with asthma
4) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972220 Disease Relevance 1.30 Pain Relevance 0.15

General Comments

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