INT3795

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Context Info
Confidence 0.68
First Reported 1977
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 46
Total Number 47
Disease Relevance 22.43
Pain Relevance 6.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ighm)
Anatomy Link Frequency
B cells 3
blood 2
plasma 1
plasma cells 1
erythrocyte 1
Ighm (Mus musculus)
Pain Link Frequency Relevance Heat
diclofenac 48 99.54 Very High Very High Very High
qutenza 15 99.20 Very High Very High Very High
Acupuncture 57 98.84 Very High Very High Very High
depression 4 98.64 Very High Very High Very High
Arthritis 69 97.92 Very High Very High Very High
chemokine 24 97.60 Very High Very High Very High
Neuritis 25 94.00 High High
cytokine 171 93.24 High High
Dysuria 1 93.04 High High
Inflammation 171 91.12 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 204 99.98 Very High Very High Very High
Immunization 93 99.76 Very High Very High Very High
Infection 499 99.64 Very High Very High Very High
Rheumatoid Arthritis 234 99.52 Very High Very High Very High
Cv Unclassified Under Development 17 99.48 Very High Very High Very High
Autoimmune Disease 54 99.08 Very High Very High Very High
Increased Venous Pressure Under Development 6 99.08 Very High Very High Very High
Depression 4 98.64 Very High Very High Very High
Neuromyelitis Optica 215 98.40 Very High Very High Very High
Intervertebral Disk Displacement 9 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other manifestations included neurologic abnormalties, myocardial conduction abnormalities, serum cryoprecipitates, elevated serum IgM levels, and elevated erythrocyte sedimentation rates.
Positive_regulation (elevated) of IgM in erythrocyte associated with cv unclassified under development
1) Confidence 0.68 Published 1977 Journal Ann. Intern. Med. Section Abstract Doc Link 869348 Disease Relevance 1.38 Pain Relevance 0.35
The Weil-Felix-reaction revealed a high antibody titre against OX 19, the IFT for Rickettsia typhi a significant increase of IgM with seroconversion for IgG.
Positive_regulation (increase) of IgM
2) Confidence 0.68 Published 2001 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 11450623 Disease Relevance 0.25 Pain Relevance 0
In addition, the number of antibody-producing B cells and serum IgG and IgM levels increased in mice fed 20 ppm CAP as compared to the control with no CAP.
Positive_regulation (increased) of IgM in B cells associated with qutenza
3) Confidence 0.44 Published 1998 Journal Int J Vitam Nutr Res Section Abstract Doc Link 9565827 Disease Relevance 0.18 Pain Relevance 1.05
Likewise, diclofenac caused dose-dependent increases (0.25-1.00 mg) in PLN cellularity and IgM AFCs.
Positive_regulation (increases) of IgM associated with diclofenac
4) Confidence 0.44 Published 2002 Journal Toxicol. Lett. Section Abstract Doc Link 11992736 Disease Relevance 0 Pain Relevance 0.38
When co-injected with the reporter antigen TNP-Ficoll (trinitrophenyl Ficoll), 0.50 mg diclofenac caused significant increases in PLN weight, PLN cellularity, and induced IgM and IgG(1) anti-TNP antibody forming cells (AFCs) in the PLN.
Positive_regulation (induced) of IgM associated with diclofenac
5) Confidence 0.44 Published 2002 Journal Toxicol. Lett. Section Abstract Doc Link 11992736 Disease Relevance 0.37 Pain Relevance 0.55
Sensitivity and specificity for the MT IBT determined by using the criteria of a four-fold increase in IgM against Rickettsia typhi between paired serum samples were 61.2% (95% CI = 53.7–68.3%) and 86.5% (95% CI = 84.1–88.8%), respectively.
Positive_regulation (increase) of IgM
6) Confidence 0.43 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Abstract Doc Link PMC2911186 Disease Relevance 0.45 Pain Relevance 0
There was a significant association between ST ICT and MT IBT positivity rates and increasing IFA IgM titers (ST ICT and MT IBT Pearson's ?
Positive_regulation (increasing) of IgM
7) Confidence 0.43 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2911186 Disease Relevance 0 Pain Relevance 0
Sensitivity and specificity for the ST ICT determined by using the diagnostic criteria of a four-fold increase in IgM against Orientia tsutsugamushi between paired samples were 23.8% (95% confidence interval [CI] = 15.9–33.3%) and 86.2% (95% CI = 84.1–88.6%), respectively.
