INT38056

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1987
Last Reported 2010
Negated 1
Speculated 6
Reported most in Body
Documents 71
Total Number 77
Disease Relevance 53.14
Pain Relevance 17.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crp)
Anatomy Link Frequency
erythrocyte 6
plasma 3
joint 3
liver 2
macrophages 1
Crp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory marker 79 100.00 Very High Very High Very High
Angina 56 100.00 Very High Very High Very High
Inflammatory mediators 30 100.00 Very High Very High Very High
addiction 5 99.90 Very High Very High Very High
aspirin 19 99.66 Very High Very High Very High
Adalimumab 342 99.52 Very High Very High Very High
Inflammation 640 99.50 Very High Very High Very High
psoriasis 40 99.30 Very High Very High Very High
Pain 190 99.10 Very High Very High Very High
spinal inflammation 125 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 799 100.00 Very High Very High Very High
Cv General 3 Under Development 66 100.00 Very High Very High Very High
Alzheimer's Dementia 17 100.00 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 6 100.00 Very High Very High Very High
Nicotine Addiction 66 99.96 Very High Very High Very High
Injury 49 99.84 Very High Very High Very High
Sepsis 172 99.48 Very High Very High Very High
Disease 588 99.46 Very High Very High Very High
Bacterial Respiratory Disease 5 99.36 Very High Very High Very High
Psoriasis 46 99.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Normalization of CRP was rapid after control of infection or within three weeks of successful revision THA.
Localization (Normalization) of CRP associated with infection
1) Confidence 0.78 Published 1987 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 3677512 Disease Relevance 0.17 Pain Relevance 0.16
OBJECTIVES: This study was designed to assess the interaction between aspirin and C-reactive protein (CRP) release in unstable angina.
Localization (release) of CRP associated with aspirin and angina
2) Confidence 0.78 Published 2001 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 11300433 Disease Relevance 0.17 Pain Relevance 0.26
OBJECTIVES: This study was designed to assess the interaction between aspirin and C-reactive protein (CRP) release in unstable angina.
Localization (release) of C-reactive protein associated with aspirin and angina
3) Confidence 0.78 Published 2001 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 11300433 Disease Relevance 0.17 Pain Relevance 0.26
Aspirin has the potential to influence CRP release, either by its anti-inflammatory activity or by reducing myocardial necrosis.
Localization (release) of CRP
4) Confidence 0.78 Published 2001 Journal J. Am. Coll. Cardiol. Section Body Doc Link 11300433 Disease Relevance 0.09 Pain Relevance 0
METHODS AND RESULTS: In 156 consecutive patients, early release kinetics of CRP and cTnT were analyzed.
Spec (analyzed) Localization (release) of CRP
5) Confidence 0.77 Published 2000 Journal Clin. Chem. Section Body Doc Link 11017937 Disease Relevance 0 Pain Relevance 0
Immunoreactivity to CRP was localized to macrophages, smooth muscle cells, and necrotic areas.
Localization (localized) of CRP in smooth muscle cells
6) Confidence 0.75 Published 2003 Journal Am. J. Cardiol. Section Abstract Doc Link 12565084 Disease Relevance 1.05 Pain Relevance 0.51
CONCLUSION: This study indicates that in patients referred to the ER with chest pain and no other indication for hospitalization, a normal level of CRP suggests safe release.
Localization (release) of CRP in chest
7) Confidence 0.74 Published 2002 Journal Clin Cardiol Section Body Doc Link 12375803 Disease Relevance 0.10 Pain Relevance 0
DISCUSSION: In ACS, it is plausible that ruptured plaques and inflamed tissue may be more prone to opsonization by monomeric CRP leading to consumption of anti-CRP.
Localization (opsonization) of CRP in plaques
8) Confidence 0.74 Published 2009 Journal Clin. Chim. Acta Section Body Doc Link 18973750 Disease Relevance 0.27 Pain Relevance 0
Clinical relevance of C-reactive protein in axial involvement of ankylosing spondylitis.
