INT38033

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Context Info
Confidence 0.45
First Reported 1987
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 26
Total Number 29
Disease Relevance 14.96
Pain Relevance 3.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (HGF) extracellular space (HGF) extracellular region (HGF)
cell morphogenesis (HGF)
Anatomy Link Frequency
HGF 9
fibroblasts 3
plasma 1
hepatocyte 1
platelet 1
HGF (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 15 100.00 Very High Very High Very High
cINOD 2 100.00 Very High Very High Very High
backache 4 98.92 Very High Very High Very High
cytokine 33 97.72 Very High Very High Very High
Inflammation 15 97.32 Very High Very High Very High
anesthesia 5 96.80 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 32 96.32 Very High Very High Very High
Pain 60 94.56 High High
chemokine 17 93.80 High High
pulpitis 1 93.24 High High
Disease Link Frequency Relevance Heat
Disease 107 100.00 Very High Very High Very High
Cirrhosis 71 100.00 Very High Very High Very High
Cv General 3 Under Development 4 100.00 Very High Very High Very High
Ulcers 3 100.00 Very High Very High Very High
Hiv-narrow Range Search Term 128 99.96 Very High Very High Very High
Adhesions 17 99.88 Very High Very High Very High
Obesity 105 99.84 Very High Very High Very High
Mental Disorders 39 99.64 Very High Very High Very High
Chronic Hepatitis 35 99.56 Very High Very High Very High
Myocardial Infarction 27 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tc-99m-MIBI scintigraphy in evaluating the effect of hepatocyte growth factor gene therapy for peripheral arteriosclerosis obliterans.
Regulation (effect) of hepatocyte growth factor in hepatocyte associated with arteriosclerosis obliterans
1) Confidence 0.45 Published 2009 Journal Ann Nucl Med Section Title Doc Link 19225945 Disease Relevance 0.29 Pain Relevance 0.09
This is the first report on the usefulness of Tc-99m-MIBI scintigraphy to evaluate the effectiveness of HGF gene therapy for peripheral arteriosclerosis obliterans.
Regulation (effectiveness) of HGF gene in HGF associated with arteriosclerosis obliterans
2) Confidence 0.45 Published 2009 Journal Ann Nucl Med Section Abstract Doc Link 19225945 Disease Relevance 0.33 Pain Relevance 0.08
The aim of this study was to determine the impact of HGF on markers of adhesion formation induced by TGF-beta1 in human peritoneal fibroblasts.
Spec (determine) Regulation (impact) of HGF in fibroblasts associated with adhesions
3) Confidence 0.44 Published 2010 Journal Med. Sci. Monit. Section Abstract Doc Link 20671605 Disease Relevance 0.52 Pain Relevance 0.09
[Changes in plasma concentrations of human hepatocyte growth factor before and after major intra-abdominal surgery under nitrous oxide-sevoflurane anesthesia].
Regulation ([Changes) of hepatocyte growth factor in plasma associated with anesthesia
4) Confidence 0.37 Published 1994 Journal Masui Section Title Doc Link 7815708 Disease Relevance 0.15 Pain Relevance 0.25
Together this suggests that HGF-mediated regeneration in human cirrhosis is similarly affected in canine CH, LDH, and CIRR.
Regulation (affected) of HGF in HGF associated with chronic hepatitis and cirrhosis
5) Confidence 0.36 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.44 Pain Relevance 0
The effect of NSAIDs and a COX-2 specific inhibitor on Helicobacter pylori-induced PGE2 and HGF in human gastric fibroblasts.
Regulation (effect) of HGF in fibroblasts associated with ulcers and cinod
6) Confidence 0.36 Published 2000 Journal Aliment. Pharmacol. Ther. Section Title Doc Link 10807402 Disease Relevance 0.48 Pain Relevance 0.10
Serial changes in serum VEGF and HGF in patients with acute myocardial infarction.
Regulation (changes) of HGF in HGF associated with myocardial infarction
7) Confidence 0.35 Published 2000 Journal Cardiology Section Title Doc Link 10965088 Disease Relevance 0.75 Pain Relevance 0.21
However. the precise mechanism responsible for VEGF and HGF release in patients with coronary artery disease is still unknown.
Regulation (responsible) of HGF in coronary artery associated with coronary artery disease
8) Confidence 0.33 Published 2000 Journal Heart Vessels Section Abstract Doc Link 11289497 Disease Relevance 0.88 Pain Relevance 0.23
This is the first report to show sequential changes of HGF in the serum, as well as c-Met expression in the myocardium, in a patient with AMI.
Regulation (changes) of HGF in HGF associated with myocardial infarction
9) Confidence 0.32 Published 1999 Journal Jpn. Circ. J. Section Abstract Doc Link 10598900 Disease Relevance 0.55 Pain Relevance 0.07
Protective action of hepatocyte growth factor on transforming growth factor beta-1-induced alpha-smooth muscle actin and extracellular matrix in cultured human peritoneal fibroblasts.
Regulation (action) of hepatocyte growth factor in fibroblasts
10) Confidence 0.27 Published 2010 Journal Med. Sci. Monit. Section Title Doc Link 20671605 Disease Relevance 0.45 Pain Relevance 0.09
No increase in serum HGF value was found in patients with angina pectoris or other heart diseases.
Regulation (value) of HGF in heart associated with angina and heart disease
11) Confidence 0.27 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8619866 Disease Relevance 0.81 Pain Relevance 0.25
Consequently, concentrations of HGF in gingival crevicular fluid (GCF) increase in periodontitis.
Regulation (concentrations) of HGF in HGF associated with periodontitis
12) Confidence 0.23 Published 2003 Journal Arch. Oral Biol. Section Abstract Doc Link 14596869 Disease Relevance 0.52 Pain Relevance 0.23
We investigated the time-course changes of the serum VEGF and HGF levels in angina pectoris (AP) and acute myocardial infarction (AMI).
Regulation (changes) of HGF in HGF associated with angina and myocardial infarction
13) Confidence 0.20 Published 2003 Journal Coron. Artery Dis. Section Abstract Doc Link 12826929 Disease Relevance 0.27 Pain Relevance 0.10
MSMB, CCND1, EFNA3, FKBP and ADM, HGF are similarly regulated in mouse models and in our study [35-37].
Regulation (regulated) of HGF in HGF
14) Confidence 0.17 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.68 Pain Relevance 0.04
Furthermore, lack of HGF-responsiveness was also observed by reduced expression of beta-catenin and TGF-alpha in the cHCC cell line, which is in accordance with findings in human HCC [16].
Regulation (responsiveness) of HGF in HGF associated with hepatocellular cancer
15) Confidence 0.13 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC535891 Disease Relevance 0.53 Pain Relevance 0
Interestingly, the levels of 4 growth factors were found to be significant in the patients, with up-regulation of HGF, FGF-basic and VEGF, with the exception of EGF which was almost totally suppressed (Figure 2c).
Regulation (regulation) of HGF in HGF
16) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2625438 Disease Relevance 0.18 Pain Relevance 0.38
In the latter groups changes in SF-6D domains cancelled each other out.


