INT37900

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Context Info
Confidence 0.36
First Reported 1987
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 0.52
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Calm2) nucleoplasm (Calm2) cytoskeleton (Calm2)
cell cycle (Calm2) cellular_component (Calm2) biological_process (Calm2)
Anatomy Link Frequency
pituitary 1
brains 1
Calm2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 15 99.08 Very High Very High Very High
narcan 3 89.92 High High
agonist 39 85.28 High High
Dopamine 46 84.92 Quite High
opiate 3 75.00 Quite High
Neurotransmitter 8 74.44 Quite High
addiction 35 73.88 Quite High
dopamine receptor 2 43.92 Quite Low
antagonist 6 42.48 Quite Low
fluoxetine 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Schizophrenia 8 98.32 Very High Very High Very High
Syndrome 12 80.20 Quite High
Channelopathies 24 78.80 Quite High
Shock 13 10.28 Low Low
Repression 1 9.92 Low Low
Disease 17 5.00 Very Low Very Low Very Low
Ganglion Cysts 14 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Autism 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results demonstrate that the requirement for Ca2+/CaM to observe Gpp(NH)p-mediated inhibition depends on the basal activity of adenylate cyclase, whereas hormone-mediated inhibition is Ca2+/CaM independent under all conditions.
Neg (independent) Regulation (independent) of CaM
1) Confidence 0.36 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 3625205 Disease Relevance 0 Pain Relevance 0.33
Gpp(NH)p-mediated inhibition was dependent on the presence of Ca2+/CaM at 24 degrees C; the inhibition was independent of Ca2+/CaM at 18 degrees C; and inhibition could not be detected in the presence, or absence, of Ca2+/CaM at 30 degrees C.
Neg (independent) Regulation (independent) of CaM
2) Confidence 0.36 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 3625205 Disease Relevance 0 Pain Relevance 0.45
Under these conditions, both Gpp(NH)p- and morphine-induced inhibition of adenylate cyclase were independent of Ca2+/CaM.
Neg (independent) Regulation (independent) of CaM associated with morphine
3) Confidence 0.32 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 3625205 Disease Relevance 0 Pain Relevance 0.42
Calcineurin is a calmodulin (CaM) dependent protein phosphatase recently found to be altered in the brains of patients suffering from schizophrenia and by repeated antipsychotic treatment in rats.
Regulation (altered) of CaM in brains associated with schizophrenia
4) Confidence 0.13 Published 2009 Journal Neuroscience Section Abstract Doc Link 19289156 Disease Relevance 0.19 Pain Relevance 0
In the current study, the effects of selected psychoactive drugs were investigated using Western blotting, in situ hybridization and immunocytochemistry to determine if they target CaM, calmodulin-dependent protein kinases (CaMK) or calcineurin.
Regulation (target) of CaM
5) Confidence 0.13 Published 2009 Journal Neuroscience Section Abstract Doc Link 19289156 Disease Relevance 0.17 Pain Relevance 0
The past decade has witnessed many discoveries about the early events underlying Ca2+/CaM modulation of the family of Ca2+ channels.
Regulation (modulation) of CaM
6) Confidence 0.11 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0.08 Pain Relevance 0
To distinguish among these potential downstream effects of CDI, this paper develops theoretical analyses that make a discriminating prediction regarding Ca2+/CaM-mediated Ca2+ channel regulation: mutations in the distal S6 transmembrane regions (the intracellular activation gate) should produce distinctive effects on activation and inactivation, depending on which mechanism holds true.
Spec (analyses) Regulation (regulation) of CaM
7) Confidence 0.11 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0.08 Pain Relevance 0
Further, because decreasing Ca2+ flux through open channels has little effect on Ca2+/CaM elevations, local CaMKII activation is largely dictated by the frequency of channel openings and not the magnitude of the open channel Ca2+ flux, thus accounting for the dichotomous dependences of pCaMKII on Po and iCa (Fig. 5 D).
Neg (little) Regulation (effect) of CaM
8) Confidence 0.06 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592819 Disease Relevance 0 Pain Relevance 0.07
Finally, our new results about the end-stage effects of CDI, together with rapid advances concerning the early events underlying Ca2+/CaM modulation of CaV1/2 channels, set the stage for investigating the events that link these two realms.
Regulation (modulation) of CaM
9) Confidence 0.05 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0 Pain Relevance 0
Together the data indicate CaM is under the regulation of the D2 receptor in the goldfish hypothalamo-pituitary system.
Regulation (regulation) of CaM in pituitary
10) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924890 Disease Relevance 0 Pain Relevance 0.12

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