INT3798

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Context Info
Confidence 0.26
First Reported 1977
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.18
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lysosome (GNS)
Anatomy Link Frequency
knee 1
GNS (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 126 100.00 Very High Very High Very High
Pain score 12 99.38 Very High Very High Very High
Osteoarthritis 97 98.84 Very High Very High Very High
anesthesia 1 97.40 Very High Very High Very High
Central nervous system 1 91.44 High High
cINOD 25 86.40 High High
tolerance 4 80.56 Quite High
aspirin 2 75.20 Quite High
Analgesic 1 72.48 Quite High
Paracetamol 33 69.84 Quite High
Disease Link Frequency Relevance Heat
Pain 139 100.00 Very High Very High Very High
Mucopolysaccharidoses 9 99.46 Very High Very High Very High
Lysosome Storage Disease 3 99.16 Very High Very High Very High
Osteoarthritis 102 98.84 Very High Very High Very High
Disease 42 89.44 High High
Gangliosidoses 1 87.24 High High
Obesity 3 85.52 High High
Intellectual Impairment 1 83.44 Quite High
INFLAMMATION 30 80.96 Quite High
Hypersensitivity 5 50.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mucopolysaccharidosis type IIID (MPS IIID) is characterized by deficiency in lysosomal N-acetylglucosamine 6-sulfatase activity and the accumulation and excretion of heparan sulfates and N-acetylglucosamine 6-sulfate.
Negative_regulation (deficiency) of N-acetylglucosamine 6-sulfatase associated with mucopolysaccharidoses and lysosome storage disease
1) Confidence 0.26 Published 2001 Journal Mol. Genet. Metab. Section Abstract Doc Link 11243730 Disease Relevance 1.03 Pain Relevance 0.14
Another study sought to determine the effectiveness of glucosamine in the reduction of pain in OA of the knee.
Spec (determine) Negative_regulation (effectiveness) of glucosamine in knee associated with pain and osteoarthritis
2) Confidence 0.20 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686334 Disease Relevance 0.93 Pain Relevance 0.85
The in vitro inhibition of the glucosamine synthetase activity of rat gastric mucosal homogenates by sodium salicylate and phenylbutazone has been previously reported and has been adduced as a possible mechanism for the ulcerogenic effect of these drugs.
Negative_regulation (inhibition) of glucosamine synthetase
3) Confidence 0.13 Published 1977 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 869640 Disease Relevance 0 Pain Relevance 0.16
For WOMAC pain scores the overall benefit was a 60% reduction for glucosamine and 62% for reparagen.
Negative_regulation (reduction) of glucosamine associated with pain score
4) Confidence 0.00 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC2131759 Disease Relevance 0.56 Pain Relevance 0.42
At the conclusion of the study there was a 49% reduction in VAS pain in the glucosamine group and a 45% reduction in the reparagen group.
Negative_regulation (reduction) of glucosamine associated with pain
5) Confidence 0.00 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC2131759 Disease Relevance 0.66 Pain Relevance 0.64

General Comments

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