INT38022

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Context Info
Confidence 0.17
First Reported 1987
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.78
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Slc12a7)
Anatomy Link Frequency
brain 1
Slc12a7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 2 98.20 Very High Very High Very High
tetrodotoxin 4 96.72 Very High Very High Very High
ischemia 6 93.32 High High
imagery 14 28.76 Quite Low
anesthesia 3 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 18 99.98 Very High Very High Very High
Pressure And Volume Under Development 63 96.48 Very High Very High Very High
Brain Hemorrhage 9 94.76 High High
Cv Unclassified Under Development 6 93.32 High High
Ketoacidosis 121 91.96 High High
Brain Injury 8 91.52 High High
Middle Cerebral Artery Infarction 3 88.64 High High
Hypocapnia 10 86.84 High High
Volume Depletion And Dehydration 10 84.80 Quite High
Injury 1 67.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In those studies, it was found that the blood-brain barrier (BBB) Na-K-Cl cotransporter is present in the luminal BBB membrane (19) and is stimulated by ischemic conditions (19,40,41).
Gene_expression (present) of Na-K-Cl cotransporter in brain
1) Confidence 0.17 Published 2008 Journal Diabetes Section Body Doc Link PMC2551666 Disease Relevance 1.98 Pain Relevance 0.09
Administration of amiloride (180 microM) enhanced the overflow of tritium but attenuated the associated renal vasoconstriction produced by RNS, Vt and KCl.
Gene_expression (produced) of KCl associated with increased venous pressure under development
2) Confidence 0.14 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3668868 Disease Relevance 0.55 Pain Relevance 0.17
RNS (1-4 Hz), Vt (15-90 nmol) and KCl (150-500 mumol) produced renal vasoconstriction and enhanced the tritium overflow in a frequency- and concentration-dependent manner, respectively.
Gene_expression (produced) of KCl associated with increased venous pressure under development
3) Confidence 0.13 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3668868 Disease Relevance 0.25 Pain Relevance 0.15

General Comments

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