INT38036

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Context Info
Confidence 0.57
First Reported 1987
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 3.74
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Rac2) intracellular (Rac2) GTPase activity (Rac2)
cytoplasm (Rac2)
Anatomy Link Frequency
eosinophils 3
neutrophils 2
ear 1
Rac2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 140 98.62 Very High Very High Very High
antagonist 6 96.88 Very High Very High Very High
Opioid 3 96.66 Very High Very High Very High
Inflammatory response 19 88.96 High High
dexamethasone 1 85.76 High High
Kinase C 17 78.16 Quite High
narcan 2 74.56 Quite High
Inflammatory stimuli 2 52.24 Quite High
halothane 1 26.16 Quite Low
anesthesia 5 16.96 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 17 100.00 Very High Very High Very High
Otitis 1 98.62 Very High Very High Very High
Leukocytosis 6 98.20 Very High Very High Very High
Toxicity 7 97.92 Very High Very High Very High
INFLAMMATION 154 95.62 Very High Very High Very High
Pressure And Volume Under Development 8 92.08 High High
Hypersensitivity 377 91.04 High High
Asthma 417 89.04 High High
Eosinophilia 12 88.24 High High
General Immunology 56 80.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antidotal effects of antiinflammatory agents, inhibitors of bioamine syntheses, an opioid antagonist and other pharmacological agents on lethal toxicity, leukocytosis and ear inflammation, were investigated in mice subcutaneously administered or topically exposed to T-2 toxin, a trichothecene mycotoxin of Fusarium species.
Gene_expression (exposed) of T-2 toxin in ear associated with toxicity, inflammation, antagonist, leukocytosis, otitis and opioid
1) Confidence 0.57 Published 1987 Journal Toxicon Section Abstract Doc Link 3672543 Disease Relevance 0.78 Pain Relevance 0.46
There are several isoforms of the Rac GTPase, with Rac1 being the predominant isoform in macrophages and monocytic cells while Rac2 is predominantly expressed in neutrophils [44].
Gene_expression (expressed) of Rac2 in neutrophils
2) Confidence 0.27 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.05 Pain Relevance 0.07
Methods: We isolated splenic eosinophils from CD2-IL-5 transgenic mice (WT) and Rac2-deficient mice bred against the CD2-IL-5 transgenic background (Rac2 KO/IL-5 Tg) and compared their ability to release superoxide in response to phorbol myristate acetate (PMA).
Gene_expression (background) of Rac2 in eosinophils associated with targeted disruption
3) Confidence 0.21 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.82 Pain Relevance 0.12
This was similar to Rac2 KO neutrophils, which exhibit a deficiency (?
Gene_expression (neutrophils) of Rac2 in neutrophils
4) Confidence 0.21 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.73 Pain Relevance 0.15
While neutrophils express mainly Rac2, and Rac2 is the dominant protein that activates NADPH oxidase, it is not known whether Rac1 or Rac2 preferentially activates the oxidase in eosinophils.
Gene_expression (express) of Rac2 in eosinophils
5) Confidence 0.18 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.64 Pain Relevance 0.07
While neutrophils express mainly Rac2, and Rac2 is the dominant protein that activates NADPH oxidase, it is not known whether Rac1 or Rac2 preferentially activates the oxidase in eosinophils.
Gene_expression (express) of Rac2 in eosinophils
6) Confidence 0.08 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.65 Pain Relevance 0.07
Deoxynivalenol, T-2 toxin, and verrucarin A (Sigma Chemical Co., St.
Gene_expression (Deoxynivalenol) of T-2 toxin
7) Confidence 0.01 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1513335 Disease Relevance 0.07 Pain Relevance 0

General Comments

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