INT37970

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Context Info
Confidence 0.37
First Reported 1987
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.72
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscle 1
Rbm14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 1 99.98 Very High Very High Very High
agonist 2 98.36 Very High Very High Very High
Morphine 5 89.08 High High
Nucleus accumbens 2 87.84 High High
Pain 1 85.96 High High
nMDA receptor 3 85.56 High High
addiction 2 84.48 Quite High
anesthesia 1 83.12 Quite High
cINOD 1 81.36 Quite High
depression 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Stress 3 90.88 High High
Injury 1 89.28 High High
Morphine Dependence 1 84.48 Quite High
INFLAMMATION 1 79.92 Quite High
Adhesions 2 77.36 Quite High
Depression 1 75.00 Quite High
Opiate Addiction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is suggested that depressed fibrinolysis is a result of depletion of fibrinolytic elements, plasminogen activator in particular.
Negative_regulation (depletion) of activator
1) Confidence 0.37 Published 1987 Journal Kardiologiia Section Abstract Doc Link 3656929 Disease Relevance 0.33 Pain Relevance 0.12
In control slices, Mg(2+) and phorbol 12,13-diacetate (PDAc), a protein kinase C activator, strongly inhibited and increased, respectively, NMDA EPSC amplitudes.
Negative_regulation (inhibited) of activator associated with kinase c
2) Confidence 0.19 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10516325 Disease Relevance 0.08 Pain Relevance 0.62
The aim of this study was to elucidate the effects of milrinone, a PDE III inhibitor, on d-tubocurarine (dTc)-induced muscle relaxation in vitro and then to compare its effects with those of other activators of the adenylate cyclase (AC) system (aminophylline, a non-selective PDE inhibitor; forskolin, a direct AC activator; and isoproterenol, a beta-adrenoceptor agonist).
Negative_regulation (inhibitor) of activator in muscle associated with agonist
3) Confidence 0.02 Published 1999 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 10634314 Disease Relevance 0 Pain Relevance 0.13
The most pronounced change was a decrease in the level of plasminogen activator inhibitor activity.
Negative_regulation (decrease) of activator
4) Confidence 0.01 Published 1994 Journal J. Surg. Res. Section Abstract Doc Link 8152224 Disease Relevance 0.31 Pain Relevance 0.08

General Comments

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