INT38087

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Context Info
Confidence 0.61
First Reported 1980
Last Reported 2010
Negated 6
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 4.56
Pain Relevance 4.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adh1) mitochondrion (Adh1) oxidoreductase activity (Adh1)
intracellular (Adh1) embryo development (Adh1) cytoplasm (Adh1)
Anatomy Link Frequency
plasma 3
liver 3
blood 2
stem cell 1
heart 1
Adh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 26 100.00 Very High Very High Very High
lidocaine 8 99.84 Very High Very High Very High
halothane 2 99.80 Very High Very High Very High
anesthesia 8 99.48 Very High Very High Very High
noradrenaline 3 98.78 Very High Very High Very High
Morphine 14 97.88 Very High Very High Very High
Acupuncture 7 97.66 Very High Very High Very High
Analgesic 10 97.04 Very High Very High Very High
Clonidine 19 95.88 Very High Very High Very High
Catecholamine 2 94.92 High High
Disease Link Frequency Relevance Heat
Cancer 10 99.36 Very High Very High Very High
Stress 26 98.92 Very High Very High Very High
Hypoxia 5 97.68 Very High Very High Very High
Heart Rate Under Development 1 97.04 Very High Very High Very High
Injury 70 96.80 Very High Very High Very High
Diuresis 5 95.68 Very High Very High Very High
Stroke 9 94.84 High High
Pressure Volume 2 Under Development 3 94.84 High High
Pain 2 87.36 High High
Disease 5 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of castration on liver alcohol dehydrogenase (ADH) activity and the in vivo metabolism of ethanol were examined in the male Sprague-Dawley-derived rat.
Regulation (effects) of ADH in liver associated with alcohol
1) Confidence 0.61 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7003096 Disease Relevance 0 Pain Relevance 0.16
M-5041T at 1.5 mg/kg did not affect plasma levels of ADH.
Neg (not) Regulation (affect) of ADH in plasma
2) Confidence 0.43 Published 1996 Journal Fundam Clin Pharmacol Section Abstract Doc Link 8900500 Disease Relevance 0.66 Pain Relevance 1.14
Isoproterenol had no effect on ADH release and produced a slight reduction in arterial pressure and a large increase in heart rate.
Neg (no) Regulation (effect) of ADH in heart associated with heart rate under development
3) Confidence 0.40 Published 1981 Journal Endocrinology Section Abstract Doc Link 7215302 Disease Relevance 0.17 Pain Relevance 0.18
Both Adh1 and Aldh1a1 were down regulated (Table 2), which could reduce the elimination rate of ethanol.
Regulation (regulated) of Adh1
4) Confidence 0.36 Published 2010 Journal Genes Nutr Section Body Doc Link PMC2988994 Disease Relevance 0.69 Pain Relevance 0.20
In group I, plasma ADH values remained unchanged throughout the study.
Neg (unchanged) Regulation (unchanged) of ADH in plasma
5) Confidence 0.32 Published 1985 Journal Br J Anaesth Section Abstract Doc Link 3986069 Disease Relevance 0 Pain Relevance 0.64
Pretreatment with prazosin did not block significantly the effect of NE on blood pressure, heart rate, and ADH release.
Regulation (effect) of ADH in blood
6) Confidence 0.27 Published 1984 Journal Endocrinology Section Abstract Doc Link 6323145 Disease Relevance 0.35 Pain Relevance 0.08
ADH levels showed no significant changes.
Neg (no) Regulation (changes) of ADH
7) Confidence 0.27 Published 1987 Journal Anaesthesist Section Abstract Doc Link 3688417 Disease Relevance 0.35 Pain Relevance 0.77
Simultaneously, some studies demonstrated that the physiological factors that change liver ADH activity cause alteration in the rate of ethanol metabolism.[59–61] These evidences support the opinion that the level of ADH is a key factor controlling the metabolic rate of ethanol in vivo.
Regulation (controlling) of ADH in liver
8) Confidence 0.26 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2900062 Disease Relevance 0.52 Pain Relevance 0
Simultaneously, some studies demonstrated that the physiological factors that change liver ADH activity cause alteration in the rate of ethanol metabolism.[59–61] These evidences support the opinion that the level of ADH is a key factor controlling the metabolic rate of ethanol in vivo.
Regulation (change) of ADH in liver
9) Confidence 0.26 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2900062 Disease Relevance 0.58 Pain Relevance 0
The results suggest that OMF anesthesia itself showed no obvious effect on the plasma concentration of C, CS and ADH, but blocked the hormoral stress responses such as the increment of plasma CS level caused by trauma stimulus.
Neg (no) Regulation (effect) of ADH in plasma associated with stress, anesthesia and injury
10) Confidence 0.26 Published 1997 Journal Yao Xue Xue Bao Section Abstract Doc Link 11327028 Disease Relevance 0.47 Pain Relevance 0.17
Intracranial volume receptors: possible role on ADH homeostatic control.
Regulation (control) of ADH
11) Confidence 0.26 Published 1996 Journal J. Endocrinol. Invest. Section Title Doc Link 8884540 Disease Relevance 0.17 Pain Relevance 0.09
Pentobarbitone anaesthesia had no significant effect on the level of ADH but halothane anaesthesia elicited a rise in ADH.
Neg (no) Regulation (effect) of ADH associated with halothane
12) Confidence 0.25 Published 1980 Journal J. Endocrinol. Section Abstract Doc Link 7400713 Disease Relevance 0.44 Pain Relevance 0.09
Acute administration of narcotic analgesics to rats increases the blood levels of ACTH, GH and prolactin, and decreases levels of LH and TSH, however, there is no general consensus regarding changes in serum FSH, ADH and oxytocin as induced by narcotics in rats.
Regulation (changes) of ADH in blood associated with analgesic
13) Confidence 0.08 Published 1980 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 6110621 Disease Relevance 0 Pain Relevance 0.59
Per-operatively acupuncture plus TES in Group 1 showed a response of circulating NA and cortisol similar to that in Groups 2 and 3, whereas the responses of the circulating A, ACTH, beta E and ADH in Group 1 were more pronounced (P < 0.01).
Regulation (responses) of ADH associated with noradrenaline and acupuncture
14) Confidence 0.02 Published 1993 Journal Eur J Anaesthesiol Section Abstract Doc Link 8388332 Disease Relevance 0.06 Pain Relevance 0.49
The relationship between functional improvements in ischemic rats given a neural stem cell (NSC) transplant and the modulation of the class I major histocompatibility complex (MHC) mediated by NSC-derived neurotrophins was investigated.


Regulation (modulation) of class I in stem cell
15) Confidence 0.01 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2936305 Disease Relevance 0.09 Pain Relevance 0.21

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