INT38030

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Context Info
Confidence 0.67
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 5.54
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2RY1) aging (P2RY1) plasma membrane (P2RY1)
signal transducer activity (P2RY1)
Anatomy Link Frequency
platelet 6
smooth muscle 3
spinal 1
P2RY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 217 99.98 Very High Very High Very High
adenocard 60 98.84 Very High Very High Very High
Analgesic 2 98.58 Very High Very High Very High
COX-2 inhibitor 1 98.00 Very High Very High Very High
antagonist 147 97.52 Very High Very High Very High
Central nervous system 1 93.36 High High
cytokine 15 89.68 High High
depression 10 89.64 High High
opiate 2 87.04 High High
narcan 3 86.36 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 191 99.68 Very High Very High Very High
Heart Rate Under Development 65 99.08 Very High Very High Very High
Systemic Lupus Erythematosus 8 94.52 High High
Liver Disease 1 92.00 High High
Acute Coronary Syndrome 15 90.88 High High
Depression 10 89.64 High High
Targeted Disruption 46 88.60 High High
Hypoxia 18 87.16 High High
Stress 52 83.80 Quite High
Fever 2 81.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of the P2X1 and P2Y1 receptors leads to alteration in shape and initiates a weak and transient phase of platelet aggregation.
Positive_regulation (Activation) of P2Y1 in platelet
1) Confidence 0.67 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835559 Disease Relevance 0.61 Pain Relevance 0.20
These data suggest that, depending on stimulus location, activation of P2Y1 receptors produces both apamin-sensitive and apamin-resistant IJPs in murine colonic CSM.
Positive_regulation (activation) of P2Y1 in CSM
2) Confidence 0.67 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20103587 Disease Relevance 0.06 Pain Relevance 0.25
These data, in conjunction with results obtained by using the P2 receptor antagonists TNP-ATP, PPADS and MRS2179 indicate that the current response to alpha,beta-meATP is due to P2X3 receptor activation, while the ATP-induced rise in [Ca2+]i is evoked by P2Y1 and P2Y4 receptor activation.
Positive_regulation (activation) of P2Y1 associated with antagonist
3) Confidence 0.64 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12694404 Disease Relevance 0 Pain Relevance 0.22
Thus, high levels of ADP could replace thromboxane as stimulator of IP3 by activation of P2Y1 receptors.
Positive_regulation (activation) of P2Y1
4) Confidence 0.56 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.36 Pain Relevance 0.36
Our data suggest that the residual platelet activation of 2MeS-ADP after clopidogrel treatment is partly due to an inadequate antagonistic effect of clopidogrel on the P2Y12 receptor and partly due to activation of the P2Y1 receptor, which is unaffected by clopidogrel.
Positive_regulation (activation) of P2Y1 in platelet
5) Confidence 0.55 Published 2006 Journal Purinergic Signal Section Abstract Doc Link PMC2096644 Disease Relevance 0.14 Pain Relevance 0.04
Residual platelet ADP reactivity after clopidogrel treatment is dependent on activation of both the unblocked P2Y1 and the P2Y12 receptor and is correlated with protein expression of P2Y12

Two ADP receptors have been identified on human platelets: P2Y1 and P2Y12.

Positive_regulation (activation) of P2Y1 in platelet
6) Confidence 0.55 Published 2006 Journal Purinergic Signal Section Title Doc Link PMC2096644 Disease Relevance 0.16 Pain Relevance 0.03
In addition, we suggest that the analgesic effects of vibration in humans may be mediated at the spinal level by activation of P1-purinergic receptors.
Positive_regulation (activation) of P1-purinergic in spinal associated with analgesic
7) Confidence 0.47 Published 1987 Journal Neuroscience Section Abstract Doc Link 3670602 Disease Relevance 0.49 Pain Relevance 0.97
The aim of the present study was to investigate whether residual 2MeS-ADP, a stable ADP analogue, induced platelet reactivity after clopidogrel treatment due to unblocked P2Y1 or to insufficient inhibition of P2Y12 receptor activity.
Spec (whether) Positive_regulation (induced) of P2Y1 in platelet
8) Confidence 0.40 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096644 Disease Relevance 0.33 Pain Relevance 0.03
Residual 2MeS-ADP activation via the P2Y12 and P2Y1 receptors was determined by co-incubation with the selective antagonists AR-C69931 and MRS2179 in vitro.
Positive_regulation (activation) of P2Y1 associated with antagonist
9) Confidence 0.37 Published 2006 Journal Purinergic Signal Section Abstract Doc Link PMC2096644 Disease Relevance 0.18 Pain Relevance 0.05
ASA-induced COX and specific platelet ADP receptor inhibition attenuate reflex vasodilation, suggesting platelet involvement in reflex vasodilation through the release of vasodilating factors.
Positive_regulation (induced) of platelet ADP receptor in platelet associated with aspirin and increased venous pressure under development
10) Confidence 0.32 Published 2010 Journal J. Appl. Physiol. Section Abstract Doc Link 20360429 Disease Relevance 0.51 Pain Relevance 0.47
Pacaud and co-workers found that the Ca2+-mobilising effects of 2-methylthioATP increased in VSMC during culture in serum, indicating upregulation of P2Y1 receptors in the transition from contractile to synthetic phenotype [144].
Positive_regulation (upregulation) of P2Y1
11) Confidence 0.30 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.83 Pain Relevance 0.03
Mitogenic P2Y receptors are upregulated while ion channel receptors, with only contractile effects, are downregulated in the synthetic phenotype [145].
Positive_regulation (upregulated) of P2Y
12) Confidence 0.26 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.68 Pain Relevance 0.04
Upregulation of P2Y1 and P2Y2 receptors and downregulation of P2X1 receptors on smooth muscle of varicose veins is associated with a shift from contractile to synthetic and/or proliferative roles; this phenotypic change in smooth muscle leads to weakening of vein walls and may be a causal factor in the development of varicose veins [158], an interesting parallel to the receptor changes seen in response to increased shear stress (see above) [151].


Positive_regulation (Upregulation) of P2Y1 in smooth muscle associated with stress and increased venous pressure under development
13) Confidence 0.20 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.82 Pain Relevance 0.03
It is a rapid test that uses ADP to stimulate platelets in the presence of prostaglandin (PG) E1, which inhibits activation downstream of a second ADP receptor P2Y1, thus making the assay more sensitive to the activity of P2Y12.
Positive_regulation (activation) of ADP receptor P2Y1 in platelets
14) Confidence 0.15 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0 Pain Relevance 0
These data suggest that ATP stimulates P2Y(4) receptors within the gallbladder muscularis and, in turn, stimulate prostanoid production via COX-1 leading to increased excitability of GBSM.
Positive_regulation (stimulates) of P2Y in GBSM
15) Confidence 0.03 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18436624 Disease Relevance 0 Pain Relevance 0.37
The second ADP receptor required for aggregation (variously called P2Y(ADP), P2Y(AC), P2Ycyc or P2T(AC)) is coupled to the inhibition of adenylyl cyclase through Gi.
Positive_regulation (required) of ADP receptor
16) Confidence 0.02 Published 2001 Journal Nature Section Abstract Doc Link 11196645 Disease Relevance 0.37 Pain Relevance 0.08

General Comments

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