INT37907

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Context Info
Confidence 0.41
First Reported 1987
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.55
Pain Relevance 4.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Capns1) cytoplasm (Capns1)
Anatomy Link Frequency
vasculature 1
Capns1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endep 30 99.84 Very High Very High Very High
c fibre 6 99.84 Very High Very High Very High
fluoxetine 18 96.56 Very High Very High Very High
tetrodotoxin 12 90.96 High High
Action potential 1 86.80 High High
corticosteroid 38 78.04 Quite High
sodium channel 2 73.28 Quite High
Pain scale 9 73.04 Quite High
anesthesia 2 65.04 Quite High
Nortriptyline 2 63.76 Quite High
Disease Link Frequency Relevance Heat
Syndrome 189 100.00 Very High Very High Very High
Chronic Sinusitis 93 99.74 Very High Very High Very High
Diabetes Mellitus 41 99.68 Very High Very High Very High
Disease 41 98.08 Very High Very High Very High
Sinusitis 48 97.10 Very High Very High Very High
Diabetic Angiopathy 2 92.04 High High
Insulin Resistance 5 90.68 High High
Pressure And Volume Under Development 30 87.72 High High
Nicotine Addiction 3 83.12 Quite High
Recurrence 10 80.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Perfusions of two different concentrations of dantrolene sodium in the same rat showed that an increase of the perfusate concentration results in a proportional increase in the Css.
Positive_regulation (increase) of Css
1) Confidence 0.41 Published 1987 Journal J Pharm Sci Section Abstract Doc Link 3625485 Disease Relevance 0.07 Pain Relevance 0.07
In contrast, CDPs elicited by C-fibre stimulation persisted with longer latency and reduced amplitude in the first part of the CDP.
Positive_regulation (elicited) of CDPs associated with c fibre
2) Confidence 0.36 Published 2001 Journal Neurosci. Res. Section Abstract Doc Link 11274740 Disease Relevance 0 Pain Relevance 1.34
The test-retest reliability in the present study was substantial for all CSS and SF-36 scales, as previously reported for the CSS [5,18] and higher than reported for some other disease-specific instruments [6,29].
Positive_regulation (reported) of CSS associated with disease
3) Confidence 0.35 Published 2006 Journal BMC Ear Nose Throat Disord Section Body Doc Link PMC1468424 Disease Relevance 0.28 Pain Relevance 0.07
Completers, who responded to the sinusitis symptoms scale of the CSS at baseline and after 12 weeks (n = 47), tended to be somewhat older, had suffered from chronic sinusitis longer, and had better baseline CSS and SF-36 scores on all subscales than dropouts (n = 18) after 12 weeks, although only the differences on the General health (p = 0.03) and the Social functioning scales (p = 0.04) of the SF-36 were statistically significant.
Positive_regulation (baseline) of CSS associated with chronic sinusitis and sinusitis
4) Confidence 0.35 Published 2006 Journal BMC Ear Nose Throat Disord Section Body Doc Link PMC1468424 Disease Relevance 0.54 Pain Relevance 0
Completers, who responded to the sinusitis symptoms scale of the CSS at baseline and after 12 weeks (n = 47), tended to be somewhat older, had suffered from chronic sinusitis longer, and had better baseline CSS and SF-36 scores on all subscales than dropouts (n = 18) after 12 weeks, although only the differences on the General health (p = 0.03) and the Social functioning scales (p = 0.04) of the SF-36 were statistically significant.
Positive_regulation (had) of CSS associated with chronic sinusitis and sinusitis
5) Confidence 0.35 Published 2006 Journal BMC Ear Nose Throat Disord Section Body Doc Link PMC1468424 Disease Relevance 0.54 Pain Relevance 0
The calcium-dependent protease ยต-calpain is increased in the diabetic vasculature and that inhibition of calpain activity attenuates the vascular dysfunction associated with chronic diabetes, which indicated a role of calpain in the pathophysiology of diabetic vascular disease 32.
Positive_regulation (increased) of calcium-dependent protease in vasculature associated with diabetic angiopathy and diabetes mellitus
6) Confidence 0.06 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2536707 Disease Relevance 0.73 Pain Relevance 0
The twofold increase in Css of AMI and ninefold increase in Css of NTRIP seem to be the result of inhibition of the metabolism of these compounds by FLU, particularly the ring hydroxylation.
Positive_regulation (increase) of Css associated with endep and fluoxetine
7) Confidence 0.01 Published 1995 Journal J Clin Pharmacol Section Abstract Doc Link 7751409 Disease Relevance 0 Pain Relevance 1.25
The twofold increase in Css of AMI and ninefold increase in Css of NTRIP seem to be the result of inhibition of the metabolism of these compounds by FLU, particularly the ring hydroxylation.
Positive_regulation (increase) of Css associated with endep and fluoxetine
8) Confidence 0.01 Published 1995 Journal J Clin Pharmacol Section Abstract Doc Link 7751409 Disease Relevance 0 Pain Relevance 1.24
Eight (15%) patients had at least 3 of the ACR criteria for classifying CSS before LTRA treatment, and therefore may have had formes frustes CSS, and the CSS symptoms increased in all 8 patients while on LTRA therapy.
Positive_regulation (increased) of CSS associated with syndrome
9) Confidence 0.01 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661620 Disease Relevance 1.39 Pain Relevance 0.13

General Comments

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