INT37899

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Context Info
Confidence 0.58
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 0.53
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Calm2) nucleoplasm (Calm2) cytoskeleton (Calm2)
cell cycle (Calm2) cellular_component (Calm2) biological_process (Calm2)
Anatomy Link Frequency
row 1
testis 1
striatum 1
Calm2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 12 99.24 Very High Very High Very High
antagonist 9 98.92 Very High Very High Very High
nMDA receptor 4 98.12 Very High Very High Very High
narcan 3 92.08 High High
Hippocampus 17 87.80 High High
Spinal cord 2 87.28 High High
agonist 3 85.40 High High
opiate 4 85.08 High High
Opioid 4 81.84 Quite High
addiction 40 78.56 Quite High
Disease Link Frequency Relevance Heat
Epilepsy 16 95.60 Very High Very High Very High
Status Epilepticus 57 84.52 Quite High
Schizophrenia 3 83.36 Quite High
Apoptosis 10 50.00 Quite Low
Syndrome 4 46.48 Quite Low
Convulsion 18 39.16 Quite Low
Ganglion Cysts 28 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Channelopathies 8 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specific CCK-B receptor antagonist L365, 260 could partially block the effects of CCK-8 increased CaM activity at 1 mumol/L.
Positive_regulation (increased) of CaM associated with antagonist
1) Confidence 0.58 Published 1994 Journal Sheng Li Xue Bao Section Abstract Doc Link 7973792 Disease Relevance 0 Pain Relevance 0.44
In contrast, CCK-8 (10-100 nmol/L) induced a significant increase in CaM activity (P < 0.05-0.01), and was capable of antagonizing the suppressive effect induced by NDAP.
Positive_regulation (increase) of CaM
2) Confidence 0.58 Published 1994 Journal Sheng Li Xue Bao Section Abstract Doc Link 7973792 Disease Relevance 0 Pain Relevance 0.45
The results demonstrate that the requirement for Ca2+/CaM to observe Gpp(NH)p-mediated inhibition depends on the basal activity of adenylate cyclase, whereas hormone-mediated inhibition is Ca2+/CaM independent under all conditions.
Positive_regulation (requirement) of CaM
3) Confidence 0.40 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 3625205 Disease Relevance 0 Pain Relevance 0.41
Mg2+ dose-response curves also reinforced the differences in the Ca2+/CaM requirement for Gpp(NH)p- and morphine-induced inhibition.
Positive_regulation (requirement) of CaM associated with morphine
4) Confidence 0.40 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 3625205 Disease Relevance 0 Pain Relevance 0.52
Results indicated that repeated treatment with haloperidol, clozapine or risperidone increased CaM protein and CaMII mRNA levels but decreased calmodulin-dependent protein kinase IIalpha (CaMKIIalpha) IV (CaMKIV), kinase alpha (CaMKKalpha), kinase beta (CaMKKbeta) and calcineurin protein levels in the striatum of Sprague-Dawley rats (Rattus Norvegicus).
Positive_regulation (increased) of CaM in striatum
5) Confidence 0.33 Published 2009 Journal Neuroscience Section Abstract Doc Link 19289156 Disease Relevance 0.16 Pain Relevance 0.06
But L-NNA could significantly inhibit the abstinent syndrome, decrease NOS positive cells and apoptosis, and increase CaM content and the activity of SOD and GSHPx in the testis.
Positive_regulation (increase) of CaM in testis
6) Confidence 0.32 Published 2004 Journal Zhonghua Nan Ke Xue Section Body Doc Link 15595686 Disease Relevance 0 Pain Relevance 0
Furthermore, the increased NR2C subunit expression in our model may also be associated with the induction of CaM kinase II isoforms, which are involved in the NMDA receptor-mediated Ca2+ signalling in an in vitro model of epilepsy [92].
Positive_regulation (induction) of CaM associated with epilepsy and nmda receptor
7) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.37 Pain Relevance 0.26
First, just as voltage depolarization can enhance opening of the S6 activation gate (Fig. 4 D, springs), CaM-driven conformational changes act to suppress opening of the very same cytoplasmic gate (red arrows in bottom row).
Positive_regulation (enhance) of CaM in row
8) Confidence 0.09 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0 Pain Relevance 0
Thus, pulsatile Ca2+ entry will be converted to brief, pulse-like surges of Ca2+/CaM, with the same temporal pattern as the channel openings (Fig. 8 B, middle).
Positive_regulation (surges) of CaM
9) Confidence 0.06 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592819 Disease Relevance 0 Pain Relevance 0.06
Further, because decreasing Ca2+ flux through open channels has little effect on Ca2+/CaM elevations, local CaMKII activation is largely dictated by the frequency of channel openings and not the magnitude of the open channel Ca2+ flux, thus accounting for the dichotomous dependences of pCaMKII on Po and iCa (Fig. 5 D).
Neg (little) Positive_regulation (elevations) of CaM
10) Confidence 0.06 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592819 Disease Relevance 0 Pain Relevance 0.07

General Comments

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