INT37976

Context Info Confidence 0.47 First Reported 1987 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 6 Total Number 6 Disease Relevance 0.27 Pain Relevance 5.01

intracellular (Ripk2) kinase activity (Ripk2) cytoplasm (Ripk2)

Anatomy Link Frequency brain 2 IPN 1 Ripk2 (Mus musculus)

Pain Link Frequency Relevance Heat Cholecystokinin 37 100.00 antagonist 11 99.96 Opioid 6 99.32 analgesia 4 98.86 agonist 10 98.36 IPN 9 98.12 Endogenous opioid 3 97.20 antidepressant 1 88.28 Analgesic 1 87.16 Enkephalin 10 84.80

Disease Link Frequency Relevance Heat Targeted Disruption 1 92.52 Hyperalgesia 2 90.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In both rat and mouse, 125I-Bolton Hunter CCK binding in the region of the interpeduncular nucleus (IPN) was inhibited by L-365,031 indicating that these receptors resemble CCK receptors found in peripheral tissues.

CCK Binding (binding) of in IPN associated with ipn and cholecystokinin

1) Confidence 0.47 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3658220 Disease Relevance 0 Pain Relevance 0.72

A comparison of cholecystokinin (CCK) receptor binding to sections of rat, mouse and guinea pig brain has been performed using 125I-Bolton Hunter CCK and the selective peripheral CCK receptor antagonist L-365,031.

CCK Binding (binding) of in brain associated with antagonist and cholecystokinin

2) Confidence 0.47 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3658220 Disease Relevance 0 Pain Relevance 0.59

The present reports shows that in different species, regional variations in brain CCK receptor binding occur not only in the case of classical 'brain' receptors, but also for the more discretely localised 'peripheral' type CCK receptors.

CCK Binding (occur) of in brain associated with cholecystokinin

3) Confidence 0.36 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3658220 Disease Relevance 0 Pain Relevance 0.72

Taken together, these findings suggest that the potentiating effects of delta agonists on mu-mediated analgesia are due to an increase in the release of endogenous CCK interacting with CCK-A and CCK-B receptors and resulting in positive and negative regulation of the endogenous opioid system.

CCK Binding (interacting) of associated with endogenous opioid, agonist and analgesia

4) Confidence 0.36 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7996417 Disease Relevance 0.09 Pain Relevance 0.84

Taken together, these findings suggest that the potentiating effects of delta agonists on mu-mediated analgesia are due to an increase in the release of endogenous CCK interacting with CCK-A and CCK-B receptors and resulting in positive and negative regulation of the endogenous opioid system.

CCK Binding (interacting) of associated with endogenous opioid, agonist and analgesia

5) Confidence 0.36 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7996417 Disease Relevance 0.09 Pain Relevance 0.84

In this article, we review the experimental pharmacology of the association of CCK2 antagonists and opioids (exogenous and endogenous), emphasizing the clinical interest of such an association.

CCK2 Binding (association) of associated with antagonist and opioid

6) Confidence 0.09 Published 2003 Journal Drugs Today Section Abstract Doc Link 14702135 Disease Relevance 0.09 Pain Relevance 1.29

General Comments

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