INT3796

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Context Info
Confidence 0.77
First Reported 1977
Last Reported 2010
Negated 6
Speculated 4
Reported most in Abstract
Documents 130
Total Number 134
Disease Relevance 69.61
Pain Relevance 13.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ighm)
Anatomy Link Frequency
B cells 11
plasma cells 4
T cell 4
plasma 3
blood 3
Ighm (Mus musculus)
Pain Link Frequency Relevance Heat
depression 8 99.92 Very High Very High Very High
rheumatoid arthritis 610 99.84 Very High Very High Very High
cINOD 19 99.76 Very High Very High Very High
Kappa opioid receptor 8 99.76 Very High Very High Very High
Enkephalin 22 99.54 Very High Very High Very High
Osteoarthritis 155 99.32 Very High Very High Very High
Acupuncture 57 98.84 Very High Very High Very High
opioid receptor 16 98.84 Very High Very High Very High
Morphine 29 98.56 Very High Very High Very High
methotrexate 30 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 1727 100.00 Very High Very High Very High
Neuromyelitis Optica 1290 100.00 Very High Very High Very High
Sprains And Strains 596 100.00 Very High Very High Very High
Dengue 546 100.00 Very High Very High Very High
Rickettsiaceae Infection 425 100.00 Very High Very High Very High
Hepatitis A Virus Infection 210 100.00 Very High Very High Very High
Cytomegalovirus Infection 158 100.00 Very High Very High Very High
Bacillus Anthracis Infection 40 100.00 Very High Very High Very High
Anaerobic Bacterial Infections 38 100.00 Very High Very High Very High
Depression 10 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immediate excision and grafting (BE&G6) restored anti-PGPS IgM synthesis to normal, while nonspecific B-cell functions did not change significantly.
Gene_expression (synthesis) of IgM in B-cell
1) Confidence 0.77 Published 1996 Journal J. Surg. Res. Section Abstract Doc Link 8661190 Disease Relevance 0.91 Pain Relevance 0.08
We assessed the diagnostic capacity of a commercially available rapid ICT for detection of IgM against O. tsutsugamushi and an IBT for detection of IgM against R. typhi to aid the diagnosis of acute scrub and murine typhus infection in patients in the tropical and disease-endemic environment of the Lao People's Democratic Republic (Laos).