Regulation (changes) of SF-6D
17) Confidence 0.05 Published 2006 Journal Health Qual Life Outcomes Section Abstract Doc Link PMC1475841 Disease Relevance 0.21 Pain Relevance 0.18
The significant deterioration in social functioning and role limitations cancelled out the improvement in mental health, resulting in no change in the overall SF-6D score.
Neg (no) Regulation (change) of SF-6D associated with mental disorders
18) Confidence 0.05 Published 2006 Journal Health Qual Life Outcomes Section Body Doc Link PMC1475841 Disease Relevance 0.28 Pain Relevance 0.13
The SF-MPQ was also shown to be sufficiently sensitive to demonstrate differences due to treatment at statistical levels comparable to those obtained with the standard form.
Regulation (sensitive) of SF-MPQ
19) Confidence 0.04 Published 1987 Journal Pain Section Abstract Doc Link 3670870 Disease Relevance 0.31 Pain Relevance 0.57
The valuation task for the SF-6D used the worst possible health state ('pits') on the SF-6D as is the worst outcome, valued with the standard gamble method.
Regulation (valued) of SF-6D in pits
20) Confidence 0.03 Published 2006 Journal Health Qual Life Outcomes Section Body Doc Link PMC1475841 Disease Relevance 0.26 Pain Relevance 0.22

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