INT37976

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Context Info
Confidence 0.47
First Reported 1987
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.27
Pain Relevance 5.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Ripk2) kinase activity (Ripk2) cytoplasm (Ripk2)
Anatomy Link Frequency
brain 2
IPN 1
Ripk2 (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 37 100.00 Very High Very High Very High
antagonist 11 99.96 Very High Very High Very High
Opioid 6 99.32 Very High Very High Very High
analgesia 4 98.86 Very High Very High Very High
agonist 10 98.36 Very High Very High Very High
IPN 9 98.12 Very High Very High Very High
Endogenous opioid 3 97.20 Very High Very High Very High
antidepressant 1 88.28 High High
Analgesic 1 87.16 High High
Enkephalin 10 84.80 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 1 92.52 High High
Hyperalgesia 2 90.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In both rat and mouse, 125I-Bolton Hunter CCK binding in the region of the interpeduncular nucleus (IPN) was inhibited by L-365,031 indicating that these receptors resemble CCK receptors found in peripheral tissues.
CCK Binding (binding) of in IPN associated with ipn and cholecystokinin
1) Confidence 0.47 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3658220 Disease Relevance 0 Pain Relevance 0.72
A comparison of cholecystokinin (CCK) receptor binding to sections of rat, mouse and guinea pig brain has been performed using 125I-Bolton Hunter CCK and the selective peripheral CCK receptor antagonist L-365,031.
CCK Binding (binding) of in brain associated with antagonist and cholecystokinin
2) Confidence 0.47 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3658220 Disease Relevance 0 Pain Relevance 0.59
The present reports shows that in different species, regional variations in brain CCK receptor binding occur not only in the case of classical 'brain' receptors, but also for the more discretely localised 'peripheral' type CCK receptors.
CCK Binding (occur) of in brain associated with cholecystokinin
3) Confidence 0.36 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3658220 Disease Relevance 0 Pain Relevance 0.72
Taken together, these findings suggest that the potentiating effects of delta agonists on mu-mediated analgesia are due to an increase in the release of endogenous CCK interacting with CCK-A and CCK-B receptors and resulting in positive and negative regulation of the endogenous opioid system.
CCK Binding (interacting) of associated with endogenous opioid, agonist and analgesia
4) Confidence 0.36 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7996417 Disease Relevance 0.09 Pain Relevance 0.84
Taken together, these findings suggest that the potentiating effects of delta agonists on mu-mediated analgesia are due to an increase in the release of endogenous CCK interacting with CCK-A and CCK-B receptors and resulting in positive and negative regulation of the endogenous opioid system.
CCK Binding (interacting) of associated with endogenous opioid, agonist and analgesia
5) Confidence 0.36 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7996417 Disease Relevance 0.09 Pain Relevance 0.84
In this article, we review the experimental pharmacology of the association of CCK2 antagonists and opioids (exogenous and endogenous), emphasizing the clinical interest of such an association.
CCK2 Binding (association) of associated with antagonist and opioid
6) Confidence 0.09 Published 2003 Journal Drugs Today Section Abstract Doc Link 14702135 Disease Relevance 0.09 Pain Relevance 1.29

General Comments

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