INT38067

Context Info Confidence 0.55 First Reported 1987 Last Reported 1987 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.55 Pain Relevance 1.25

nucleus (MSC) DNA binding (MSC)

MSC (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 2 98.88 Morphine 6 96.36 Equianalgesic 1 93.64 Analgesic 2 92.52 analgesia 2 82.96 Cancer pain 1 75.00 tolerance 1 60.16 Opioid 1 50.80 Potency 1 42.80

Disease Link Frequency Relevance Heat Pain 2 98.88 Cancer 2 87.04 Cancer Pain 1 75.00 Sleep Disorders 1 66.96 Constipation 1 65.92 Vomiting 1 64.24 Reprotox - General 2 1 43.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Patients then were switched to MSC q8h and eventually to q12h, starting at doses representing the same total daily amount of morphine that was in the final IRMS dose.

Transcription (switched) of MSC associated with morphine

1) Confidence 0.55 Published 1987 Journal J Clin Pharmacol Section Abstract Doc Link 3680567 Disease Relevance 0.55 Pain Relevance 1.25

General Comments

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