INT37977

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Context Info
Confidence 0.42
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.92
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Ripk2) kinase activity (Ripk2) cytoplasm (Ripk2)
Anatomy Link Frequency
CER 1
brain 1
Ripk2 (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 13 100.00 Very High Very High Very High
Cancer pain 2 99.56 Very High Very High Very High
Inflammation 1 99.24 Very High Very High Very High
antagonist 6 98.28 Very High Very High Very High
Analgesic 3 92.96 High High
IPN 3 86.80 High High
Pain 7 85.72 High High
Morphine 1 82.60 Quite High
narcan 4 82.40 Quite High
Enkephalin 2 76.08 Quite High
Disease Link Frequency Relevance Heat
Cancer Pain 2 99.56 Very High Very High Very High
INFLAMMATION 1 99.24 Very High Very High Very High
Cancer 2 87.28 High High
Pain 4 85.72 High High
Nociception 2 70.16 Quite High
Pancreatic Cancer 2 52.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that Z-360 inhibits inflammatory and cancer pain probably through the blockade of CCK(1) receptors.
Negative_regulation (blockade) of CCK associated with cancer pain and inflammation
1) Confidence 0.42 Published 2010 Journal Biol. Pharm. Bull. Section Abstract Doc Link 20118547 Disease Relevance 0.92 Pain Relevance 0.93
A comparison of cholecystokinin (CCK) receptor binding to sections of rat, mouse and guinea pig brain has been performed using 125I-Bolton Hunter CCK and the selective peripheral CCK receptor antagonist L-365,031.
Negative_regulation (using) of CCK in brain associated with antagonist and cholecystokinin
2) Confidence 0.41 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3658220 Disease Relevance 0 Pain Relevance 0.66
Subcutaneous (SC) injections of ceruletide (caerulein diethylammonium hydrate, CER) and the octapeptide of cholecystokinin (CCK-8) reduced the intake of liquid food in male NMRI mice starved for 18 h.
Negative_regulation (reduced) of CCK in CER associated with cholecystokinin
3) Confidence 0.41 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6328330 Disease Relevance 0 Pain Relevance 0.44

General Comments

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