INT37896

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Context Info
Confidence 0.67
First Reported 1987
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 37
Total Number 37
Disease Relevance 17.28
Pain Relevance 9.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGS1) small molecule metabolic process (PTGS1) aging (PTGS1)
Golgi apparatus (PTGS1) endoplasmic reticulum (PTGS1) lipid metabolic process (PTGS1)
Anatomy Link Frequency
colon 6
PGE2 4
THP-1 4
body 4
margin 2
PTGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 33 100.00 Very High Very High Very High
COX2 33 100.00 Very High Very High Very High
cOX1 15 100.00 Very High Very High Very High
Perioperative pain 3 100.00 Very High Very High Very High
Serotonin 2 100.00 Very High Very High Very High
cytokine 56 99.92 Very High Very High Very High
Inflammatory response 6 99.92 Very High Very High Very High
Paracetamol 7 99.86 Very High Very High Very High
Inflammation 81 99.68 Very High Very High Very High
COX-2 inhibitor 19 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Phosphate Metabolism Disorders 55 100.00 Very High Very High Very High
Colon Cancer 28 100.00 Very High Very High Very High
Post Operative Pain 2 100.00 Very High Very High Very High
Cancer 35 99.98 Very High Very High Very High
Stomach Cancer 5 99.98 Very High Very High Very High
INFLAMMATION 115 99.74 Very High Very High Very High
Polyps 1 99.26 Very High Very High Very High
Adenoma 5 99.16 Very High Very High Very High
Pox Virus Infection 4 99.00 Very High Very High Very High
Targeted Disruption 3 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of human PGHS-1 and PGHS-2 in the human colon carcinoma cells increased the DNA synthesis rate as compared with mock-transfected cells which did not express any isoforms.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of PGHS-1 in colon associated with colon cancer
1) Confidence 0.67 Published 2009 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 19457650 Disease Relevance 0.33 Pain Relevance 0.25
Overexpression of PGHS1 strongly potentiated NF-kappa B activation by phorbol esters and dramatically elevated the generation of intracellular reactive oxygen species (ROS) in response to low concentrations of t-butyl peroxide.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of PGHS1
2) Confidence 0.57 Published 1995 Journal J. Inflamm. Section Abstract Doc Link 8867670 Disease Relevance 0.17 Pain Relevance 0.29
Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of prostaglandin G/H synthase associated with aspirin, inflammation, pox virus infection and cinod
3) Confidence 0.49 Published 1994 Journal Mol. Pharmacol. Section Title Doc Link 8114674 Disease Relevance 0.44 Pain Relevance 0.15
Cyclooxygenase-2 (COX-2), an inducible prostaglandin G/H synthase, is overexpressed in pre-neoplastic tissues and several human cancers including colorectal cancer.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of prostaglandin G/H synthase associated with cancer and colon cancer
4) Confidence 0.49 Published 2004 Journal Front. Biosci. Section Abstract Doc Link 15353307 Disease Relevance 0.48 Pain Relevance 0.09
Each drug produced a concentration-dependent activation of the PPAR isoforms and fatty acid beta-oxidase activity, inhibition of human arachidonic acid-induced platelet aggregation and serotonin secretion, and inhibition of PGHS-1 and PGHS-2 activities.
Positive_regulation (activation) of Gene_expression (produced) of PGHS-1 in platelet associated with serotonin
5) Confidence 0.41 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11755111 Disease Relevance 0.08 Pain Relevance 0.20
It is present in two isoforms: COX-1 (constitutive cyclooxygenase) which is produced in the body to maintain normal haemostatic functions, and COX-2 (inducible cyclooxygenase), which is induced during inflammation in response to cytokines.
Positive_regulation (induced) of Gene_expression (produced) of cyclooxygenase in body associated with inflammation and cytokine
6) Confidence 0.37 Published 2001 Journal J. Pathol. Section Abstract Doc Link 11745699 Disease Relevance 0.74 Pain Relevance 0.19
G1 delay in cells overexpressing prostaglandin endoperoxide synthase-2.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of endoperoxide synthase associated with aspirin
7) Confidence 0.32 Published 1996 Journal Cancer Res. Section Title Doc Link 8631005 Disease Relevance 1.14 Pain Relevance 0.45
Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas.
Positive_regulation (regulation) of Gene_expression (expression) of cyclooxygenase associated with adenocarcinoma, adenoma and cox2
8) Confidence 0.28 Published 1994 Journal Gastroenterology Section Title Doc Link 7926468 Disease Relevance 0.38 Pain Relevance 0.33
In particular, the inducible form of cyclooxygenase (COX), the rate-limiting enzyme in prostaglandin biosynthesis, is overexpressed in colon tumors.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of cyclooxygenase in colon associated with colon cancer
9) Confidence 0.27 Published 1998 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 9521170 Disease Relevance 0.88 Pain Relevance 0.39
It is present in two isoforms: COX-1 (constitutive cyclooxygenase) which is produced in the body to maintain normal haemostatic functions, and COX-2 (inducible cyclooxygenase), which is induced during inflammation in response to cytokines.
