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Context Info
Confidence 0.31
First Reported 1987
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 1.14
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Casr) plasma membrane (Casr) signal transducer activity (Casr)
Anatomy Link Frequency
neurons 1
nerve 1
Casr (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 1 99.72 Very High Very High Very High
Osteoarthritis 1 99.08 Very High Very High Very High
transcutaneous nerve stimulation 2 98.98 Very High Very High Very High
imagery 18 98.16 Very High Very High Very High
Analgesic 3 94.56 High High
Morphine 7 90.88 High High
Bile 70 90.56 High High
chemokine 10 88.60 High High
Acute pain 9 87.76 High High
nociceptor 5 87.00 High High
Disease Link Frequency Relevance Heat
Osteoarthritis 1 99.08 Very High Very High Very High
Adhesions 8 93.40 High High
Toxicity 6 92.32 High High
Pain 29 87.76 High High
Inflammatory Bowel Disease 32 85.56 High High
Hepatotoxicity 4 75.00 Quite High
Cancer 26 67.36 Quite High
Nociception 12 50.00 Quite Low
Pressure And Volume Under Development 1 41.76 Quite Low
Hyperalgesia 13 41.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably, biological network analysis shows that several of the genes modulated by the intestinal microbiota are regulated through a general xenobiotic regulator, the nuclear receptor CAR (Figure 2).
Regulation (regulated) of CAR in CAR
1) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0
The dopaminergic and opioid systems have effects on the conditioned avoidance response (CAR), although the possible interaction between these systems on this behaviour has not been studied.
Spec (possible) Regulation (effects) of CAR in CAR associated with opioid
2) Confidence 0.27 Published 2004 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 14751417 Disease Relevance 0 Pain Relevance 0.66
PURPOSE: To determine whether transcutaneous electrical nerve stimulation (TENS) and focal knee joint cooling will affect the quadriceps central activation ratio (CAR) in patients with tibiofemoral osteoarthritis.
Spec (whether) Regulation (affect) of CAR in nerve associated with transcutaneous nerve stimulation and osteoarthritis
3) Confidence 0.22 Published 2009 Journal Med Sci Sports Exerc Section Abstract Doc Link 19461552 Disease Relevance 0.10 Pain Relevance 0.22
These differential responses may account for the significant sensitivity of the CAR knockouts, but not the PXR knockouts, to an acute LCA dose.
Regulation (sensitivity) of CAR in CAR
4) Confidence 0.22 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15358766 Disease Relevance 0.23 Pain Relevance 0.18
However, CAR was not altered and anti-MES were not pronounced in rats.
Neg (not) Regulation (altered) of CAR in CAR
5) Confidence 0.19 Published 1987 Journal Indian J. Physiol. Pharmacol. Section Abstract Doc Link 3666881 Disease Relevance 0.09 Pain Relevance 0.13
The cross-reactivity of lipid homeostasis and xenobiotic metabolism pathways was recently pin-pointed to converge at the transcription factor Insig-1 being regulated via both CAR and PXR [14].
Regulation (regulated) of CAR in CAR
6) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0.12
However, a detailed study comparing the activity of all SXR SNPs toward ligand activation and the potential interactions between these SNPs and the ability of SXR to modulate the activity of CAR and other transcription factors remains to be performed.
Regulation (activity) of CAR in CAR
7) Confidence 0.10 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.17 Pain Relevance 0.07
To assay large numbers of neurons simultaneously, we used ratiometric calcium imaging which detects global changes in cytoplasmic calcium levels and assesses both direct (e.g., modulation of a putative calcium-permeable NO receptor) and indirect (e.g., release of calcium from intracellular stores and/or downstream activation of calcium-permeable ion channels) processes.
Regulation (modulation) of calcium-permeable NO receptor in neurons associated with imagery
8) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764051 Disease Relevance 0.22 Pain Relevance 0.40
The metabolic pathway was up regulated (Fig. 5), and this was reflected by the up regulation of Rdh6, Scap, and Car 12 (increased 3.7-fold) (Table 4).
Regulation (regulation) of Car
9) Confidence 0.00 Published 2010 Journal Genes Nutr Section Body Doc Link PMC2988994 Disease Relevance 0.32 Pain Relevance 0.09

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