INT37949

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Context Info
Confidence 0.42
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.05
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CTSC) aging (CTSC) Golgi apparatus (CTSC)
endoplasmic reticulum (CTSC) lysosome (CTSC)
Anatomy Link Frequency
spleen 1
CTSC (Homo sapiens)
Pain Link Frequency Relevance Heat
spastic colon 1 94.72 High High
depression 35 50.00 Quite Low
abdominal pain 1 32.16 Quite Low
cytokine 17 5.00 Very Low Very Low Very Low
chemokine 13 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
long-term potentiation 4 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Splenomegaly 12 100.00 Very High Very High Very High
Malaria 2 95.92 Very High Very High Very High
Spasticity 1 94.72 High High
Hemolytic Anemia 1 83.16 Quite High
Major Depressive Disorder 25 77.44 Quite High
Schizophrenia 50 57.20 Quite High
Disease 31 54.48 Quite High
Depression 38 50.00 Quite Low
Abdominal Pain 1 32.16 Quite Low
INFLAMMATION 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No significant stimulation of HMS was observed.
Neg (No) Positive_regulation (stimulation) of HMS
1) Confidence 0.42 Published 1987 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 3654034 Disease Relevance 0.18 Pain Relevance 0.09
Hyper-reactive Malarial Splenomegaly (HMS) is massive enlargement of the spleen resulting from abnormal immune response to repeated attacks of malaria.
Positive_regulation (Hyper-reactive) of HMS in spleen associated with malaria and splenomegaly
2) Confidence 0.16 Published 2008 Journal Acta Trop. Section Abstract Doc Link 18023424 Disease Relevance 0.68 Pain Relevance 0
The discriminative model generated by RF and the corresponding ROC curves (Figure S4, Supporting Information) basically confirm the findings obtained by more traditional multivariate PCA and PLS analysis.
Positive_regulation (multivariate) of PLS
3) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820097 Disease Relevance 0.19 Pain Relevance 0

General Comments

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