Positive_regulation (induced) of Gene_expression (produced) of cyclooxygenase in body associated with inflammation and cytokine
10) Confidence 0.27 Published 2001 Journal J. Pathol. Section Abstract Doc Link 11745699 Disease Relevance 0.73 Pain Relevance 0.19
Increased expression of cyclooxygenase (COX) and overproduction of prostaglandins (PGs) have been implicated in the development and progression of colorectal cancer (CRC).
Positive_regulation (Increased) of Gene_expression (expression) of cyclooxygenase associated with colon cancer
11) Confidence 0.23 Published 1998 Journal Cancer Res. Section Abstract Doc Link 9622066 Disease Relevance 0.42 Pain Relevance 0
In the present study, we describe the proinflammatory effects of bupivacaine on local prostaglandin E2 (PGE2) production and cyclooxygenase (COX) gene expression that increases postoperative pain in human subjects.
Positive_regulation (increases) of Gene_expression (expression) of cyclooxygenase in PGE2 associated with perioperative pain
12) Confidence 0.21 Published 2008 Journal Anesth. Analg. Section Abstract Doc Link 18165598 Disease Relevance 0.44 Pain Relevance 0.47
Prostaglandins are generated through two isoforms of the enzyme cyclooxygenase, the constitutively expressed cyclooxygenase (Cox)-1 and Cox-2, which is induced at sites of inflammation.
Positive_regulation (induced) of Gene_expression (expressed) of cyclooxygenase associated with inflammation
13) Confidence 0.20 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9808683 Disease Relevance 0.22 Pain Relevance 0.13
Prostaglandins are generated through two isoforms of the enzyme cyclooxygenase, the constitutively expressed cyclooxygenase (Cox)-1 and Cox-2, which is induced at sites of inflammation.
Positive_regulation (generated) of Gene_expression (expressed) of cyclooxygenase associated with inflammation
14) Confidence 0.20 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9808683 Disease Relevance 0.16 Pain Relevance 0.08
Prostaglandins are generated through two isoforms of the enzyme cyclooxygenase, the constitutively expressed cyclooxygenase (Cox)-1 and Cox-2, which is induced at sites of inflammation.
Positive_regulation (induced) of Gene_expression (expressed) of cyclooxygenase associated with inflammation
15) Confidence 0.20 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9808683 Disease Relevance 0.22 Pain Relevance 0.13
Prostaglandins are generated through two isoforms of the enzyme cyclooxygenase, the constitutively expressed cyclooxygenase (Cox)-1 and Cox-2, which is induced at sites of inflammation.
Positive_regulation (generated) of Gene_expression (expressed) of cyclooxygenase associated with inflammation
16) Confidence 0.20 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9808683 Disease Relevance 0.22 Pain Relevance 0.13
For cells pretreated with flurbiprofen or meclofenamate, hPGHS-2 activities, but not hPGHS-1 activities, were recovered relatively rapidly; with indomethacin, recoveries of hPGHS-1 and hPGHS-2 activities were both slow. hPGHS-2 is thought to be the target of NSAIDs acting as anti-inflammatory agents.
Positive_regulation (recoveries) of Gene_expression (recoveries) of hPGHS-1 associated with inflammation and cinod
17) Confidence 0.18 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7965814 Disease Relevance 0.23 Pain Relevance 0.92
Expression of cyclooxygenase 1 and cyclooxygenase 2 in human synovial tissue: differential elevation of cyclooxygenase 2 in inflammatory joint diseases.
Positive_regulation (elevation) of Gene_expression (Expression) of cyclooxygenase in joint associated with inflammation, cox2, arthropathy and cox1
18) Confidence 0.17 Published 1998 Journal Arthritis Rheum. Section Title Doc Link 9433877 Disease Relevance 0.20 Pain Relevance 0.62
Since up to 50% of polyps and 85% of colonic tumors in humans overexpress cyclooxygenase (COX-2), COX-2 inhibitors are an ideal drug candidate for CRC prevention or treatment.
Positive_regulation (overexpress) of Gene_expression (overexpress) of cyclooxygenase associated with cancer, colon cancer, polyps and cox-2 inhibitor
19) Confidence 0.17 Published 2005 Journal Oncology Section Abstract Doc Link 16210875 Disease Relevance 1.19 Pain Relevance 0.49
These results indicate that the bronchoconstriction produced by aerosolized LTD4 in normal subjects is not mediated by cyclooxygenase products of arachidonic acid metabolism or irritant receptors in the upper airways.
Neg (not) Positive_regulation (mediated) of Gene_expression (products) of cyclooxygenase in upper
20) Confidence 0.17 Published 1987 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 3624684 Disease Relevance 0 Pain Relevance 0.14

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