Localization (relevance) of C-reactive protein associated with spinal inflammation
9) Confidence 0.74 Published 1999 Journal J. Rheumatol. Section Title Doc Link 10229430 Disease Relevance 0.78 Pain Relevance 0.77
On multivariate analysis, with stage, PS, albumin, and gender as covariates, both smoking at start of chemotherapy and CRP elevation were independent negative prognostic factors for survival.
Localization (elevation) of CRP
10) Confidence 0.74 Published 2009 Journal J Thorac Oncol Section Body Doc Link 19155996 Disease Relevance 0.10 Pain Relevance 0
Baseline characteristics of the ELMI and UC groups (age, gender, presence of concurrent disease, diagnosis, lifestyle behaviours and IHD risk factors and changes to these factors as a result of the prior CRP) were compared using Pearson Chi-square tests for categorical factors and independent samples t-test for continuous factors.
Localization (result) of CRP associated with coronary artery disease and disease
11) Confidence 0.74 Published 2002 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC149404 Disease Relevance 0.48 Pain Relevance 0
Measurement of both ESR and CRP is helpful in differentiating septic and mechanical loosening, detecting complications, and monitoring the effects of treatment, but CRP is more informative and sensitive than ESR for these purposes.
Localization (Measurement) of CRP
12) Confidence 0.73 Published 1987 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 3677512 Disease Relevance 0.15 Pain Relevance 0.14
Patients' characteristics (including age, sex, the presence of rheumatoid factor and anti-cyclic citrullinated peptide antibodies, HLA-B27 status, axial involvement, erythrocyte sedimentation rate and C-reactive protein) are summarized in Table 1.
Localization (presence) of C-reactive protein in erythrocyte
13) Confidence 0.73 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 1.11 Pain Relevance 0.37
The risk of PMCE based on CRP cut-off (?
Localization (based) of CRP
14) Confidence 0.70 Published 2010 Journal Heart Section Body Doc Link PMC2791233 Disease Relevance 0.28 Pain Relevance 0
Immunohistochemical staining (IHCS) was performed to localize CRP in the atheroma.
Localization (localize) of CRP
15) Confidence 0.70 Published 2007 Journal Chang Gung Med J Section Body Doc Link 17939261 Disease Relevance 0 Pain Relevance 0
When clinical signs and symptoms of inflammation (fever, acute soft tissue swelling, and erythema) were not present, the concentration of CRP was normal in 91.2% of patients, whereas only 17.6% of patients had normal ESR.
Localization (concentration) of CRP
16) Confidence 0.69 Published 2004 Journal J Spinal Cord Med Section Body Doc Link 15648796 Disease Relevance 0.12 Pain Relevance 0
For Group OT, there were significant decreases in CRP at 4 weeks (-0.35 ± 0.2; 28%) and 8 weeks (-0.62 ± 0.2; 49%) compared to baseline (both p < 0.001).
Localization (decreases) of CRP
17) Confidence 0.69 Published 2009 Journal Nutr J Section Body Doc Link PMC2739863 Disease Relevance 0.34 Pain Relevance 0.04
BACKGROUND: C-reactive protein release in acute coronary syndromes may be a response to myocardial necrosis or may reflect the inflammatory process that drives atherogenesis.
Localization (release) of C-reactive protein
18) Confidence 0.68 Published 2001 Journal J. Am. Coll. Cardiol. Section Body Doc Link 11300433 Disease Relevance 0.10 Pain Relevance 0
Cytokines exert their biological effects on CRP by signaling through their receptors on hepatic cells and activating different kinases and phosphatases leading to translocation of various transcription factors on CRP gene promoter and production of CRP protein.
Localization (translocation) of CRP associated with cytokine
19) Confidence 0.68 Published 2009 Journal Adv Clin Chem Section Abstract Doc Link 19803417 Disease Relevance 0.60 Pain Relevance 0.60
Skewed variables (i.e. plasma triglycerides, insulin and hs-CRP) were log transformed for the analyses and back transformed to the original values in tables and figures.
Localization (transformed) of CRP in plasma
20) Confidence 0.68 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2987999 Disease Relevance 0.05 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox