INT38032

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Context Info
Confidence 0.98
First Reported 1987
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.23
Pain Relevance 3.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SST) extracellular region (SST) cell-cell signaling (SST)
Anatomy Link Frequency
lymph 1
brain 1
neuromuscular junction 1
SST (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 22 100.00 Very High Very High Very High
Enkephalin 18 100.00 Very High Very High Very High
Chronic pancreatitis 3 93.80 High High
antagonist 1 92.32 High High
opiate 1 91.52 High High
Neuropeptide 12 91.40 High High
cva 1 90.80 High High
Potency 2 89.64 High High
Central nervous system 1 86.44 High High
metalloproteinase 1 76.08 Quite High
Disease Link Frequency Relevance Heat
Brain Tumor 2 96.18 Very High Very High Very High
Pancreatitis 3 93.80 High High
Cv General 3 Under Development 1 90.80 High High
Pancreatic Cancer 5 86.40 High High
Lymphatic System Cancer 1 85.32 High High
Cancer 8 83.88 Quite High
Carcinoma 1 82.84 Quite High
Breast Cancer 6 81.08 Quite High
Immunotherapy Of Cancer 1 75.00 Quite High
Hyperplasia 1 71.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Solely in the case of brain tumor patients, some differences could be seen, resulting in an approximately equal distribution of somatostatin-14 and somatostatin-28 in two pools of ventricular fluid and by the detection of a degradation product of somatostatin-14 in another one.
Protein_catabolism (degradation) of somatostatin-14 in brain associated with somatostatin and brain tumor
1) Confidence 0.98 Published 1987 Journal Neurosci. Res. Section Abstract Doc Link 3670743 Disease Relevance 0.67 Pain Relevance 0.56
Glucagon and somatostatin staining was graded counting the positive cells of total numer of Langherans islet cells counted. c-Jun expression (low: < 30% and high: > 30%) was related to stage, architectural and cytological grading, vascular, lymph nodal, perineural invasion.
Protein_catabolism (graded) of somatostatin in lymph associated with somatostatin
2) Confidence 0.35 Published 1999 Journal Anticancer Res. Section Abstract Doc Link 10216507 Disease Relevance 0.64 Pain Relevance 0.26
Phosphoramidon and DL-thiorphan similarly inhibited the degradation of GRP-10 (mean of 35% inhibition), somatostatin-14 (57%) and the aminopeptidase-resistant analogue, [D-Ala2][Leu5]enkephalin (75%).
Protein_catabolism (degradation) of somatostatin-14 associated with somatostatin and enkephalin
3) Confidence 0.29 Published 1993 Journal Exp. Physiol. Section Abstract Doc Link 8448012 Disease Relevance 0 Pain Relevance 1.06
The results show that an NEP-like enzyme on the surface of gastric muscle cells degrades and inactivates enkephalins, GRP-10 and somatostatin-14 and acts in a manner analogous to that of acetylcholinesterase in the neuromuscular junction of skeletal muscle.
Protein_catabolism (degrades) of somatostatin-14 in neuromuscular junction associated with somatostatin and enkephalin
4) Confidence 0.19 Published 1993 Journal Exp. Physiol. Section Abstract Doc Link 8448012 Disease Relevance 0 Pain Relevance 1.10
Both gentisic acid and ascorbic acid are present in the Re-188-HEDP and Re-188-RC-160 formulations, and have been found to also significantly reduce radiolytic degradation of the somatostatin peptide analogues, and may have general application in the stabilization of Re-188-labeled radio-pharmaceuticals.
Protein_catabolism (degradation) of somatostatin peptide associated with somatostatin
5) Confidence 0.10 Published 1997 Journal Anticancer Res. Section Abstract Doc Link 9179235 Disease Relevance 0.92 Pain Relevance 0.37

General Comments

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