INT38008

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Context Info
Confidence 0.44
First Reported 1987
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 6.64
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (NAGLU) lysosome (NAGLU)
Anatomy Link Frequency
spinal 4
blood 2
NAGLU (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 97.80 Very High Very High Very High
Buprenorphine 1 97.44 Very High Very High Very High
alcohol 6 97.00 Very High Very High Very High
methadone 1 94.12 High High
opiate 3 92.64 High High
spinal inflammation 10 82.48 Quite High
cINOD 4 77.36 Quite High
Analgesic 11 66.20 Quite High
fibrosis 2 5.00 Very Low Very Low Very Low
Neuronal nitric oxide synthase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 8 99.92 Very High Very High Very High
Proteinuria 18 99.60 Very High Very High Very High
Disorders Of Creatine Metabolism 12 96.44 Very High Very High Very High
Diabetes Mellitus 4 96.08 Very High Very High Very High
Cyst 4 93.28 High High
Focal Segmental Glomerulosclerosis 2 92.96 High High
Renal Disease 34 91.92 High High
Albuminuria 6 88.24 High High
Disorder Of Lipid Metabolism 6 85.92 High High
Congenital Anomalies 7 85.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) was elevated in four patients; two had other biochemical evidence of renal damage while the other two patients appeared normal, although they had both received spinal irradiation in the past.
Positive_regulation (elevated) of Gene_expression (excretion) of NAG in spinal
1) Confidence 0.44 Published 1987 Journal Br. J. Rheumatol. Section Abstract Doc Link 3664158 Disease Relevance 0.95 Pain Relevance 0.54
The urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) was elevated in four patients; two had other biochemical evidence of renal damage while the other two patients appeared normal, although they had both received spinal irradiation in the past.
Positive_regulation (elevated) of Gene_expression (excretion) of N-acetyl-beta-D-glucosaminidase in spinal
2) Confidence 0.44 Published 1987 Journal Br. J. Rheumatol. Section Abstract Doc Link 3664158 Disease Relevance 0.95 Pain Relevance 0.54
NAG and RBP models were adjusted for age, sex, BMI, systolic blood pressure, current/former worker status, alcohol ingestion, and diabetes. 41 ?
Positive_regulation (adjusted) of Gene_expression (models) of NAG in blood associated with diabetes mellitus and alcohol
3) Confidence 0.25 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1253707 Disease Relevance 0.83 Pain Relevance 0.05
Transfer of L-alpha-acetylmethadol (LAAM) and L-alpha-acetyl-N-normethadol (norLAAM) by the perfused human placental lobule.
Positive_regulation (Transfer) of Gene_expression (Transfer) of L-alpha-acetyl-N-normethadol
4) Confidence 0.10 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 12676878 Disease Relevance 0 Pain Relevance 0.48
CHN2, P < 0.05) as well as a further increase in total proteinuria</span</sp<span style="background-color:#FFFF00">an>> and SCr.
Positive_regulation (increase) of Gene_expression (excretion) of NAG associated with proteinuria
5) Confidence 0.05 Published 1995 Journal Kidney Int. Section Abstract Doc Link 8544416 Disease Relevance 2.00 Pain Relevance 0.19
Five patients (CHN2) with a S beta 2m > or = 5 mg/liter had a markedly increased excretion of all LMWP, albumin and NAG (CHN1 vs.
Positive_regulation (increased) of Gene_expression (excretion) of NAG
6) Confidence 0.05 Published 1995 Journal Kidney Int. Section Abstract Doc Link 8544416 Disease Relevance 1.90 Pain Relevance 0.19

General Comments

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