Gene_expression (detection) of IgM associated with disease, rickettsiaceae infection and infection
2) Confidence 0.72 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2911186 Disease Relevance 1.27 Pain Relevance 0
2) What is the relative accuracy of the admission ST ICT and MT IBT for the detection of IgM compared with the gold standard O. tsutsugamushi and R. typhi admission-phase IgM IFA assays?
Gene_expression (detection) of IgM
3) Confidence 0.72 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2911186 Disease Relevance 0 Pain Relevance 0
This study has demonstrated that in a low-resource, typhus-endemic setting, the Panbio scrub typhus ICT and murine typhus Dip-S-Ticks IBT for detecting IgM have potential for diagnosing acute infections.
Gene_expression (detecting) of IgM associated with rickettsiaceae infection, infection and epidemic louse-borne typhus
4) Confidence 0.72 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2911186 Disease Relevance 0.99 Pain Relevance 0
IgM against scrub typhus (O. tsutsugamushi pooled Karp, Kato, and Gilliam antigens) and murine typhus (R. typhi Wilmington strain antigen) IgM was detected by using an IFA assay.5 Slides for the IFA assay were obtained from the Australian Rickettsial Reference Laboratory (Geelong, Victoria, Australia).
Gene_expression (detected) of IgM associated with sprains and strains and rickettsiaceae infection
5) Confidence 0.72 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2911186 Disease Relevance 0.90 Pain Relevance 0.08
PTXF administration during resuscitation in burn injury does not ameliorate the burn-induced depression in IgM synthesis and results in significant potential adverse modulation of humoral immune function.
Gene_expression (synthesis) of IgM associated with depression, burns and injury
6) Confidence 0.64 Published 1997 Journal J Burn Care Rehabil Section Abstract Doc Link 9313117 Disease Relevance 1.78 Pain Relevance 0.17
PTXF treatment was associated with an increase in IgG production, but a greater depression in IgM synthesis than burn injury alone.
Gene_expression (synthesis) of IgM associated with depression, burns and injury
7) Confidence 0.64 Published 1997 Journal J Burn Care Rehabil Section Abstract Doc Link 9313117 Disease Relevance 1.85 Pain Relevance 0.17
IgM against scrub typhus (O. tsutsugamushi pooled Karp, Kato, and Gilliam antigens) and murine typhus (R. typhi Wilmington strain antigen) IgM was detected by using an IFA assay.5 Slides for the IFA assay were obtained from the Australian Rickettsial Reference Laboratory (Geelong, Victoria, Australia).
Gene_expression (detected) of IgM associated with sprains and strains and rickettsiaceae infection
8) Confidence 0.63 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2911186 Disease Relevance 1.00 Pain Relevance 0.09
The IFA IgM titer ?
Gene_expression (titer) of IgM
9) Confidence 0.63 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2911186 Disease Relevance 0.25 Pain Relevance 0
4-fold rising IFA titer between paired serum samples or IgM IFA titer ?
Gene_expression (titer) of IgM
10) Confidence 0.63 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2911186 Disease Relevance 0.05 Pain Relevance 0
There was a significant association between ST ICT and MT IBT positivity rates and increasing IFA IgM titers (ST ICT and MT IBT Pearson's ?
Gene_expression (titers) of IgM
11) Confidence 0.63 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2911186 Disease Relevance 0 Pain Relevance 0
Other manifestations included neurologic abnormalties, myocardial conduction abnormalities, serum cryoprecipitates, elevated serum IgM levels, and elevated erythrocyte sedimentation rates.
Gene_expression (levels) of IgM in erythrocyte associated with cv unclassified under development
12) Confidence 0.59 Published 1977 Journal Ann. Intern. Med. Section Abstract Doc Link 869348 Disease Relevance 1.37 Pain Relevance 0.34
Ultralow concentrations of proenkephalin and [met5]-enkephalin differentially affect IgM and IgG production by B cells.
Gene_expression (production) of IgM in B cells associated with enkephalin
13) Confidence 0.56 Published 1997 Journal J. Neuroimmunol. Section Title Doc Link 9058757 Disease Relevance 0 Pain Relevance 0.68
Resting mouse splenic B cells were activated with lipopolysaccharide/dextran sulfate (LPS/DxS) to measure both B cell proliferation and IgM/IgG isotype production when increasing concentrations of [Met5]-enkephalin (MENK) and proenkephalin (PENK) (10-16 to 10(-8) M) were added at increasing times after B cell activation (0, 3, 6, or 24 h).
Gene_expression (production) of IgM in B cells associated with enkephalin
14) Confidence 0.56 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058757 Disease Relevance 0 Pain Relevance 0.41
Results show that proliferation was not affected by either peptide, but that IgM, IgG3 and IgG2a production were inhibited in a concentration- and time-dependent manner by MENK.
Gene_expression (production) of IgM associated with enkephalin
15) Confidence 0.56 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058757 Disease Relevance 0 Pain Relevance 0.45
Subclass determination showed that the clones produced IgG1, IgG2a, IgG3, and IgM types of antibody.
Gene_expression (produced) of IgM
16) Confidence 0.54 Published 2002 Journal Hybrid. Hybridomics Section Abstract Doc Link 12165146 Disease Relevance 0.07 Pain Relevance 0.29
Treatment of lipopolysaccharide-stimulated lymphocytes with orphan opioid receptor antisense oligonucleotides suppressed polyclonal IgG and IgM production by 50%.
Gene_expression (production) of IgM in lymphocytes associated with opioid receptor
17) Confidence 0.53 Published 1995 Journal J. Neuroimmunol. Section Abstract Doc Link 7797625 Disease Relevance 0 Pain Relevance 0.35
An increase in the titer of antibodies by complement fixation, neutralization and ELISA (IgM) was detected.
Gene_expression (detected) of IgM
18) Confidence 0.50 Published 1993 Journal Rev. Inst. Med. Trop. Sao Paulo Section Abstract Doc Link 7997756 Disease Relevance 1.04 Pain Relevance 0.08
The Panbio Japanese Encephalitis - Dengue IgM Combo ELISA (Panbio Diagnostics, Brisbane, Australia) is based on the IgM capture format with insect cell expressed and immunopurified JEV and dengue 1–4 antigens.
Gene_expression (expressed) of IgM associated with dengue and viral meningitis
19) Confidence 0.50 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2982812 Disease Relevance 0.84 Pain Relevance 0
Compared to wild-type (WT) mice, KOR-/- animals produced significant higher levels of antigen-specific total Ig, IgM, IgG1 and IgG2a antibodies.
Gene_expression (produced) of IgM associated with kappa opioid receptor
20) Confidence 0.50 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12507774 Disease Relevance 0.24 Pain Relevance 0.57

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