INT37954

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Context Info
Confidence 0.41
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.62
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Dcn) aging (Dcn) extracellular region (Dcn)
proteinaceous extracellular matrix (Dcn)
Anatomy Link Frequency
neurons 1
DCN 1
Dcn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 2 98.20 Very High Very High Very High
lidocaine 18 92.16 High High
Snapping jaw 3 91.88 High High
local anesthetic 2 91.08 High High
Dorsal column 4 87.32 High High
medulla 9 86.76 High High
imagery 15 83.84 Quite High
Pain 1 10.00 Low Low
Deafferentation 1 6.04 Low Low
Calcium channel 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 3 91.88 High High
Tinnitus 96 77.68 Quite High
Deafness 15 51.52 Quite High
Anxiety Disorder 9 5.00 Very Low Very Low Very Low
Hyperacusis 3 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An immunohistochemical study showed that staining for decorin was weak and homogeneously distributed in the discs from birth to 2 weeks.
Negative_regulation (distributed) of decorin
1) Confidence 0.41 Published 2002 Journal Arch. Oral Biol. Section Abstract Doc Link 12102764 Disease Relevance 0.17 Pain Relevance 0.22
These findings leave questions about interactions between cortical inputs, DCN inhibition, and DCN RF plasticity.
Negative_regulation (inhibition) of DCN
2) Confidence 0.38 Published 2006 Journal Brain Res. Section Abstract Doc Link 16697977 Disease Relevance 0 Pain Relevance 0.64
Like disruptions of peripheral inputs, disruptions of DCN inhibition by DCN administration of the GABAA receptor antagonist bicuculline methiodide (BMI) also cause rapid enlargements of DCN RFs when cortical inputs are intact.
Negative_regulation (inhibition) of DCN associated with antagonist
3) Confidence 0.38 Published 2006 Journal Brain Res. Section Abstract Doc Link 16697977 Disease Relevance 0 Pain Relevance 0.60
Electrical stimulation in the caudal part of the AVCN produces long-lasting inhibition of DCN units [(1973) Exp.
Negative_regulation (inhibition) of DCN in DCN
4) Confidence 0.37 Published 1987 Journal Hear. Res. Section Abstract Doc Link 3654396 Disease Relevance 0 Pain Relevance 0.19
SIGNIFICANCE: The amplitude reduction of the DCN response during movement is possibly due to decreased excitability of the DCN neurons receiving the somatosensory ascending input.


Negative_regulation (reduction) of DCN in neurons
5) Confidence 0.37 Published 2010 Journal Clin Neurophysiol Section Body Doc Link 20153686 Disease Relevance 0 Pain Relevance 0
In that electrophysiology study DCN activity was initially decreased following exposure with increases in activity observed by five days.
Negative_regulation (decreased) of DCN
6) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002264 Disease Relevance 0.45 Pain Relevance 0.07

General Comments

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