INT38013

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Context Info
Confidence 0.73
First Reported 1987
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 6.03
Pain Relevance 3.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Casr) plasma membrane (Casr) signal transducer activity (Casr)
Anatomy Link Frequency
CAR 18
livers 6
knee joint 1
intestinal epithelium 1
epithelium 1
Casr (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 12 99.44 Very High Very High Very High
Bile 299 99.08 Very High Very High Very High
anesthesia 104 98.96 Very High Very High Very High
Analgesic 5 94.56 High High
fibrosis 22 92.92 High High
Inflammation 102 90.20 High High
withdrawal 3 80.00 Quite High
agonist 29 76.80 Quite High
Central nervous system 2 75.00 Quite High
member 8 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 10 99.90 Very High Very High Very High
Targeted Disruption 101 98.32 Very High Very High Very High
Hypercalcemia 11 97.92 Very High Very High Very High
Hyperplasia 19 95.24 Very High Very High Very High
Fibrosis 16 92.92 High High
Interstitial Lung Diseases 143 92.40 High High
Toxicity 18 92.32 High High
Nicotine Addiction 139 91.96 High High
Repression 20 90.96 High High
INFLAMMATION 87 90.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adenoviral expression of both PBP and EGFP-CAR restored phenobarbital-mediated nuclear translocation of exogenously expressed CAR in PBP null livers in vivo and in PBP null primary hepatocytes in vitro.
Gene_expression (expressed) of CAR in livers
1) Confidence 0.73 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16828057 Disease Relevance 0.07 Pain Relevance 0.15
Interestingly, transgenic mice expressing DN1 were resistant to the acetaminophen-induced hepatotoxicity and expression of a series of the known CAR target genes was specifically repressed in these transgenic mice.
Gene_expression (expression) of CAR in CAR associated with targeted disruption, paracetamol and hepatotoxicity
2) Confidence 0.73 Published 2005 Journal Mol. Endocrinol. Section Abstract Doc Link 15764585 Disease Relevance 0.48 Pain Relevance 0.27
Adenoviral expression of both PBP and EGFP-CAR restored phenobarbital-mediated nuclear translocation of exogenously expressed CAR in PBP null livers in vivo and in PBP null primary hepatocytes in vitro.
Gene_expression (expression) of EGFP-CAR in livers
3) Confidence 0.64 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16828057 Disease Relevance 0.06 Pain Relevance 0.14
No significant differences in percent change for CAR were found between the TENS and the focal knee joint cooling group.
Gene_expression (found) of CAR in knee joint
4) Confidence 0.64 Published 2009 Journal Med Sci Sports Exerc Section Body Doc Link 19461552 Disease Relevance 0 Pain Relevance 0
Adenoviral expression of both PBP and EGFP-CAR restored phenobarbital-mediated nuclear translocation of exogenously expressed CAR in PBP null livers in vivo and in PBP null primary hepatocytes in vitro.
Gene_expression (expression) of EGFP-CAR in livers
5) Confidence 0.56 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16828057 Disease Relevance 0.06 Pain Relevance 0.14
Our results point to a constitutively higher expression of CAR in the absence of the intestinal microbiota in GF mice, likely because of the elevated levels of the CAR activators bilirubin, bile acids and steroid hormones, the relative contributions of these are so far unknown.
Gene_expression (expression) of CAR in CAR associated with bile
6) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0.23
Currently, we can only speculate on the signals leading to the higher expression of CAR in the absence of an intestinal microbiota.
Gene_expression (expression) of CAR in CAR
7) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0.06 Pain Relevance 0.14
In line with the higher expression levels of CAR in GF mice, we observed that GF animals had a significantly shorter time of anesthesia as scored by the time between loosing and regaining the righting reflex after barbiturate injection compared to SPF animals (53 vs. 81 min, Figure 4, p<0.001, Student's t-test).
Gene_expression (expression) of CAR in CAR associated with anesthesia
8) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0.13 Pain Relevance 0.27
In addition, the CAR-regulated gene POR, coding for the P450 oxidoreductase, the unique electron donor for all type II cytochrome P450 enzymes, was more highly expressed in the GF animals compared to SPF.
Gene_expression (expressed) of CAR-regulated in CAR
9) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0.07 Pain Relevance 0.14
We have previously shown that CAR is also expressed at higher levels in GF colonic epithelium, when compared to SPF [16].
Gene_expression (expressed) of CAR in epithelium
10) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0.12 Pain Relevance 0.10
Our strategy produced differentiated cell cultures that expressed intermediate markers of endoderm and parathyroid development (CXCR4, EYA1, Six1, and Pax1), as well as markers of committed parathyroid precursors or developed parathyroid glands (glial cell missing-2 [Gcm2], CCL21, calcium sensing receptor [CaSR], and parathyroid hormone [PTH]).
Gene_expression (expressed) of calcium sensing receptor in endoderm
11) Confidence 0.49 Published 2009 Journal Stem Cells Dev. Section Abstract Doc Link 19025488 Disease Relevance 0.06 Pain Relevance 0.13
However, CAR was not altered and anti-MES were not pronounced in rats.
Neg (not) Gene_expression (pronounced) of CAR in CAR
12) Confidence 0.48 Published 1987 Journal Indian J. Physiol. Pharmacol. Section Abstract Doc Link 3666881 Disease Relevance 0.09 Pain Relevance 0.13
CAR was more highly expressed in the livers of GF compared to SPF mice, and several CAR-regulated genes were differentially expressed in the same direction.
Gene_expression (expressed) of CAR-regulated in livers
13) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0.13 Pain Relevance 0.10
CAR was more highly expressed in the livers of GF compared to SPF mice, and several CAR-regulated genes were differentially expressed in the same direction.
Gene_expression (expressed) of CAR in livers
14) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0.14 Pain Relevance 0.10
CAR was 1.6-fold lower expressed in the SPF compared to GF mice, and several CAR-regulated genes were differentially expressed in the same direction.
Gene_expression (ly expres) of CAR-regulated in CAR
15) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0
The PAR bZip genes also control the circadian expression rhythm of CAR [25].
Gene_expression (expression) of CAR in CAR
16) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0.05 Pain Relevance 0
Our results point to a constitutively higher expression of CAR in the absence of the intestinal microbiota in GF mice, likely because of the elevated levels of the CAR activators bilirubin, bile acids and steroid hormones, the relative contributions of these are so far unknown.
Gene_expression (levels) of CAR in CAR associated with bile
17) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0.25
CAR was 1.6-fold lower expressed in the SPF compared to GF mice, and several CAR-regulated genes were differentially expressed in the same direction.
Gene_expression (expressed) of CAR in CAR
18) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0
CAR was 1.6-fold lower expressed in the SPF compared to GF mice, and several CAR-regulated genes were differentially expressed in the same direction.
Gene_expression (expressed) of CAR in CAR
19) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0
CAR was more highly expressed in the livers of GF compared to SPF mice, and several CAR-regulated genes were differentially expressed in the same direction.
Gene_expression (expressed) of CAR in livers
20) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0.14 Pain Relevance 0.10

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