Positive_regulation (increase) of IgM
8) Confidence 0.43 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Abstract Doc Link PMC2911186 Disease Relevance 0.50 Pain Relevance 0
An increase in the titer of antibodies by complement fixation, neutralization and ELISA (IgM) was detected.
Positive_regulation (increase) of IgM
9) Confidence 0.39 Published 1993 Journal Rev. Inst. Med. Trop. Sao Paulo Section Abstract Doc Link 7997756 Disease Relevance 1.07 Pain Relevance 0.08
In the present study, CII immunization remarkably increased collagen II antibody, IgG and IgM levels in mice serum, while EA at ST36 significantly reduced these levels in comparison with the control group or the NR group.
Positive_regulation (increased) of IgM in CII associated with immunization and acupuncture
10) Confidence 0.37 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1810363 Disease Relevance 1.96 Pain Relevance 0.91
The anti-bacterial IgM induced was specific to the commensal microflora of the host and did not bind to Salmonella, which these mice have never been exposed to (Figure S7).
Positive_regulation (induced) of IgM
11) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2715133 Disease Relevance 0 Pain Relevance 0
Gluten sensitization plus indomethacin treatment, however, resulted in induction of strong specific IgM responses directed against 40–80% of culturable bacteria.
Positive_regulation (induction) of IgM
12) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2715133 Disease Relevance 0 Pain Relevance 0
12) of all IgM positive vaccinees the IgM and IgG titres descended simultaneously, as in vaccinee no. 3.
Positive_regulation (vaccinees) of IgM
13) Confidence 0.32 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2982812 Disease Relevance 0 Pain Relevance 0
When co-injected with the reporter antigen TNP-Ficoll (trinitrophenyl Ficoll), 0.50 mg diclofenac caused significant increases in PLN weight, PLN cellularity, and induced IgM and IgG(1) anti-TNP antibody forming cells (AFCs) in the PLN.
Positive_regulation (induced) of IgM associated with diclofenac
14) Confidence 0.32 Published 2002 Journal Toxicol. Lett. Section Abstract Doc Link 11992736 Disease Relevance 0.37 Pain Relevance 0.55
Streptozotocin (1.00 mg) caused significant increases in PLN cellularity, IgM AFCs, and selectively induced IgG(2a) and IgG(2b) AFCs against TNP-OVA.
Positive_regulation (increases) of IgM
15) Confidence 0.32 Published 2002 Journal Toxicol. Lett. Section Abstract Doc Link 11992736 Disease Relevance 0.10 Pain Relevance 0.40
Furthermore, the anti-JEV antibody prevalence in the northern German population was determined by analyzing a panel of healthy German blood donors with the anti-JEV IIFT. 2% of the sera showed a positive result in the anti-JEV IgM IIFT and 4.1% in the anti-JEV IgG IIFT.


Positive_regulation (result) of IgM IIFT in blood
16) Confidence 0.30 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2982812 Disease Relevance 0.23 Pain Relevance 0
Significantly enhanced IgM and IgG1 constant region message was detected by qPCR in synovia with lymphoid aggregates (Figure 5a,b).
Positive_regulation (enhanced) of IgM
17) Confidence 0.28 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.18 Pain Relevance 0.09
A small but significant reduction in circulating RF-IgM, anti-CCP IgG, and total IgM, but not total IgG, was observed (Figure 6a).
Positive_regulation (circulating) of IgM
18) Confidence 0.28 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.06 Pain Relevance 0
A small but significant reduction in circulating RF-IgM, anti-CCP IgG, and total IgM, but not total IgG, was observed (Figure 6a).
Positive_regulation (circulating) of IgM
19) Confidence 0.28 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.06 Pain Relevance 0
Colorimetric values were converted to nanograms/milliliter, according to the standard curves generated for IgG, IgM and IgA.
Positive_regulation (generated) of IgM
20) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886834 Disease Relevance 0.24 Pain Relevance 0.14

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