INT37912

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Context Info
Confidence 0.26
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 5.84
Pain Relevance 4.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Chd7) helicase activity (Chd7) DNA binding (Chd7)
Anatomy Link Frequency
livers 1
brain 1
Chd7 (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 26 100.00 Very High Very High Very High
Dopamine 16 99.84 Very High Very High Very High
Morphine 21 99.34 Very High Very High Very High
Inflammation 49 99.28 Very High Very High Very High
noradrenaline 6 99.12 Very High Very High Very High
withdrawal 4 99.02 Very High Very High Very High
Paracetamol 14 98.56 Very High Very High Very High
Eae 1 95.96 Very High Very High Very High
endometriosis 9 91.76 High High
Hyperalgesia 1 85.44 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 48 99.28 Very High Very High Very High
Organ Transplantation 8 99.04 Very High Very High Very High
Autoimmune Disease 24 97.76 Very High Very High Very High
Hepatotoxicity 6 97.68 Very High Very High Very High
Hypersensitivity 13 96.88 Very High Very High Very High
Peritonitis 3 94.84 High High
Colitis 3 94.32 High High
Staphylococcus Infection 1 93.96 High High
Burns 1 93.48 High High
Endometriosis 10 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of morphine withdrawal and challenge on the alpha-methyl-rho-tyrosine (alpha MT)-induced depletion of dopamine (DA) as well as on DA metabolism and 3H-SCH 23390 and 3H-spiperone binding were studied in the striata of male mice.
Negative_regulation (depletion) of alpha MT associated with dopamine, withdrawal and morphine
1) Confidence 0.26 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7870194 Disease Relevance 0 Pain Relevance 0.91
The effect of morphine on the alpha-methyl-p-tyrosine (alpha MT)-induced depletion of dopamine (DA) and noradrenaline (NA) was studied in various brain areas of male NMRI mice, whose locomotor activity is clearly stimulated by morphine.
Negative_regulation (depletion) of alpha MT in brain associated with dopamine, eae, noradrenaline and morphine
2) Confidence 0.18 Published 1987 Journal Pharmacol. Toxicol. Section Abstract Doc Link 3628178 Disease Relevance 0 Pain Relevance 1.00
In summary, this study demonstrated that MT deficiency renders animals more vulnerable to acetaminophen-induced hepatotoxicity.
Negative_regulation (deficiency) of MT associated with paracetamol and hepatotoxicity
3) Confidence 0.13 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087053 Disease Relevance 0.45 Pain Relevance 0.84
Treatment of TX mice with TTM significantly reduced elevated hepatic copper and MT.
Negative_regulation (reduced) of MT
4) Confidence 0.11 Published 2002 Journal J. Inorg. Biochem. Section Abstract Doc Link 11803042 Disease Relevance 0.40 Pain Relevance 0.07
Nodules appeared spontaneously in TX mouse livers at 8-12 months that maintained high copper levels, but with more normal morphology and decreased MT levels.
Negative_regulation (decreased) of MT in livers
5) Confidence 0.11 Published 2002 Journal J. Inorg. Biochem. Section Abstract Doc Link 11803042 Disease Relevance 0.42 Pain Relevance 0.07
The present data clearly showed the effectiveness of acid suppressants, especially PPI, for suppressing LDA-induced mucosal damage, which is consistent with previous data [6].
Negative_regulation (suppressing) of LDA associated with aspirin
6) Confidence 0.05 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901760 Disease Relevance 0.55 Pain Relevance 0.35
Diagnostic accuracy was calculated using ST ICT and MT IBT results compared with the gold standard reference IFA assay results for each patient sample.
Negative_regulation (using) of MT IBT
7) Confidence 0.02 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2911186 Disease Relevance 0.38 Pain Relevance 0
JANEX-1/WHI-P131 is a rationally designed novel JAK3 inhibitor with potent anti-inflammatory activity in several cellular and in vivo animal models of inflammation, including mouse models of peritonitis, colitis, cellulitis, sunburn, and airway inflammation with favorable toxicity and pharmacokinetic profile.
Negative_regulation (inhibitor) of WHI-P131 associated with staphylococcus infection, colitis, toxicity, inflammation, burns and peritonitis
8) Confidence 0.02 Published 2007 Journal Am. J. Reprod. Immunol. Section Abstract Doc Link 17631002 Disease Relevance 2.28 Pain Relevance 0.89
A number of JAK3 inhibitors, such as WHI-P131, WHI-P154, and PNU156804, which are not highly selective against other members of the JAK family of kinases, have been reported and included in a review article [48].
Negative_regulation (inhibitors) of WHI-P131
9) Confidence 0.01 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.66 Pain Relevance 0.15
A number of JAK3 inhibitors, such as WHI-P131, WHI-P154, and PNU156804, which are not highly selective against other members of the JAK family of kinases, have been reported and included in a review article [48].
Negative_regulation (inhibitors) of WHI-P154
10) Confidence 0.01 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.71 Pain Relevance 0.17

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